Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Dispiroketals in synthesis (Part 11): Concomitant enantioselective and regioselective protection of 2,5- dibenzoyl-myo-inositol
– Tetrahedron Letters
(1994)
35,
7443
(doi: 10.1016/0040-4039(94)85337-1)
Chemistry of insect antifeedants from Azadirachta indica (Part 17): Synthesis of model compounds of azadirachtin. Unusual effect of remote substituents on the course of the oxidative ring contraction reaction.
– Tetrahedron
(1994)
50,
11553
SELECTIVE ACYLATION AND ALKYLATION REACTIONS OF DIOLS USING DIBUTYLTIN DIMETHOXIDE (PG 913, 1993)
– SYNLETT
(1994)
764
Chemistry of insect antifeedants from Azadirachta indica (Part 16): Synthesis of several derivatives of azadirachtin containing fluorescent or immunogenic reporter groups
– Tetrahedron
(1994)
50,
8871
Sexual development of malaria parasites is inhibited in vitro by the Neem extract Azadirachtin, and its semi-synthetic analogues
– FEMS Microbiology Letters
(1994)
120,
267
(doi: 10.1016/0378-1097(94)90482-0)
Model studies towards the insect antifeedant Jodrellin A using an organoselenium mediated cyclization reaction
– Tetrahedron Letters
(1994)
35,
4861
Dispiroketals in synthesis (part 10): Further reactions of dispoke protected lactate and glycolate enolates
– Tetrahedron
(1994)
50,
7157
Studies towards the total synthesis of rapamycin: A convergent and stereoselective synthesis of the C22C32 carbon framework
– Tetrahedron Letters
(1994)
35,
2087
STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - PREPARATION OF THE C10-C17 CARBON UNIT
– Tetrahedron Letters
(1994)
35,
2095
Studies towards the total synthesis of rapamycin: Preparation of the cyclohexyl C33C42 fragment and further coupling to afford the C22C42 carbon unit
– Tetrahedron Letters
(1994)
35,
2091
- <
- 81 of 105