Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Dispiroketals in synthesis (part 19)1: Dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols.
– Tetrahedron: Asymmetry
(1995)
6,
2403
(doi: 10.1016/0957-4166(95)00318-j)
Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination
– Synlett
(1995)
1995,
1017
(doi: 10.1055/s-1995-5164)
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN
– Synlett
(1995)
1995,
898
(doi: 10.1055/s-1995-5122)
SYNTHESIS AND CHEMISTRY OF THE INSECT ANTIFEEDANT AZADIRACHTIN
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1995)
210,
24
Regiospecific fragmentation of benzene derivatives: synthetic and analytical applications
– Tetrahedron
(1995)
51,
7755
(doi: 10.1016/0040-4020(95)00395-o)
The synthesis and assay of radiolabelled benzene derivatives
– Tetrahedron
(1995)
51,
7741
(doi: 10.1016/0040-4020(95)00394-N)
CYCLOHEXANE-1,2-DIACETALS IN SYNTHESIS .3. TUNING THE REACTIVITY OF GLYCOSIDES - EFFICIENT ONE-POT OLIGOSACCHARIDE SYNTHESIS
– SYNLETT
(1995)
781
Tuning the Reactivity of Glycosides: Efficient One-pot Oligosaccharide Synthesis1
– Synlett
(1995)
1995,
781
(doi: 10.1055/s-1995-5052)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .19. A POTENTIAL RELAY ROUTE FOR THE SYNTHESIS OF AZADIRACHTIN
– Tetrahedron
(1995)
51,
6591
(doi: 10.1016/0040-4020(95)00297-L)
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