Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

TOTAL SYNTHESIS OF THE SPIROKETAL MACROLIDE (+) MILBEMYCIN ALPHA(1)

SV LEY, A MADIN, NJT MONCK

– Tetrahedron Letters

(1993)

34,

7479

(doi: 10.1016/S0040-4039(00)60158-2)

Microwave Promoted Hydrolysis of Esters Absorbed on Alumina: A New Deprotection Method for Pivaloyl Groups

SV LEY, DM MYNETT

– Synlett

(1993)

1993,

793

(doi: 10.1055/s-1993-22612)

SYNTHESIS OF 4-SUBSTITUTED IMIDAZOLES VIA 4-METALLO IMIDAZOLE INTERMEDIATES

RM TURNER, SV LEY, SD LINDELL

– Synlett

(1993)

1993,

748

(doi: 10.1055/s-1993-22594)

DISPIROKETALS IN SYNTHESIS .4. ENANTIOSELECTIVE DESYMMETRIZATION OF GLYCEROL USING A C2-SYMMETRICAL DISUBSTITUTED BIS-DIHYDROPYRAN

GJ BOONS, DA ENTWISTLE, SV LEY, M WOODS

– Tetrahedron Letters

(1993)

34,

5649

(doi: 10.1016/s0040-4039(00)73906-2)

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .15. DEGRADATION STUDIES OF AZADIRACHTIN LEADING TO C8-C-14 BOND-CLEAVAGE

SV LEY, PJ LOVELL, AMZ SLAWIN, SC SMITH, DJ WILLIAMS, A WOOD

– Tetrahedron

(1993)

49,

1675

(doi: 10.1016/S0040-4020(01)80354-9)

Dispiroketals in Synthesis (Part 3):1 Selective Protection of Diequatorial Vicinal Diols in Carbohydrates

SV LEY, GJ BOONS, R LESLIE, M WOODS, DM HOLLINSHEAD

– Synthesis

(1993)

1993,

689

(doi: 10.1055/s-1993-25923)

Some alkylation and reductive amination studies of β-ketomacrolides as potential metal speciation materials

SV KELKAR, SV LEY

– Heterocycles

(1993)

35,

263

(doi: 10.3987/com-92-s12)

UPTAKE, RETENTION, METABOLISM AND EXCRETION OF [22,23-H-3(2)]DIHYDROAZADIRACHTIN IN SCHISTOCERCA-GREGARIA

PA PARANAGAMA, H LOVELL, AA DENHOLM, SV LEY, JD CONNOLLY, RHC STRANG

– Journal of Insect Physiology

(1993)

39,

935

(doi: 10.1016/0022-1910(93)90003-A)

Microbial Oxidation in Synthesis: Preparation of a Potential Insulin Mimic from Benzene

SV LEY, LL YEUNG

– Synlett

(1992)

1992,

997

(doi: 10.1055/s-1992-21561)

Alfred bader [2]

SV Ley

– Chemical and Engineering News

(1992)

70,

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