Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Total Synthesis of Avermectin B1a: Final Coupling Reactions and the Total Synthesis of Avermectin B1a Aglycone
– Synlett
(1990)
1990,
328
(doi: 10.1055/s-1990-21080)
Total Synthesis of Avermectin B1a: Synthesis of the Carbohydrate Bis-Oleandrose Fragment and Coupling to the Avermectin B1a Aglycone
– Synlett
(1990)
1990,
331
(doi: 10.1055/s-1990-21081)
Total Synthesis of Avermectin B1a: Planning of the Synthesis and Preparation of the C1-C10 "Southern" Hydrobenzofuran Fragment
– Synlett
(1990)
1990,
323
(doi: 10.1055/s-1990-21078)
A Simple, One-Pot, Glycosidation Procedurevia(1-Imidazolylcaronyl) Glycosides and Zinc Bromide
– Synlett
(1990)
1990,
255
(doi: 10.1055/s-1990-21053)
Alkenylcyclic Sulphites as Novel Precursors for the Preparation of π-Allyltricarbonyliron Lactone Complexes
– Synlett
(1990)
1990,
224
(doi: 10.1055/s-1990-21044)
TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols
– Aldrichimica Acta
(1990)
23,
13
Chemistry of insect antifeedants from azadirachta indica (part 7): Preparation of an optically pure hydroxyacetal epoxide related to azadirachtin.
– Tetrahedron Letters
(1990)
31,
3437
Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a
– Tetrahedron Letters
(1990)
31,
3445
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