Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Total synthesis of the spiroketal macrolide (+) milbemycin α1

SV LEY, A MADIN, NJT MONCK

– Tetrahedron Letters

(1993)

34,

7479

(doi: 10.1016/s0040-4039(00)60158-2)

SYNTHESIS OF 4-SUBSTITUTED IMIDAZOLES VIA 4-METALLO IMIDAZOLE INTERMEDIATES

RM TURNER, SV LEY, SD LINDELL

– Synlett

(1993)

1993,

748

(doi: 10.1055/s-1993-22594)

Microwave promoted hydrolysis of esters absorbed on alumina: A new deprotection method for pivaloyl groups

SV LEY, DM MYNETT

– Synlett

(1993)

1993,

793

(doi: 10.1055/s-1993-22612)

Dispiroketals in synthesis (part 4): Enantioselective desymmetrization of glycerol using a c2-symmetric disubstituted bis-dihydropyran.

GJ BOONS, DA ENTWISTLE, SV LEY, M WOODS

– Tetrahedron Letters

(1993)

34,

5649

(doi: 10.1016/s0040-4039(00)73906-2)

Chemistry of insect antifeedants from Azadirachta Indica (Part 15):1 Degradation studies of Azadirachtin leading to C8C14 bond cleavage.

SV LEY, PJ LOVELL, AMZ SLAWIN, SC SMITH, DJ WILLIAMS, A WOOD

– Tetrahedron

(1993)

49,

1675

(doi: 10.1016/S0040-4020(01)80354-9)

Uptake, retention, metabolism and excretion of [22,23-3H2]dihydroazadirachtin in Schistocerca gregaria

PA PARANAGAMA, H LOVELL, AA DENHOLM, SV LEY, JD CONNOLLY, RHC STRANG

– Journal of Insect Physiology

(1993)

39,

935

(doi: 10.1016/0022-1910(93)90003-a)

Some Alkylation and Reductive Amination Studies of b-Ketomacrolides as Potential Metal Speciation Materials

SV KELKAR, SV LEY

– Heterocycles

(1993)

35,

263

(doi: 10.3987/com-92-s12)

DISPIROKETALS IN SYNTHESIS .3. SELECTIVE PROTECTION OF DIEQUATORIAL VICINAL DIOLS IN CARBOHYDRATES

SV LEY, GJ BOONS, R LESLIE, M WOODS, DM HOLLINSHEAD

– Synthesis

(1993)

1993,

689

(doi: 10.1055/s-1993-25923)

Microbial Oxidation in Synthesis: Preparation of a Potential Insulin Mimic from Benzene

SV LEY, LL YEUNG

– Synlett

(1992)

1992,

997

(doi: 10.1055/s-1992-21561)

Alfred bader [2]

SV Ley

– Chemical and Engineering News

(1992)

70,

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