skip to content
Home

Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

The antifeedant activity of clerodane diterpenoids from Teucrium
MSJ SIMMONDS, WM BLANEY, SV LEY, G SAVONA, M BRUNO, B RODRIGUEZ
– Phytochemistry
(1989)
28,
1069
(doi: 10.1016/0031-9422(89)80184-0)
Preparation of β-ketomacrolactones and β-ketodiolides using S-t-butyl 3-oxobutanethioate and S-t-butyl 4-diethylphosphono-3-oxobutanethioate
PM BOOTH, HB BROUGHTON, MJ FORD, CMJ FOX, SV LEY, AMZ SLAWIN, DJ WILLIAMS, PR WOODWARD
– Tetrahedron
(1989)
45,
7565
(doi: 10.1016/S0040-4020(01)89218-8)
Microbial Oxidation in Synthesis: Preparation of (+)- and (−)-Pinitol from Benzene
SV LEY, F STERNFELD
– Tetrahedron
(1989)
45,
3463
(doi: 10.1016/S0040-4020(01)81025-5)
Substitution Reactions of 2-Benzensulphonyl Cyclic Ethers with Silyl Enol Ethers Promoted by Aluminium Trichloride
DS BROWN, SV LEY, M BRUNO
– Heterocycles
(1989)
28,
773
(doi: 10.3987/com-88-s145)
The structure of two new clerodane diterpenoid potent insect antifeedants from Scutellaria woronowii (Juz); jodrellin A & B
JC ANDERSON, WM BLANEY, MD COLE, LL FELLOWS, SV LEY, RN SHEPPARD, MSJ SIMMONDS
– Tetrahedron Letters
(1989)
30,
4737
(doi: 10.1016/s0040-4039(01)80789-9)
The first crystal and molecular structure of lanthanide homodinuclear macrocyclic complexes showing metal-metal pair interactions
IA KAHWA, S FOLKES, DJ WILLIAMS, SV LEY, CA OMAHONEY, GL MCPHERSON
– Chemical Communications
(1989)
1531
(doi: 10.1039/C39890001531)
Chemistry of insect antifeedants from azadirachta indica (part 4): synthesis towards the limonoid azadirachtin; preparation of a functionalised decalin fragment
SV LEY, AA SOMOVILLA, HB BROUGHTON, D CRAIG, AMZ SLAWIN, PL TOOGOOD, DJ WILLIAMS
– Tetrahedron
(1989)
45,
2143
(doi: 10.1016/s0040-4020(01)80075-2)
SUBSTITUTION-REACTIONS OF 2-BENZENESULFONYL CYCLIC ETHERS WITH CARBON NUCLEOPHILES
DS BROWN, M BRUNO, RJ DAVENPORT, SV LEY
– Tetrahedron
(1989)
45,
4293
(doi: 10.1016/S0040-4020(01)81323-5)
Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene
SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD, A VIDAL
– Tetrahedron Letters
(1989)
30,
3557
(doi: 10.1016/S0040-4039(00)99439-5)
Insect antifeedants from azadirachta indica (part 5): Chemical modification and structure-activity relationships of azadirachtin and some related limonoids
SV LEY, JC ANDERSON, WM BLANEY, PS JONES, Z LIDERT, ED MORGAN, NG ROBINSON, D SANTAFIANOS, MSJ SIMMONDS, PL TOOGOOD
– Tetrahedron
(1989)
45,
5175
(doi: 10.1016/S0040-4020(01)81095-4)
  • <
  • 91 of 105
  • >

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

    Study at Cambridge

    About the University

    Research at Cambridge