Professor Jason Chin FMedSci FRS | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology

Publications

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.

C Dickson, AJ Fletcher, M Vaysburd, J-C Yang, DL Mallery, J Zeng, CM Johnson, SH McLaughlin, M Skehel, S Maslen, J Cruickshank, N Huguenin-Dezot, JW Chin, D Neuhaus, LC James

eLife

(2018)

7

e32660

(doi: 10.7554/elife.32660)

Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix

SG Burgess, M Mukherjee, S Sabir, N Joseph, C Gutiérrez-Caballero, MW Richards, N Huguenin-Dezot, JW Chin, EJ Kennedy, M Pfuhl, SJ Royle, F Gergely, R Bayliss

The EMBO Journal

(2018)

37

e97902

(doi: 10.15252/embj.201797902)

Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction

B Oller-Salvia, G Kym, JW Chin

Angew Chem Int Ed Engl

(2018)

57

2831

(doi: 10.1002/anie.201712370)

Detecting RNA base methylations in single cells by in situ hybridization

RT Ranasinghe, MR Challand, KA Ganzinger, BW Lewis, C Softley, WH Schmied, MH Horrocks, N Shivji, JW Chin, J Spencer, D Klenerman

Nat Commun

(2018)

9

655

(doi: 10.1038/s41467-017-02714-7)

Labeling and identifying cell-specific proteomes in the mouse brain.

TP Krogager, RJ Ernst, TS Elliott, L Calo, V Beránek, E Ciabatti, MG Spillantini, M Tripodi, MH Hastings, JW Chin

Nat Biotechnol

(2018)

36

156

(doi: 10.1038/nbt.4056)

Toward an orthogonal central dogma

CC Liu, MC Jewett, JW Chin, CA Voigt

Nat Chem Biol

(2018)

14

103

(doi: 10.1038/nchembio.2554)

Encoding optical control in LCK kinase to study its function and effect of coreceptor binding in live cells.

A Liaunardy-Jopeace, BL Murton, M Mahesh, JW Chin, JR James

Nature Structural & Molecular Biology

(2017)

24

1155

(doi: 10.1038/nsmb.3492)

Expanding and reprogramming the genetic code.

JW Chin

Nature

(2017)

550

53

(doi: 10.1038/nature24031)

Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling (vol 15, pg 6640, 2017)

WD Lambert, SL Scinto, O Dmitrenko, SJ Boyd, R Magboo, RA Mehl, JW Chin, JM Fox, S Wallace

Organic & Biomolecular Chemistry

(2017)

15

7476

(doi: 10.1039/c7ob90144e)

Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling.

WD Lambert, SL Scinto, O Dmitrenko, SJ Boyd, R Magboo, RA Mehl, JW Chin, JM Fox, S Wallace

Organic & biomolecular chemistry

(2017)

15

6640

(doi: 10.1039/c7ob01707c)