Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
X -Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
– Journal of the Chemical Society, Chemical Communications
(1986)
1,
46
(doi: 10.1039/c39860000046)
ALKYLATION REACTIONS OF ANIONS DERIVED FROM 2-BENZENESULFONYL TETRAHYDROPYRAN AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS
– Tetrahedron
(1986)
42,
4333
Ultrasonic formation and reactions of sodium phenylselenide
– Tetrahedron
(1986)
42,
5363
Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole
– Tetrahedron
(1986)
42,
3723
Preparation of spiroketals by reaction of anions from 2-benzenesulphonyltetrahydropyrans with epoxides: synthesis of the c-11 to c-25 fragment of the milbemycins
– Tetrahedron Letters
(1986)
27,
5277
SYNTHETIC STUDIES TOWARDS THE ACYLTETRONIC ACID IONOPHORE M-139603
– Tetrahedron Letters
(1986)
27,
105
Synthestic approaches to the teleocidin-related tumour promoters: a total synthesis of (±)-indolactam V
– Chemical Communications
(1986)
344
(doi: 10.1039/C39860000344)
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
– Tetrahedron
(1986)
42,
6519
The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction
– J CHEM SOC PERK T 1
(1986)
303
(doi: 10.1039/p19860000303)
Natural product synthesis using π-allyltricarbonyliron lactone complexes: Synthesis of parasorbic acid, the carpenter bee pheromone and malyngolide
– Journal of Organometallic Chemistry
(1985)
285,
C17
(doi: 10.1016/0022-328X(85)87394-0)
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