Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of the northern hemisphere of the milbemycins using a new strategy for the formation of the C15 to C16 bond.
– Tetrahedron Letters
(1985)
26,
5837
The use of 3-acetoxy-1-trimethylsilylbutadiene in the synthesis of anthracyclinone derivatives
– Journal of the Chemical Society Perkin Transactions 1
(1984)
1847
(doi: 10.1039/p19840001847)
Fe2(co)g in tetrahydrofuran or under sonochemical conditions as convenient practical routes to π-allyltricarbonyliron lactone complexes
– Tetrahedron
(1984)
40,
1737
Synthesis of spiroacetals using organoselenium-mediated cyclisation reactions. X-Ray molecular structure of (2S,8R)-8-methyl-2-phenyl-1,7-dioxaspiro[5.5]undecan-4(R)-ol
– J CHEM SOC PERK T 1
(1984)
1371
(doi: 10.1039/p19840001371)
Synthesis of the spiroacetal unit related to the avermectins and milbemycins
– Journal of the Chemical Society, Chemical Communications
(1984)
1381
(doi: 10.1039/c39840001381)
π-allyltricarbonyliron lactone complexes in synthesis: Application to the synthesis of the β-lactam antibiotic (+)-thienamycin
– Chemical Communications
(1984)
494
(doi: 10.1039/c39840000494)
Synthesis of (±)- cis -6-methyltetrahydropyran-2-ylacetic acid, a natural product from Viverra civetta , using organoselenium-mediated cyclisation reactions
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1984)
2403
(doi: 10.1039/P19840002403)
Oxo complexes of ruthenium(VI) and (VII) as organic oxidants
– J CHEM SOC PERK T 1
(1984)
681
(doi: 10.1039/p19840000681)
A new route to spiro-ketals using the Horner-Wittig reaction of 2-diphenylphosphinoxy cyclic ethers
– Tetrahedron Letters
(1984)
25,
113
Novel rearrangement of the ionophore antibiotic X-14547A (indanomycin) and related derivatives induced by lithium tetrafluoroborate
– Journal of the Chemical Society, Perkin Transactions 1
(1984)
1761
(doi: 10.1039/p19840001761)
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