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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Microbial Oxidation in Synthesis: Preparation of (+)- and (-)-Pinitol from Benzene
SV LEY, F STERNFELD
– Tetrahedron
(1989)
45,
3463
(doi: 10.1016/S0040-4020(01)81025-5)
The antifeedant activity of clerodane diterpenoids from Teucrium
MSJ SIMMONDS, WM BLANEY, SV LEY, G SAVONA, M BRUNO, B RODRIGUEZ
– Phytochemistry
(1989)
28,
1069
(doi: 10.1016/0031-9422(89)80184-0)
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION OF 6-DEOXY CYCLITOL ANALOGS OF MYOINOSITOL 1,4,5-TRISPHOSPHATE FROM BENZENE
SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD, A VIDAL
– Tetrahedron Letters
(1989)
30,
3557
(doi: 10.1016/S0040-4039(00)99439-5)
Direct substitution of 2-benzenesulphonyl cyclic ethers using organozinc reagents
DS BROWN, SV LEY
– Tetrahedron Letters
(1988)
29,
4869
(doi: 10.1016/S0040-4039(00)80630-9)
Chemistry of insect antifeedants from azadirachta indica (part 1): Conversion from the azadirachtin to the azadirachtinin skeletons
JN BILTON, PS JONES, SV LEY, NG ROBINSON, RN SHEPPARD
– Tetrahedron Letters
(1988)
29,
1849
(doi: 10.1016/S0040-4039(00)82061-4)
PREPARATION OF TERT-BUTYL ACETOTHIOACETATE AND USE IN THE SYNTHESIS OF 3-ACETYL-4-HYDROXY-5,5-DIMETHYLFURAN-2(5H)-ONE
CMJ FOX, SV LEY
– ORG SYNTH
(1988)
66,
108
(link to publication)
PREPARATION OF CYCLIC ETHER ACETALS FROM 2-BENZENESULFONYL DERIVATIVES - A NEW MILD GLYCOSIDATION PROCEDURE
DS BROWN, SV LEY, S VILE
– Tetrahedron Letters
(1988)
29,
4873
(doi: 10.1016/s0040-4039(00)80631-0)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .3. REACTIONS ON THE C-22,23 ENOL ETHER DOUBLE-BOND OF AZADIRACHTIN AND CONVERSION TO 22,23-DIHYDRO-23-BETA-METHOXYAZADIRACHTIN
SV LEY, JC ANDERSON, WM BLANEY, Z LIDERT, ED MORGAN, NG ROBINSON, MSJ SIMMONDS
– Tetrahedron Letters
(1988)
29,
5433
(doi: 10.1016/S0040-4039(00)82888-9)
Use of t-butyl 4-diethylphosphono-3-oxobutanethioate for tetramic acid synthesis: Total synthesis of the plasmodial pigment fuligorubin A
SV LEY, SC SMITH, PR WOODWARD
– Tetrahedron Letters
(1988)
29,
5829
(doi: 10.1016/s0040-4039(00)82204-2)
Chemistry of insect antifeedants from azadirachta indica (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology.
MG BRASCA, HB BROUGHTON, D CRAIG, SV LEY, AA SOMOVILLA, PL TOOGOOD
– Tetrahedron Letters
(1988)
29,
1853
(doi: 10.1016/S0040-4039(00)82062-6)
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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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