Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Chemistry of insect antifeedants from Azadirachta Indica (Part 15):1 Degradation studies of Azadirachtin leading to C8C14 bond cleavage.
Tetrahedron
(1993)
49
1675
Dispiroketals in Synthesis (Part 3):1 Selective Protection of Diequatorial Vicinal Diols in Carbohydrates
Synthesis
(1993)
1993
689
(doi: 10.1055/s-1993-25923)
UPTAKE, RETENTION, METABOLISM AND EXCRETION OF [22,23-H-3(2)]DIHYDROAZADIRACHTIN IN SCHISTOCERCA-GREGARIA
Journal of Insect Physiology
(1993)
39
935
(doi: 10.1016/0022-1910(93)90003-a)
Some Alkylation and Reductive Amination Studies of b-Ketomacrolides as Potential Metal Speciation Materials
Heterocycles
(1993)
35
263
(doi: 10.3987/com-92-s12)
Microbial Oxidation in Synthesis: Preparation of a Potential Insulin Mimic from Benzene
Synlett
(1992)
1992
997
(doi: 10.1055/s-1992-21561)
Alfred bader [2]
Chemical and Engineering News
(1992)
70
2
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .12. USE OF SILICON AS A CONTROL ELEMENT IN THE SYNTHESIS OF A HIGHLY FUNCTIONALIZED DECALIN FRAGMENT OF AZADIRACHTIN
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1992)
2735
(doi: 10.1039/P19920002735)
Chemistry of insect antifeedants from Azadirachta indica, Part 14: absolute configuration of azadirachtin
Journal of the Chemical Society, Chemical Communications
(1992)
1304
(doi: 10.1039/c39920001304)
Total synthesis of the ionophore antibiotic CP-61,405 (routiennocin)
Tetrahedron
(1992)
48
7899
DISPIROKETALS IN SYNTHESIS .2. A NEW GROUP FOR THE SELECTIVE PROTECTION OF DIEQUATORIAL VICINAL DIOLS IN CARBOHYDRATES
Tetrahedron Letters
(1992)
33
4767
- ‹ previous
- Page 82
