Professor of Chemistry & Chemical Biology
Publications
Refactored genetic codes enable bidirectional genetic isolation.
– Science (New York, N.Y.)
(2022)
378,
516
(doi: 10.1126/science.add8943)
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans
– Genes & Development
(2022)
36,
210
(doi: 10.1101/gad.349223.121)
Mechanism-based traps enable protease and hydrolase substrate discovery
– Nature
(2022)
602,
701
(doi: 10.1038/s41586-022-04414-9)
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons
– Proceedings of the National Academy of Sciences
(2022)
119,
e2113845119
(doi: 10.1073/pnas.2113845119)
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites.
– Molecular cell
(2021)
81,
4891
(doi: 10.1016/j.molcel.2021.10.011)
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design.
– Nature chemistry
(2021)
13,
1110
(doi: 10.1038/s41557-021-00764-5)
Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase.
– eLife
(2021)
10,
e67075
(doi: 10.7554/elife.67075)
Sense codon reassignment enables viral resistance and encoded polymer synthesis.
– Science
(2021)
372,
1057
(doi: 10.1126/science.abg3029)
Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS.
– Nat Protoc
(2021)
16,
2345
(doi: 10.1038/s41596-020-00464-3)
Selective CRAF Inhibition Elicits Transactivation.
– Journal of the American Chemical Society
(2021)
143,
4600
(doi: 10.1021/jacs.0c11958)
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