Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

SYNTHESIS OF ANTIFEEDANTS FOR INSECTS - NOVEL BEHAVIOR-MODIFYING CHEMICALS FROM PLANTS

SV LEY

CIBA FOUNDATION SYMPOSIA

(1990)

154

Direct substitution of 2-benzenesulphonylpiperidines and - Pyrrolidines by carbon nucleophiles: Synthesis of the pyrrolidine alkaloid ruspolinone

D Brown*, T Hansson, S Ley

Synlett

(1990)

1990

(doi: 10.1055/s-1990-20983)

ASSESSMENT OF BUTENE-1,4-DIOLS AS STARTING MATERIALS FOR THE PREPARATION OF PI-ALLYLTRICARBONYLIRON COMPLEXES

RW Bates, D Díez-Martín, WJ Kerr, JG Knight, SV Ley, A Sakellaridis

Tetrahedron

(1990)

4063

(doi: 10.1016/s0040-4020(01)90541-1)

INSECT ANTIFEEDANTS

SV LEY, PL TOOGOOD

CHEMISTRY IN BRITAIN

(1990)

Total synthesis of (+)-milbemycin β1

NJ Anthony, A Armstrong, SV Ley, A Madin

Tetrahedron Letters

(1989)

3209

(doi: 10.1016/S0040-4039(00)99203-7)

A HIGHLY CONVERGENT TOTAL SYNTHESIS OF THE SPIROACETAL MACROLIDE (+)-MILBEMYCIN BETA-1

SV Ley, NJ Anthony, A Armstrong, MG Brasca, T Clarke, D Culshaw, C Greck, P Grice, AB Jones, B Lygo, A Madin, RN Sheppard, AMZ Slawin, DJ Williams

Tetrahedron

(1989)

7161

(doi: 10.1016/S0040-4020(01)89182-1)

PREPARATION OF BETA-KETOMACROLACTONES AND BETA-KETODIOLIDES USING S-TERT-BUTYL 3-OXOBUTANETHIOATE AND S-TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE

PM Booth, HB Broughton, MJ Ford, CMJ Fox, SV Ley, AMZ Slawin, DJ Williams, PR Woodward

Tetrahedron

(1989)

7565

(doi: 10.1016/s0040-4020(01)89218-8)