Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation
– Synlett
(2015)
26,
1470
(doi: 10.1055/s-0034-1380679)
A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds
– Angewandte Chemie - International Edition
(2015)
54,
7920
(doi: 10.1002/anie.201501538)
Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride
– ACS Sustainable Chemistry & Engineering
(2015)
3,
1453
A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds
– Angewandte Chemie
(2015)
127,
8031
(doi: 10.1002/ange.201501538)
A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds.
– Angewandte Chemie International Edition
(2015)
54,
7920
(doi: 10.1002/anie.201501538)
Thiazole formation through a modified Gewald reaction.
– Beilstein journal of organic chemistry
(2015)
11,
875
(doi: 10.3762/bjoc.11.98)
A practical deca-gram scale ring expansion of (R)-(-)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1
– Organic & Biomolecular Chemistry
(2015)
13,
7633
(doi: 10.1039/c5ob00525f)
Large-Scale Synthesis of Crystalline 1,2,3,4,6,7-Hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose.
– European journal of organic chemistry
(2015)
2015,
2718
(doi: 10.1002/ejoc.201500024)
Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines
– Organic & Biomolecular Chemistry
(2015)
13,
4231
(doi: 10.1039/c5ob00245a)
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