Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Alkenylcyclic sulphites as novel precursors for the preparation of π-allyltricarbonyliron lactone complexes
Synlett
(1990)
1990
224
(doi: 10.1055/s-1990-21044)
Synthesis of the C12-C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)
Tetrahedron Letters
(1990)
31
5525
Enantioselective synthesis of the C3-C11 hydrocarbon fragment of the ionophore antibiotic tetronasin (ici 139603).
Tetrahedron Letters
(1990)
31
5521
SYNTHESIS OF A C16-C28 SPIROACETAL FRAGMENT OF AVERMECTIN-B1A AND REASSIGNMENT OF SOME H-1 AND C-13 RESONANCES OF AVERMECTIN-B1A
Tetrahedron Letters
(1990)
31
3445
Chemistry of insect antifeedants from azadirachta indica (part 7): Preparation of an optically pure hydroxyacetal epoxide related to azadirachtin.
Tetrahedron Letters
(1990)
31
3437
TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols
Aldrichimica Acta
(1990)
23
13
Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene
Tetrahedron
(1990)
46
4995
SYNTHESIS AND MODIFICATION OF AZADIRACHTIN AND RELATED ANTIFEEDANTS
RECENT ADVANCES IN THE CHEMISTRY OF INSECT CONTROL II
(1990)
79
90
Neo-clerodane insect antifeedants from Scutellaria galericulata
Phytochemistry
(1990)
29
1793
(doi: 10.1016/0031-9422(90)85018-b)
Chemistry of insect antifeedants from azadirachta indica (part 6): Synthesis of an optically pure acetal intermediate for potential use in the synthesis of azadirachtin and novel antifeedants.
Tetrahedron Letters
(1990)
31
431
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