Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The Champagne Route to Avermectins and Milbemycins
Strategies and Tactics in Organic Synthesis
(1991)
3
237
Chapter 7 The Champagne Route to Avermectins and Milbemycins
(1991)
3
237
NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES
INOSITOL PHOSPHATES AND DERIVATIVES
(1991)
463
132
TOTAL SYNTHESIS OF THE ANTHELMINTIC MACROLIDE AVERMECTIN B1A
J CHEM SOC PERK T 1
(1991)
667
(doi: 10.1039/p19910000667)
SYNTHESIS OF TETRAHYDROPYRAN-CONTAINING NATURAL-PRODUCTS
HETEROCYCLES IN BIO-ORGANIC CHEMISTRY
(1991)
1
An efficient three-step synthesis of L-(-)-oleandrose from (S)-(-)-methyl lactate
Synlett
(1990)
1990
771
(doi: 10.1055/s-1990-21247)
DIRECT SUBSTITUTION OF 2-PHENYLSULPHONYLPYRROLIDINES, 2-PHENYLSULPHONYLPIPERIDINES, 2-PHENYLSULPHONYLTETRAHYDROFURANS AND 2-PHENYLSULPHONYLTETRAHYDROPYRANS BY ALKYL ORGANOMETALLIC REAGENTS IN DICHLOROMETHANE
SYNLETT
(1990)
749
Direct substitution of 2-phenylsulphonylpyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by alkyl organometallic reagents in dichloromethane
Synlett
(1990)
1990
749
(doi: 10.1055/s-1990-21237)
A new ruthenium(VI) oxidant: Preparation, X-ray crystal structure, and properties of (Ph4P)[RuO2(OAc)Cl2]
Chemical Communications
(1990)
1219
(doi: 10.1039/c39900001219)
USE OF MICROBIAL OXIDANTS FOR THE PREPARATION OF INOSITOL DERIVATIVES AND RELATED CYCLITOLS
ABSTR PAP AM CHEM S
(1990)
200
123
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