Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Gemmacin B: Bringing diversity back into focus

A Robinson, GL Thomas, RJ Spandl, M Welch, DR Spring

Organic and Biomolecular Chemistry

(2008)

6

2978

(doi: 10.1039/b809038f)

Diversity-oriented synthesis.

RJ Spandl, M Díaz-Gavilán, KMG O'Connell, GL Thomas, DR Spring

Chem Rec

(2008)

8

129

(doi: 10.1002/tcr.20144)

Exploiting domino enyne metathesis mechanisms for skeletal diversity generation.

RJ Spandl, H Rudyk, DR Spring

Chem Commun (Camb)

(2008)

3001

(doi: 10.1039/b807278g)

Editorial: the chemistry-biology interface.

D Spring

Chem Soc Rev

(2008)

37

1293

(doi: 10.1039/b808132h)

Total Synthesis of Sanguiin H-5

X Su, DS Surry, RJ Spandl, DR Spring

Organic Letters

(2008)

10

2593

(doi: 10.1021/ol8009545)

Anti-MRSA agent discovery using diversity-oriented synthesis

GL Thomas, RJ Spandl, FG Glansdorp, M Welch, A Bender, J Cockfield, JA Lindsay, C Bryant, DFJ Brown, O Loiseleur, H Rudyk, M Ladlow, DR Spring

Angew Chem Int Ed Engl

(2008)

47

2808

(doi: 10.1002/anie.200705415)

2-methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator

LYW Lee, T Hupfield, RL Nicholson, JT Hodgkinson, X Su, GL Thomas, GPC Salmond, M Welch, DR Spring

Molecular bioSystems

(2008)

4

505

(doi: 10.1039/b801563e)

Diversity-oriented synthesis; a spectrum of approaches and results.

RJ Spandl, A Bender, DR Spring

Organic and Biomolecular Chemistry

(2008)

6

1149

(doi: 10.1039/b719372f)

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

EE Wyatt, WR Galloway, GL Thomas, M Welch, O Loiseleur, AT Plowright, DR Spring

Chemical communications (Cambridge, England)

(2008)

4962

Learning the Language of Bacteria

JT Hodgkinson, M Welch, DR Spring

ACS Chemical Biology

(2007)

2

715

(doi: 10.1021/cb700227k)