Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Microbial oxidation in synthesis: Concise preparation of (+)-conduritol F from benzene
– Synlett
(1990)
1990,
393
(doi: 10.1055/s-1990-21102)
TOTAL SYNTHESIS OF AVERMECTIN B1A - FINAL COUPLING REACTIONS AND THE TOTAL SYNTHESIS OF AVERMECTIN B1A AGLYCONE
– Synlett
(1990)
1990,
328
(doi: 10.1055/s-1990-21080)
Total Synthesis of Avermectin B1a: Synthesis of the C11-C25 Spiroacetal Fragment
– Synlett
(1990)
1990,
326
(doi: 10.1055/s-1990-21079)
Total Synthesis of Avermectin B1a: Synthesis of the CarbohydrateBis-Oleandrose Fragment and Coupling to the Avermectin B1a Aglycone
– Synlett
(1990)
1990,
331
(doi: 10.1055/s-1990-21081)
Total Synthesis of Avermectin B1a: Planning of the Synthesis and Preparation of the C1-C10 »southern» Hydrobenzofuran Fragment
– Synlett
(1990)
1990,
323
(doi: 10.1055/s-1990-21078)
A Simple, One-Pot, Glycosidation Procedure via (1-Imidazolylcaronyl) Glycosides and Zinc Bromide
– Synlett
(1990)
1990,
255
(doi: 10.1055/s-1990-21053)
Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae.
– Entomologia Experimentalis et Applicata.
(1990)
55,
149
Alkenylcyclic sulphites as novel precursors for the preparation of π-allyltricarbonyliron lactone complexes
– Synlett
(1990)
1990,
224
(doi: 10.1055/s-1990-21044)
Direct Substitution of 2-Benzenesulphonylpiperidines and -pyrrolidines by Carbon Nucleophiles: Synthesis of the Pyrrolidine Alkaloid Ruspolinone
– Synlett
(1990)
1990,
48
(doi: 10.1055/s-1990-20983)
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