Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?

WR Galloway, DR Spring

Expert opinion on drug discovery

(2009)

4

467

(doi: 10.1517/17460440902916606)

The discovery of antibacterial agents using diversity-oriented synthesis

WRJD Galloway, A Bender, M Welch, DR Spring

Chemical Communications

(2009)

2446

(doi: 10.1039/b816852k)

Synthesis of Unprecedented Scaffold Diversity

WRJD Galloway, M Diáz-Gavilán, A Isidro-Llobet, DR Spring

Angew Chem Int Ed Engl

(2009)

48

1194

(doi: 10.1002/anie.200805452)

Fluoride-free cross coupling using vinyldisiloxanes.

HF Sore, CM Boehner, SJF MacDonald, D Norton, DJ Fox, DR Spring

Organic & Biomolecular Chemistry

(2009)

7

1068

(doi: 10.1039/b900852g)

Towards quorum-quenching catalytic antibodies

PB Kapadnis, E Hall, M Ramstedt, WRJD Galloway, M Welch, DR Spring

Chemical communications (Cambridge, England)

(2008)

538

(doi: 10.1039/b819819e)

Using chemical probes to investigate the sub-inhibitory effects of azithromycin

FG Glansdorp, RJ Spandl, JE Swatton, O Loiseleur, M Welch, DR Spring

Organic and Biomolecular Chemistry

(2008)

6

4120

(doi: 10.1039/b813157k)

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

EE Wyatt, WRJD Galloway, GL Thomas, M Welch, O Loiseleur, AT Plowright, DR Spring

Chemical communications (Cambridge, England)

(2008)

4962

(doi: 10.1039/b812901k)

Synthesis of a biotin-labeled quorum-sensing molecule: Towards a general method for target identification

D Spring, R Spandl, R Nicholson, D Marsden, J Hodgkinson, X Su, G Thomas, G Salmond, M Welch

Synlett

(2008)

2008

2122

(doi: 10.1055/s-2008-1077978)

BIOL 47-Synthesis of a transition-state analog for the hydrolysis of N-acyl homoserine lactones

PB Kapadnis, E Hall, M Welch, DR Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2008)

236

ORGN 157-Diversity oriented synthesis: From linear aminoalkenes to complex cyclic scaffolds

M Diaz-Gavilan, K O'Connell, F Benfatti, DR Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2008)

236