Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Highlights from the 39th ESF/EUCHEM Conference on Stereochemistry, Bürgenstock, Switzerland, April 2004

CJ Hayes, DR Spring

Chem. Commun.

(2004)

10

2365

(doi: 10.1039/b409495f)

Diversity-oriented synthesis; a challenge for synthetic chemistsElectronic supplementary information (ESI) available: Excel file of all the FDA new molecular entities between the years 1998 and July 2003, and new drug approvals between the years 1990 and 2002. See http://www.rsc.org/suppdata/ob/b3/b310752n/

DR Spring

Organic & Biomolecular Chemistry

(2003)

1

3867

(doi: 10.1039/b310752n)

How diverse is your combinatorial library?

DR Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225

U280

Diversity-Oriented Synthesis of Biaryl-Containing Medium Rings Using a One Bead/One Stock Solution Platform

DR Spring, S Krishnan, HE Blackwell, SL Schreiber

J Am Chem Soc

(2002)

124

1354

(doi: 10.1021/ja017248o)

A one-bead, one-stock solution approach to chemical genetics: part 2.

PA Clemons, AN Koehler, BK Wagner, TG Sprigings, DR Spring, RW King, SL Schreiber, MA Foley

Chemistry & biology

(2001)

8

1183

(doi: 10.1016/s1074-5521(01)00086-2)

Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings

DR Spring, S Krishnan, SL Schreiber

Journal of the American Chemical Society

(2000)

122

5656

(doi: 10.1021/ja0010507)

Studies on the Biomimetic Synthesis of the Manzamine Alkaloids

JE Baldwin, TDW Claridge, AJ Culshaw, FA Heupel, V Lee, DR Spring, RC Whitehead

Chemistry - A European Journal

(1999)

5

3154

(doi: 10.1002/(sici)1521-3765(19991105)5:11<3154::aid-chem3154>3.0.co;2-7)

Investigations into the manzamine alkaloid biosynthetic hypothesis

JE Baldwin, TDW Claridge, AJ Culshaw, FA Heupel, V Lee, DR Spring, RC Whitehead, RJ Boughtflower, IM Mutton, RJ Upton

Angewandte Chemie International Edition

(1998)

37

2661

(doi: 10.1002/(SICI)1521-3773(19981016)37:19<2661::AID-ANIE2661>3.0.CO;2-D)

Efficient synthesis of the sponge alkaloids cyclostellettamines A-F

JE Baldwin, DR Spring, CE Atkinson, V Lee

Tetrahedron

(1998)

54

13655

(doi: 10.1016/s0040-4020(98)00842-4)

Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis

JE Baldwin, TDW Claridge, AJ Culshaw, FA Heupel, V Lee, DR Spring, RC Whitehead, RJ Boughtflower, IM Mutton, RJ Upton

Angew Chem Int Ed Engl

(1998)

37

2661

(doi: 10.1002/(sici)1521-3773(19981016)37:19<2661::aid-anie2661>3.0.co;2-d)