Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The structure of two new clerodane diterpenoid potent insect antifeedants from Scutellaria woronowii (Juz); jodrellin A & B
Tetrahedron Letters
(1989)
30
4737
Microbial Oxidation in Synthesis: Preparation of (+)- and (-)-Pinitol from Benzene
Tetrahedron
(1989)
45
3463
Substitution Reactions of 2-Benzensulphonyl Cyclic Ethers with Silyl Enol Ethers Promoted by Aluminium Trichloride
Heterocycles
(1989)
28
773
(doi: 10.3987/com-88-s145)
The first crystal and molecular structure of lanthanide homodinuclear macrocyclic complexes showing metal–metal pair interactions
J. Chem. Soc., Chem. Commun.
(1989)
1531
(doi: 10.1039/C39890001531)
ASSEMBLY OF THE T-CELL RECEPTOR CD3 COMPLEX
PROGRESS IN IMMUNOLOGY, VOL 7
(1989)
33
A HIGHLY CONVERGENT TOTAL SYNTHESIS OF THE SPIROACETAL MACROLIDE (+)-MILBEMYCIN BETA-1
Tetrahedron
(1989)
45
7161
The antifeedant activity of clerodane diterpenoids from Teucrium
Phytochemistry
(1989)
28
1069
(doi: 10.1016/0031-9422(89)80184-0)
Insect antifeedants from azadirachta indica (part 5): Chemical modification and structure-activity relationships of azadirachtin and some related limonoids
Tetrahedron
(1989)
45
5175
PREPARATION OF BETA-KETOMACROLACTONES AND BETA-KETODIOLIDES USING S-TERT-BUTYL 3-OXOBUTANETHIOATE AND S-TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE
Tetrahedron
(1989)
45
7565
Organic synthesis with tricarbonyliron lactone complexes
Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences
(1988)
326
633
(doi: 10.1098/rsta.1988.0114)
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