Professor Jason Chin FMedSci FRS

Professor of Chemistry & Chemical Biology

Publications

Escherichia coli with a 57-codon genetic code.

WE Robertson, FBH Rehm, M Spinck, RL Schumann, R Tian, W Liu, Y Gu, AA Kleefeldt, CF Day, KC Liu, Y Christova, JF Zürcher, FL Böge, J Birnbaum, L van Bijsterveldt, JW Chin

Science (New York, N.Y.)

(2025)

390

eady4368

(doi: 10.1126/science.ady4368)

Genetic Code-Locking Confers Stable Virus Resistance to a Recoded Organism.

JF Zürcher, A Dickson, T Kappes, AA Kleefeldt, KC Liu, GPC Salmond, JW Chin

Biochemistry

(2025)

3093

(doi: 10.1021/acs.biochem.5c00075)

Escherichia coli with a 57-codon genetic code

WE Robertson, FBH Rehm, M Spinck, RL Schumann, R Tian, W Liu, Y Gu, AA Kleefeldt, CF Day, KC Liu, Y Christova, JF Zürcher, FL Böge, J Birnbaum, L van Bijsterveldt, JW Chin

(2025)

(doi: 10.1101/2025.05.02.651837)

Automated orthogonal tRNA generation

M Spinck, A Guppy, JW Chin

Nature Chemical Biology

(2024)

657

(doi: 10.1038/s41589-024-01782-3)

Author Correction: Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS

WE Robertson, LFH Funke, D de la Torre, J Fredens, K Wang, JW Chin

Nature protocols

(2024)

(doi: 10.1038/s41596-024-01114-8)

Engineering Pyrrolysine Systems for Genetic Code Expansion and Reprogramming.

DL Dunkelmann, JW Chin

Chem Rev

(2024)

124

11008

(doi: 10.1021/acs.chemrev.4c00243)

Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification

J Luo, Y Yu, K Wang, S He, L Wang, F Liang, JW Chin, S Tang

Nature protocols

(2024)

2967

(doi: 10.1038/s41596-024-01006-x)

Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli

R Tian, FBH Rehm, D Czernecki, Y Gu, JF Zürcher, KC Liu, JW Chin

Science

(2024)

383

421

(doi: 10.1126/science.adk1281)

Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism

DL Dunkelmann, C Piedrafita, A Dickson, KC Liu, TS Elliott, M Fiedler, D Bellini, A Zhou, D Cervettini, JW Chin

Nature

(2024)

625

603

(doi: 10.1038/s41586-023-06897-6)

Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly.

JF Zürcher, AA Kleefeldt, LFH Funke, J Birnbaum, J Fredens, S Grazioli, KC Liu, M Spinck, G Petris, P Murat, FBH Rehm, JE Sale, JW Chin

Nature

(2023)

619

555

(doi: 10.1038/s41586-023-06268-1)

Professor Jason Chin FMedSci FRS

Professor of Chemistry & Chemical Biology

Publications

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About the Department

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Study at Cambridge

About the University

Research at Cambridge