Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds
Journal of Organic Chemistry
(2002)
56
5739
(doi: 10.1021/jo00020a002)
Total synthesis of the ionophore antibiotic X-14547A (Indanomycin)
Journal of Organic Chemistry
(2002)
49
3503
(doi: 10.1021/jo00193a014)
Synthesis and Reducibility of Homo-2-methoxyazocines and Their Benzo-Fused Derivatives. An Examination of Heteroatomic Influences on the Possible Generation of 9C-10π Homoaromatic Dianions
Journal of Organic Chemistry
(2002)
43
4712
(doi: 10.1021/jo00419a007)
Encapsulation of palladium in polyurea microcapsules
Chem Commun (Camb)
(2002)
10
1132
(doi: 10.1039/b200674j)
Polyurea-encapsulated palladium(II) acetate: A robust and recyclable catalyst for use in conventional and supercritical media
Chemical communications (Cambridge, England)
(2002)
2
1134
(doi: 10.1039/b200677b)
Analytical construct resins for analysis of solid-phase chemistry.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8
The total synthesis of the annonaceous acetogenin, muricatetrocin C.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8
Solid-supported reagents for multi-step organic synthesis: preparation and application
Farmaco (Societa chimica italiana : 1989)
(2002)
57
321
The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C
Chemistry
(2002)
8
1621
Analytical construct resins for analysis of solid-phase chemistry
Chemistry A European Journal
(2002)
8
1768
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