Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Diversity-Oriented Synthesis of Biaryl-Containing Medium Rings Using a One Bead/One Stock Solution Platform

DR Spring, S Krishnan, HE Blackwell, SL Schreiber

J Am Chem Soc

(2002)

124

1354

(doi: 10.1021/ja017248o)

A one-bead, one-stock solution approach to chemical genetics: part 2.

PA Clemons, AN Koehler, BK Wagner, TG Sprigings, DR Spring, RW King, SL Schreiber, MA Foley

Cell Chemical Biology

(2001)

8

1183

(doi: 10.1016/S1074-5521(01)00086-2)

Towards diversity-oriented, stereoselective syntheses of biaryl- or bis(aryl)metal-containing medium rings [11]

DR Spring, S Krishnan, SL Schreiber

Journal of the American Chemical Society

(2000)

122

5656

(doi: 10.1021/ja0010507)

Studies on the Biomimetic Synthesis of the Manzamine Alkaloids

JE Baldwin, TDW Claridge, AJ Culshaw, FA Heupel, V Lee, DR Spring, RC Whitehead

Chemistry - A European Journal

(1999)

5

3154

(doi: 10.1002/(sici)1521-3765(19991105)5:11<3154::aid-chem3154>3.0.co;2-7)

Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis

JE Baldwin, TDW Claridge, AJ Culshaw, FA Heupel, V Lee, DR Spring, RC Whitehead, RJ Boughtflower, IM Mutton, RJ Upton

Angewandte Chemie International Edition

(1998)

37

2661

(doi: 10.1002/(SICI)1521-3773(19981016)37:19<2661::AID-ANIE2661>3.0.CO;2-D)

Efficient synthesis of the sponge alkaloids cyclostellettamines A-F

JE Baldwin, DR Spring, CE Atkinson, V Lee

Tetrahedron

(1998)

54

13655

(doi: 10.1016/S0040-4020(98)00842-4)

Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis

JE Baldwin, TDW Claridge, AJ Culshaw, FA Heupel, V Lee, DR Spring, RC Whitehead, RJ Boughtflower, IM Mutton, RJ Upton

Angewandte Chemie International Edition

(1998)

37

2661

(doi: 10.1002/(sici)1521-3773(19981016)37:19<2661::aid-anie2661>3.0.co;2-d)

A novel Diels-Alder approach to hydroisoquinolines

JE Baldwin, DR Spring, RC Whitehead

Tetrahedron Letters

(1998)

39

5417

(doi: 10.1016/s0040-4039(98)01043-0)

A biomimetic approach to the manzamine alkaloids

DR Spring, JE Baldwin, RC Whitehead, L Bischoff, TDW Claridge

FASEB Journal

(1997)

11

A893

An approach to the manzamine alkaloids modelled on a biogenetic theory

JE Baldwin, L Bischoff, TDW Claridge, FA Heupel, DR Spring, RC Whitehead

Tetrahedron

(1997)

53

2271

(doi: 10.1016/S0040-4020(96)01129-5)