Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
Tetrahedron
(1986)
42
6519
Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal syntiesis
Tetrahedron
(1986)
42
4333
Ultrasonic formation and reactions of sodium phenylselenide
Tetrahedron
(1986)
42
5363
Natural product synthesis using π-allyltricarbonyliron lactone complexes: Synthesis of parasorbic acid, the carpenter bee pheromone and malyngolide
Journal of Organometallic Chemistry
(1985)
285
C17
(doi: 10.1016/0022-328X(85)87394-0)
ORGANOSELENIUM-MEDIATED CYCLISATION REACTIONS IN ORGANIC SYNTHESIS.
Chemistry and Industry London
(1985)
101
Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction
Tetrahedron
(1985)
41
4765
Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex
Tetrahedron
(1985)
41
5871
WITTIG AND HORNER-WITTIG COUPLING REACTIONS OF 2-SUBSTITUTED CYCLIC ETHERS AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS
Tetrahedron
(1985)
41
3825
SYNTHETIC APPLICATIONS OF YNES, ENES AND ONES - ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS IN ORGANIC-SYNTHESIS
CHEM IND-LONDON
(1985)
101
Use of π-allyltricarbonyliron lactam complexes in the preparation of nocardicin derivatives: synthesis of (–)-3-oxo-1-[( p -benzyloxyphenyl)-benzyloxycarbonylmethyl]azetidin-2-one
Journal of the Chemical Society Perkin Transactions 1
(1985)
2375
(doi: 10.1039/P19850002375)
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