Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Ratiometric fluorescent and colorimetric sensors for Cu²⁺ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu²⁺ displacement approach

Z Xu, J Pan, DR Spring, J Cui, J Yoon

Tetrahedron

(2010)

66

1678

(doi: 10.1016/j.tet.2010.01.008)

Zn2+-triggered amide tautomerization produces a highly Zn 2+-selective, cell-permeable, and ratiometric fluorescent sensor

Z Xu, KH Baek, HN Kim, J Cui, X Qian, DR Spring, I Shin, J Yoon

Journal of the American Chemical Society

(2010)

132

601

(doi: 10.1021/ja907334j)

Development of off-on fluorescent probes for heavy and transition metal ions.

Z Xu, SJ Han, C Lee, J Yoon, DR Spring

Chemical Communications

(2010)

46

1679

(doi: 10.1039/b924503k)

An Introduction to Diversity‐Oriented Synthesis

RJ Spandl, GL Thomas, M Diaz‐Gavilan, KMG O'Connell, DR Spring

(2009)

239

(doi: 10.1002/9780470749043.ch8)

Zn2+-Triggered Amide Tautomerization Produces a Highly Zn2+-Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor

Z Xu, K-H Baek, HN Kim, J Cui, X Qian, DR Spring, I Shin, J Yoon

J Am Chem Soc

(2009)

132

601

(doi: 10.1021/ja907334j)

Diversity-oriented synthesis of bicyclic and tricyclic alkaloids

M Díaz-Gavilán, WRJD Galloway, KMG O'Connell, JT Hodkingson, DR Spring

Chemical communications (Cambridge, England)

(2009)

46

776

(doi: 10.1039/b917965h)

The molecular basis of the host response to lipopolysaccharide.

CE Bryant, DR Spring, M Gangloff, NJ Gay

Nature Reviews Microbiology

(2009)

8

8

(doi: 10.1038/nrmicro2266)

Synthesis of Biaryl-Containing Medium-Ring Systems by Organocuprate Oxidation: Applications in the Total Synthesis of Ellagitannin Natural Products

X Su, G Thomas, W Galloway, D Surry, R Spandl, D Spring

Synthesis

(2009)

2009

3880

(doi: 10.1055/s-0029-1218154)

Mastering the Chemical Language of Bacteria

WRJD Galloway, JT Hodgkinson, M Welch, DR Spring

Chemistry and Biology

(2009)

16

913

(doi: 10.1016/j.chembiol.2009.09.006)

3D small-molecule microarrays.

DM Marsden, RL Nicholson, M Ladlow, DR Spring

Chemical communications (Cambridge, England)

(2009)

7107

(doi: 10.1039/b913665g)