Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Experiments on the synthesis of tetracycline. Part 16. Improved photocyclic preparation of 12-keto-derivatives and their deprotection using benzeneseleninic anhydride
– J CHEM SOC PERK T 1
(1981)
1840
(doi: 10.1039/P19810001840)
Synthesis of substituted cis -decalins as potential insect antifeedants
– J CHEM SOC PERK T 1
(1981)
1516
(doi: 10.1039/p19810001516)
Oxygen atom transfer from iodylbenzene to diphenyl diselenide - a convenient method for dehydrogenation of steroidal 3-ketones
– Journal of the Chemical Society, Chemical Communications
(1981)
1044
(doi: 10.1039/C39810001044)
Synthesis of cinnamolide and polygodial
– Journal of the Chemical Society Chemical Communications
(1981)
507
(doi: 10.1039/c39810000507)
Diaryl telluroxides as new mild oxidising reagents
– Tetrahedron
(1981)
37,
213
(doi: 10.1016/0040-4020(81)85057-0)
A convenient preparation of 2-haloenones from enones using phenylselenium halides
– Tetrahedron Letters
(1981)
22,
3301
Synthesis of a trans-decalin as a potential insect antifeedant
– Journal of the Chemical Society, Chemical Communications
(1981)
1001
(doi: 10.1039/c39810001001)
Cyclisation reactions of alkenyl β-ketoesters involving a novel phenylseleno group migration
– Tetrahedron Letters
(1981)
22,
2601
Synthesis of euryfuran, valdiviolide, and confertifolin
– Tetrahedron Letters
(1981)
22,
4747
Synthesis of (±)warburganal
– Tetrahedron Letters
(1981)
22,
3909
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