Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator

LYW Lee, T Hupfield, RL Nicholson, JT Hodgkinson, X Su, GL Thomas, GPC Salmond, M Welch, DR Spring

Molecular BioSystems

(2008)

4

505

(doi: 10.1039/b801563e)

Diversity-oriented synthesis; a spectrum of approaches and results.

RJ Spandl, A Bender, DR Spring

Org Biomol Chem

(2008)

6

1149

(doi: 10.1039/b719372f)

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

EE Wyatt, WR Galloway, GL Thomas, M Welch, O Loiseleur, AT Plowright, DR Spring

Chemical communications (Cambridge, England)

(2008)

4962

Learning the language of bacteria.

JT Hodgkinson, M Welch, DR Spring

ACS Chem Biol

(2007)

2

715

(doi: 10.1021/cb700227k)

Learning the language of bacteria

JT Hodgkinson, M Welch, DR Spring

ACS Chemical Biology

(2007)

2

715

(doi: 10.1021/0700227k)

Fluorous tagged small molecule microarrays.

RL Nicholson, ML Ladlow, DR Spring

Chemical Communications

(2007)

3906

(doi: 10.1039/b712906h)

Design and chance in the self-assembly of macromolecules.

JAR Worrall, M Gorna, XY Pei, DR Spring, RL Nicholson, BF Luisi

Biochemical Society Transactions

(2007)

35

502

(doi: 10.1042/BST0350502)

Variations on a theme: Diverse N-acyl homoserine lactone-mediated quorum sensing mechanisms in Gram-negative bacteria

D Smith, JH Wang, JE Swatton, P Davenport, B Price, H Mikkelsen, H Stickland, K Nishikawa, N Gardiol, DR Spring, M Welch

Science Progress

(2007)

89 PART 3

167

(doi: 10.3184/003685006783238335)

Small-molecule screening: advances in microarraying and cell-imaging technologies.

RL Nicholson, M Welch, M Ladlow, DR Spring

ACS Chem Biol

(2007)

2

24

(doi: 10.1021/cb600321j)

Fluorous tagged small molecule microarrays (Chemical Communications (2007) (3906) DOI: 10.1039/b712906h)

RL Nicholson, ML Ladlow, DR Spring

Chemical Communications

(2007)

3966

(doi: 10.1039/b713867a)