Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
PREPARATION OF TERT-BUTYL ACETOTHIOACETATE AND USE IN THE SYNTHESIS OF 3-ACETYL-4-HYDROXY-5,5-DIMETHYLFURAN-2(5H)-ONE
– ORG SYNTH
(1988)
66,
108
Chemistry of insect antifeedants from azadirachta indica (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology.
– Tetrahedron Letters
(1988)
29,
1853
Chemistry of insect antifeedants from azadirachta indica (part 3): reactions on the C-22,23 enol ether double bond of azadirachtin and conversion to 22,23-dihydro-23-β-methoxyazadirachtin.
– Tetrahedron Letters
(1988)
29,
5433
Use of t-butyl 4-diethylphosphono-3-oxobutanethioate for tetramic acid synthesis: Total synthesis of the plasmodial pigment fuligorubin A
– Tetrahedron Letters
(1988)
29,
5829
Preparation and use of tetra-n-butylammonium per-ruthenate (TBAP reagent) and tetra-n-propylammonium per-ruthenate (TPAP reagent) as new catalytic oxidants for alcohols
– Journal of the Chemical Society Chemical Communications
(1987)
1625
(doi: 10.1039/C39870001625)
Microbial oxidation in synthesis: A six step perparation of (+)-pinitol from benzene
– Tetrahedron Letters
(1987)
28,
225
An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
– Tetrahedron
(1987)
43,
2805
Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1987)
131
(doi: 10.1039/p19870000131)
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
– Tetrahedron Letters
(1987)
28,
221
Preparation of acyltetronic acids using t-butyl acetothioacetate: Total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
– Journal of the Chemical Society, Perkin Transactions 1
(1987)
121
(doi: 10.1039/p19870000121)
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