Yusuf Hamied Department of Chemistry

Professor Jason Chin FMedSci FRS

Professor of Chemistry & Chemical Biology

Publications

Total synthesis of Escherichia coli with a recoded genome.
J Fredens, K Wang, D de la Torre, LFH Funke, WE Robertson, Y Christova, T Chia, WH Schmied, DL Dunkelmann, V Beránek, C Uttamapinant, AG Llamazares, TS Elliott, JW Chin
Nature
(2019)
569
(doi: 10.1038/s41586-019-1192-5)
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid
N Huguenin-Dezot, DA Alonzo, GW Heberlig, M Mahesh, DP Nguyen, MH Dornan, CN Boddy, TM Schmeing, JW Chin
Nature
(2018)
565
(doi: 10.1038/s41586-018-0781-z)
Controlling orthogonal ribosome subunit interactions enables evolution of new function.
WH Schmied, Z Tnimov, C Uttamapinant, CD Rae, SD Fried, JW Chin
Nature
(2018)
564
(doi: 10.1038/s41586-018-0773-z)
Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice.
ES Maywood, TS Elliott, AP Patton, TP Krogager, JE Chesham, RJ Ernst, V Beránek, M Brancaccio, JW Chin, MH Hastings
Proceedings of the National Academy of Sciences
(2018)
115
(doi: 10.1073/pnas.1811438115)
Correction to "Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins".
C Uttamapinant, JD Howe, K Lang, V Beránek, L Davis, M Mahesh, NP Barry, JW Chin
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.8b10479)
An Evolved Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase/tRNA Pair Is Highly Active and Orthogonal in Mammalian Cells
V Beránek, JCW Willis, JW Chin
Biochemistry
(2018)
58
(doi: 10.1021/acs.biochem.8b00808)
A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation.
M Baumdick, M Gelléri, C Uttamapinant, V Beránek, JW Chin, PIH Bastiaens
Nature Communications
(2018)
9
(doi: 10.1038/s41467-018-06299-7)
Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release
M Mukherjee, S Sabir, L O'Regan, J Sampson, MW Richards, N Huguenin-Dezot, JR Ault, JW Chin, A Zhuravleva, AM Fry, R Bayliss
Science Signaling
(2018)
11
(doi: 10.1126/scisignal.aao2464)
Genetically Encoded Protein Phosphorylation in Mammalian Cells.
V Beránek, CD Reinkemeier, MS Zhang, AD Liang, G Kym, JW Chin
Cell Chemical Biology
(2018)
25
(doi: 10.1016/j.chembiol.2018.05.013)
Pyrophosphorylation via selective phosphoprotein derivatization
AM Marmelstein, JAM Morgan, M Penkert, DT Rogerson, JW Chin, E Krause, D Fiedler
Chemical Science
(2018)
9
(doi: 10.1039/c8sc01233d)

Research Group

Research Interest Group

Email address

chin@mrc-lmb.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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