Yusuf Hamied Department of Chemistry

Professor Jason Chin FMedSci FRS

Professor of Chemistry & Chemical Biology

Publications

Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNAPyl pairs.
AT Beattie, DL Dunkelmann, JW Chin
Nature chemistry
(2023)
15
(doi: 10.1038/s41557-023-01232-y)
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles
M Spinck, C Piedrafita, WE Robertson, TS Elliott, D Cervettini, D de la Torre, JW Chin
Nat Chem
(2022)
15
(doi: 10.1038/s41557-022-01082-0)
Refactored genetic codes enable bidirectional genetic isolation.
JF Zürcher, WE Robertson, T Kappes, G Petris, TS Elliott, GPC Salmond, JW Chin
Science
(2022)
378
(doi: 10.1126/science.add8943)
RBBP6 activates the pre-mRNA 3' end processing machinery in humans
V Boreikaite, TS Elliott, JW Chin, LA Passmore
Genes & development
(2022)
36
(doi: 10.1101/gad.349223.121)
Mechanism-based traps enable protease and hydrolase substrate discovery
S Tang, AT Beattie, L Kafkova, G Petris, N Huguenin-Dezot, M Fiedler, M Freeman, JW Chin
Nature
(2022)
602
(doi: 10.1038/s41586-022-04414-9)
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons.
NJ Smyllie, J Bagnall, AA Koch, D Niranjan, L Polidarova, JE Chesham, JW Chin, CL Partch, ASI Loudon, MH Hastings
Proc Natl Acad Sci U S A
(2022)
119
(doi: 10.1073/pnas.2113845119)
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites
F Bürmann, LFH Funke, JW Chin, J Löwe
Mol Cell
(2021)
81
(doi: 10.1016/j.molcel.2021.10.011)
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design
DL Dunkelmann, SB Oehm, AT Beattie, JW Chin
Nat Chem
(2021)
13
(doi: 10.1038/s41557-021-00764-5)
Precise optical control of gene expression in <i>C elegans</i> using improved genetic code expansion and Cre recombinase.
L Davis, I Radman, A Goutou, A Tynan, K Baxter, Z Xi, JM O'Shea, JW Chin, S Greiss
Elife
(2021)
10
(doi: 10.7554/eLife.67075)
Sense codon reassignment enables viral resistance and encoded polymer synthesis
WE Robertson, LFH Funke, D de la Torre, J Fredens, TS Elliott, M Spinck, Y Christova, D Cervettini, FL Böge, KC Liu, S Buse, S Maslen, GPC Salmond, JW Chin
Science
(2021)
372
(doi: 10.1126/science.abg3029)

Research Group

Research Interest Group

Email address

chin@mrc-lmb.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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