Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Synthesis of a Biotin-Labeled Quorum-Sensing Molecule: Towards a General Method for Target Identification
D Spring, R Spandl, R Nicholson, D Marsden, J Hodgkinson, X Su, G Thomas, G Salmond, M Welch
Synlett
(2008)
2008
BIOL 47-Synthesis of a transition-state analog for the hydrolysis of N-acyl homoserine lactones
PB Kapadnis, E Hall, M Welch, DR Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2008)
236
ORGN 157-Diversity oriented synthesis: From linear aminoalkenes to complex cyclic scaffolds
M Diaz-Gavilan, K O'Connell, F Benfatti, DR Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2008)
236
Gemmacin B: bringing diversity back into focus
A Robinson, GL Thomas, RJ Spandl, M Welch, DR Spring
Org Biomol Chem
(2008)
6
Diversity‐oriented synthesis
RJ Spandl, M Díaz-Gavilán, KMG O'Connell, GL Thomas, DR Spring
Chemical Record
(2008)
8
Exploiting domino enyne metathesis mechanisms for skeletal diversity generation
RJ Spandl, H Rudyk, DR Spring
Chemical Communications
(2008)
Editorial: the chemistry-biology interface
D Spring
Chemical Society reviews
(2008)
37
Total synthesis of sanguiin H-5
X Su, DS Surry, RJ Spandl, DR Spring
Org Lett
(2008)
10
Anti-MRSA agent discovery using diversity-oriented synthesis
GL Thomas, RJ Spandl, FG Glansdorp, M Welch, A Bender, J Cockfield, JA Lindsay, C Bryant, DFJ Brown, O Loiseleur, H Rudyk, M Ladlow, DR Spring
Angew Chem Int Ed Engl
(2008)
47
2-methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator
LYW Lee, T Hupfield, RL Nicholson, JT Hodgkinson, X Su, GL Thomas, GPC Salmond, M Welch, DR Spring
Mol Biosyst
(2008)
4

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address