Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone

D Craig, SV Ley, NS Simpkins, GH Whitham, MJ Prior

J CHEM SOC PERK T 1

(1985)

1949

(doi: 10.1039/p19850001949)

SYNTHESIS OF THE NORTHERN HEMISPHERE OF THE MILBEMYCINS USING A NEW STRATEGY FOR THE FORMATION OF THE C-15 TO C-16 BOND

D Culshaw, P Grice, SV Ley, GA Strange

Tetrahedron Letters

(1985)

5837

(doi: 10.1016/s0040-4039(00)98940-8)

Preparation and reactions of 2-benzenesulphonyltetrahydropyran

SV Ley, B Lygo, A Wonnacott

Tetrahedron Letters

(1985)

535

(doi: 10.1016/s0040-4039(00)61931-7)

The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides

CMJ Fox, SV Ley, AMZ Slawin, DJ Williams

Journal of the Chemical Society Chemical Communications

(1985)

1805

(doi: 10.1039/c39850001805)

Structural reappraisal of the limonoid insect antifeedant azadirachtin

JN Bilton, HB Broughton, SV Ley, Z Lidert, ED Morgan, HS Rzepa, RN Sheppard

Journal of the Chemical Society, Chemical Communications

(1985)

968

(doi: 10.1039/c39850000968)

π-allyltricarbonyliron lactone complexes in synthesis: Application to the synthesis of the β-lactam antibiotic (+)-thienamycin

ST Hodgson, DM Hollinshead, SV Ley

Journal of the Chemical Society Chemical Communications

(1984)

494

(doi: 10.1039/C39840000494)

Oxo complexes of ruthenium(VI) and (VII) as organic oxidants

G Green, WP Griffith, DM Hollinshead, SV Ley, M Schröder

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1984)

681

(doi: 10.1039/p19840000681)

A NEW ROUTE TO SPIRO-KETALS USING THE HORNER-WITTIG REACTION OF 2-DIPHENYLPHOSPHINOXY CYCLIC ETHERS

SV Ley, B Lygo

Tetrahedron Letters

(1984)

113

(doi: 10.1016/S0040-4039(01)91163-3)

The use of 3-acetoxy-1-trimethylsilylbutadiene in the synthesis of anthracyclinone derivatives

PC Bulman-Page, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1984)

1847

(doi: 10.1039/p19840001847)

FE2(CO)9 IN TETRAHYDROFURAN OR UNDER SONOCHEMICAL CONDITIONS AS CONVENIENT PRACTICAL ROUTES TO PI-ALLYLTRICARBONYLIRON LACTONE COMPLEXES

AM Horton, DM Hollinshead, SV Ley

Tetrahedron

(1984)

1737

(doi: 10.1016/s0040-4020(01)91124-x)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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