Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

FE2(CO)9 IN TETRAHYDROFURAN OR UNDER SONOCHEMICAL CONDITIONS AS CONVENIENT PRACTICAL ROUTES TO PI-ALLYLTRICARBONYLIRON LACTONE COMPLEXES

AM Horton, DM Hollinshead, SV Ley

Tetrahedron

(1984)

1737

(doi: 10.1016/S0040-4020(01)91124-X)

Synthesis of (±)-cis-6-methyltetrahydropyran-2-ylacetic acid, a natural product from Viverra civetta, using organoselenium-mediated cyclisation reactions

SV Ley, B Lygo, H Molines

Journal of the Chemical Society Perkin Transactions 1

(1984)

2403

(doi: 10.1039/P19840002403)

The use of 3-acetoxy-1-trimethylsilylbutadiene in the synthesis of anthracyclinone derivatives

PC Bulman-Page, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1984)

1847

(doi: 10.1039/p19840001847)

Synthesis of spiroacetals using organoselenium-mediated cyclisation reactions. X -Ray molecular structure of (2 S ,8 R )-8-methyl-2-phenyl-1,7-dioxaspiro[5.5]undecan-4( R )-ol

AM Doherty, SV Ley, B Lygo, DJ Williams

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1984)

1371

(doi: 10.1039/p19840001371)

Oxo complexes of ruthenium( VI ) and ( VII ) as organic oxidants

G Green, WP Griffith, DM Hollinshead, SV Ley, M Schröder

J CHEM SOC PERK T 1

(1984)

681

(doi: 10.1039/p19840000681)

Synthesis of β-lactams from π-allyltricarbonyliron (lactone) complexes

GD Annis, EM Hebblethwaite, ST Hodgson, DM Hollinshead, SV Ley

J. Chem. Soc., Perkin Trans. 1

(1983)

2851

(doi: 10.1039/p19830002851)

The Diels-Alder route to drimane related sesquiterpenes; synthesis of cinnamolide, polygodial, isodrimeninol, drimenin and warburganal

DM Hollinshead, SC Howell, SV Ley, M Mahon, NM Ratcliffe, PA Worthington

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1983)

1579

(doi: 10.1039/p19830001579)

Synthesis of the drimane-related sesquiterpenes euryfuran, confertifolin, and valdiviolide

SV Ley, M Mahon

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1983)

1379

(doi: 10.1039/p19830001379)

The total synthesis of the clerodane diterpene insect antifeedant ajugarin I

SV Ley, NS Simpkins, AJ Whittle

Chemical Communications

(1983)

503

(doi: 10.1039/c39830000503)

Peterson olefination using phenylsulphonyltrimethylsilylmethane. A new preparation of vinylic sulphones

SV Ley, NS Simpkins

Journal of the Chemical Society Chemical Communications

(1983)

1281

(doi: 10.1039/c39830001281)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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