Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Microbial Oxidation in Synthesis: Preparation of Novel 3-Substituted cis-Cyclohexa-3,5-diene-1,2-diol Derivatives from (1S,2S)-3-Bromocyclohexa-3,5-diene-1,2-diol
– Synlett
(1991)
1991,
741
(doi: 10.1055/s-1991-34764)
SYNTHESIS OF TETRAHYDROPYRAN-CONTAINING NATURAL-PRODUCTS
– HETEROCYCLES IN BIO-ORGANIC CHEMISTRY
(1991)
1
DIRECT SUBSTITUTION OF 2-PHENYLSULPHONYLPYRROLIDINES, 2-PHENYLSULPHONYLPIPERIDINES, 2-PHENYLSULPHONYLTETRAHYDROFURANS AND 2-PHENYLSULPHONYLTETRAHYDROPYRANS BY ALKYL ORGANOMETALLIC REAGENTS IN DICHLOROMETHANE
– SYNLETT
(1990)
749
An efficient three-step synthesis of L-(-)-oleandrose from (S)-(-)-methyl lactate
– Synlett
(1990)
1990,
771
(doi: 10.1055/s-1990-21247)
Direct Substitution of 2-Phenylsulphonylpyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by Alkyl Organometallic Reagents in Dichloromethane
– Synlett
(1990)
1990,
749
(doi: 10.1055/s-1990-21237)
A NEW RUTHENIUM(VI) OXIDANT - PREPARATION, X-RAY CRYSTAL-STRUCTURE, AND PROPERTIES OF (PH4P)[RUO2(OAC)CL2]
– Chemical Communications
(1990)
1219
(doi: 10.1039/c39900001219)
NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES
– ABSTR PAP AM CHEM S
(1990)
200,
55
USE OF MICROBIAL OXIDANTS FOR THE PREPARATION OF INOSITOL DERIVATIVES AND RELATED CYCLITOLS
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1990)
200,
123
SYNTHESIS OF BIOLOGICALLY-ACTIVE CYCLITOLS VIA MICROBIAL OXIDATION OF BENZENE
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1990)
200,
42
Microbial oxidation in synthesis: Concise preparation of (+)-conduritol F from benzene
– Synlett
(1990)
1990,
393
(doi: 10.1055/s-1990-21102)
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