Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A conformational study of bafilomycin A1 by x-ray crystallography and nmr techniques
– Tetrahedron Letters
(1987)
28,
5565
An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
– Tetrahedron
(1987)
43,
2805
Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins.
– Tetrahedron Letters
(1987)
28,
5755
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
– Tetrahedron Letters
(1987)
28,
1595
Development of a synthetic route towards milbemycin β1: Preparation of an advanced model system.
– Tetrahedron Letters
(1987)
28,
5763
Microbial oxidation in synthesis: A six step perparation of (+)-pinitol from benzene
– Tetrahedron Letters
(1987)
28,
225
Use of S -t-butyl acetothioacetate in the preparation of milbemycin seco-analogues
– Journal of the Chemical Society Perkin Transactions 1
(1987)
131
(doi: 10.1039/p19870000131)
Application of ultrasound to the preparation of tricarbonyliron diene complexes
– Journal of Organometallic Chemistry
(1986)
302,
C13
(doi: 10.1016/0022-328x(86)80072-9)
X-Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
– Chemical Communications
(1986)
1,
46
(doi: 10.1039/C39860000046)
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