Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

CORRECTION

SV LEY

– TETRAHEDRON LETT

(1987)

28,

1594

(link to publication)

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant

SV Ley, D Santafianos, WM Blaney, MSJ Simmonds

– Tetrahedron Letters

(1987)

28,

1595

(doi: 10.1016/s0040-4039(00)95369-3)

PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES

SV LEY, PR WOODWARD

– Tetrahedron Letters

(1987)

28,

345

(doi: 10.1016/s0040-4039(00)95725-3)

Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins.

NJ ANTHONY, T CLARKE, AB JONES, SV LEY

– Tetrahedron Letters

(1987)

28,

5755

(doi: 10.1016/S0040-4039(00)96833-3)

The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides

SV LEY, PR WOODWARD

– Tetrahedron Letters

(1987)

28,

3019

(doi: 10.1016/s0040-4039(00)96273-7)

An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives

JN BILTON, HB BROUGHTON, PS JONES, SV LEY, Z LIDERT, ED MORGAN, HS RZEPA, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS

– Tetrahedron

(1987)

43,

2805

(doi: 10.1016/s0040-4020(01)86886-1)

SYNTHESIS OF A NOVEL 3,4-DIHYDROMILBEMYCIN ANALOG

C GRECK, P GRICE, AB JONES, SV LEY

– Tetrahedron Letters

(1987)

28,

5759

(doi: 10.1016/s0040-4039(00)96834-5)

A CONFORMATIONAL STUDY OF BAFILOMYCIN-A1 BY X-RAY CRYSTALLOGRAPHY AND NMR TECHNIQUES

GH BAKER, PJ BROWN, RJJ DORGAN, JR EVERETT, SV LEY, AMZ SLAWIN, DJ WILLIAMS

– Tetrahedron Letters

(1987)

28,

5565

(doi: 10.1016/s0040-4039(00)96783-2)

Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues

T CLARKE, SV LEY

– J CHEM SOC PERK T 1

(1987)

131

(doi: 10.1039/p19870000131)

Application of ultrasound to the preparation of tricarbonyliron diene complexes

SV LEY, CMR LOW, AD WHITE

– Journal of Organometallic Chemistry

(1986)

302,

C13

(doi: 10.1016/0022-328x(86)80072-9)