Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

PREPARATION OF CYCLIC ETHER ACETALS FROM 2-BENZENESULFONYL DERIVATIVES - A NEW MILD GLYCOSIDATION PROCEDURE

DS BROWN, SV LEY, S VILE

– Tetrahedron Letters

(1988)

29,

4873

(doi: 10.1016/S0040-4039(00)80631-0)

MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION FROM BENZENE OF THE CELLULAR SECONDARY MESSENGER MYO-INOSITOL-1,4,5-TRISPHOSPHATE (IP3) AND RELATED DERIVATIVES

SV LEY, F STERNFELD

– Tetrahedron Letters

(1988)

29,

5305

(doi: 10.1016/S0040-4039(00)80744-3)

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .2. SYNTHESIS OF A POLYOXYGENATED DECALIN WITH LIMONOID STRUCTURAL HOMOLOGY

MG BRASCA, HB BROUGHTON, D CRAIG, SV LEY, AA SOMOVILLA, PL TOOGOOD

– Tetrahedron Letters

(1988)

29,

1853

(doi: 10.1016/s0040-4039(00)82062-6)

Use of t-butyl 4-diethylphosphono-3-oxobutanethioate for tetramic acid synthesis: Total synthesis of the plasmodial pigment fuligorubin A

SV LEY, SC SMITH, PR WOODWARD

– Tetrahedron Letters

(1988)

29,

5829

(doi: 10.1016/s0040-4039(00)82204-2)

Preparation and use of tetra-n-butylammonium per-ruthenate (TBAP reagent) and tetra-n-propylammonium per-ruthenate (TPAP reagent) as new catalytic oxidants for alcohols

WP GRIFFITH, SV LEY, GP WHITCOMBE, AD WHITE

– Journal of the Chemical Society, Chemical Communications

(1987)

1625

(doi: 10.1039/C39870001625)

Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues

T CLARKE, SV LEY

– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1987)

131

(doi: 10.1039/p19870000131)

PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES