Yusuf Hamied Department of Chemistry

Professor Jason Chin FMedSci FRS

Professor of Chemistry & Chemical Biology

Publications

Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism.
DL Dunkelmann, C Piedrafita, A Dickson, KC Liu, TS Elliott, M Fiedler, D Bellini, A Zhou, D Cervettini, JW Chin
Nature
(2024)
625
(doi: 10.1038/s41586-023-06897-6)
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly.
JF Zürcher, AA Kleefeldt, LFH Funke, J Birnbaum, J Fredens, S Grazioli, KC Liu, M Spinck, G Petris, P Murat, FBH Rehm, JE Sale, JW Chin
Nature
(2023)
619
(doi: 10.1038/s41586-023-06268-1)
Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNAPyl pairs.
AT Beattie, DL Dunkelmann, JW Chin
Nat Chem
(2023)
15
(doi: 10.1038/s41557-023-01232-y)
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles
M Spinck, C Piedrafita, WE Robertson, TS Elliott, D Cervettini, D de la Torre, JW Chin
Nature chemistry
(2022)
15
(doi: 10.1038/s41557-022-01082-0)
Refactored genetic codes enable bidirectional genetic isolation
JF Zürcher, WE Robertson, T Kappes, G Petris, TS Elliott, GPC Salmond, JW Chin
Science
(2022)
378
(doi: 10.1126/science.add8943)
RBBP6 activates the pre-mRNA 3' end processing machinery in humans.
V Boreikaite, TS Elliott, JW Chin, LA Passmore
Genes & Development
(2022)
36
(doi: 10.1101/gad.349223.121)
Mechanism-based traps enable protease and hydrolase substrate discovery
S Tang, AT Beattie, L Kafkova, G Petris, N Huguenin-Dezot, M Fiedler, M Freeman, JW Chin
Nature
(2022)
602
(doi: 10.1038/s41586-022-04414-9)
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons
NJ Smyllie, J Bagnall, AA Koch, D Niranjan, L Polidarova, JE Chesham, JW Chin, CL Partch, ASI Loudon, MH Hastings
Proceedings of the National Academy of Sciences of the United States of America
(2022)
119
(doi: 10.1073/pnas.2113845119)
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites
F Bürmann, LFH Funke, JW Chin, J Löwe
Mol Cell
(2021)
81
(doi: 10.1016/j.molcel.2021.10.011)
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design.
DL Dunkelmann, SB Oehm, AT Beattie, JW Chin
Nature chemistry
(2021)
13
(doi: 10.1038/s41557-021-00764-5)

Research Group

Research Interest Group

Email address

chin@mrc-lmb.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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