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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Chapter 7 The Champagne Route to Avermectins and Milbemycins
SV Ley, A Armstrong
(1991)
3,
237
The Champagne Route to Avermectins and Milbemycins
SV Ley, A Armstrong
– Strategies and Tactics in Organic Synthesis
(1991)
3,
237
NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES
SV LEY, AJ REDGRAVE, LL YEUNG
– ACS SYM SER
(1991)
463,
132
DIRECT SUBSTITUTION OF 2-PHENYLSULPHONYLPYRROLIDINES, 2-PHENYLSULPHONYLPIPERIDINES, 2-PHENYLSULPHONYLTETRAHYDROFURANS AND 2-PHENYLSULPHONYLTETRAHYDROPYRANS BY ALKYL ORGANOMETALLIC REAGENTS IN DICHLOROMETHANE
DS BROWN, P CHARREAU, SV LEY
– SYNLETT
(1990)
749
Direct Substitution of 2-Phenylsulphonylpyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by Alkyl Organometallic Reagents in Dichloromethane
DS Brown, P Charreau, SV Ley
– Synlett
(1990)
1990,
749
An efficient three-step synthesis of L-(-)-oleandrose from (S)-(-)-methyl lactate
MJ FORD, SV LEY
– Synlett
(1990)
1990,
771
A new ruthenium( VI ) oxidant: preparation, X -ray crystal structure, and properties of (Ph 4 P)[RuO 2 (OAc)Cl 2 ]
WP GRIFFITH, JM JOLLIFFE, SV LEY, DJ WILLIAMS
– Journal of the Chemical Society Chemical Communications
(1990)
1219
NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES
SV LEY
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1990)
200,
55
USE OF MICROBIAL OXIDANTS FOR THE PREPARATION OF INOSITOL DERIVATIVES AND RELATED CYCLITOLS
SV LEY
– ABSTR PAP AM CHEM S
(1990)
200,
123
SYNTHESIS OF BIOLOGICALLY-ACTIVE CYCLITOLS VIA MICROBIAL OXIDATION OF BENZENE
SV LEY, AJ REDGRAVE
– ABSTR PAP AM CHEM S
(1990)
200,
42
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk