Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.

M Baumann, IR Baxendale

Beilstein Journal of Organic Chemistry

(2015)

11

1194

(doi: 10.3762/bjoc.11.134)

Machine-Assisted Organic Synthesis

SV Ley, DE Fitzpatrick, RM Myers, C Battilocchio, RJ Ingham

Angew Chem Int Ed Engl

(2015)

54

10122

(doi: 10.1002/anie.201501618)

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors

D De Lucia, OM Lucio, B Musio, A Bender, M Listing, S Dennhardt, A Koeberle, U Garscha, R Rizzo, S Manfredini, O Werz, SV Ley

European journal of medicinal chemistry

(2015)

103

573

(doi: 10.1016/j.ejmech.2015.07.011)

Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation

A Hafner, SV Ley

Synlett

(2015)

26

1470

(doi: 10.1055/s-0034-1380679)

Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439

S-H Lau, A Galván, RR Merchant, C Battilocchio, JA Souto, MB Berry, SV Ley

Organic letters

(2015)

17

3218

(doi: 10.1021/acs.orglett.5b01307)

A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds

JS Poh, DN Tran, C Battilocchio, JM Hawkins, SV Ley

Angewandte Chemie - International Edition

(2015)

54

7920

(doi: 10.1002/anie.201501538)

Thiazole formation through a modified Gewald reaction.

CJ Mallia, L Englert, GC Walter, IR Baxendale

Beilstein J Org Chem

(2015)

11

875

(doi: 10.3762/bjoc.11.98)

Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride

C Schotten, D Plaza, S Manzini, SP Nolan, SV Ley, DL Browne, A Lapkin

ACS sustainable chemistry & engineering

(2015)

3

1453

(doi: 10.1021/acssuschemeng.5b00397)

A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds

J Poh, DN Tran, C Battilocchio, JM Hawkins, SV Ley

Angewandte Chemie

(2015)

127

8031

(doi: 10.1002/ange.201501538)

A practical deca-gram scale ring expansion of (R)-(-)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1

LDC Alves, AL Desiderá, KT de Oliveira, S Newton, SV Ley, TJ Brocksom

Org Biomol Chem

(2015)

13

7633

(doi: 10.1039/c5ob00525f)