Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
1,5-Asymmetric induction of chirality using pi-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of alpha-functionalised carbonyl compounds
– Organic & Biomolecular Chemistry
(2003)
1,
3208
(doi: 10.1039/b306862e)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
– Chemical Communications
(2003)
3,
468
(doi: 10.1039/b210673f)
Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase β and HIV reverse transcriptase
– Org. Biomol. Chem.
(2003)
1,
1664
(doi: 10.1039/b301676p)
Synthesis of Enantiomers ofButane-1,2-diacetal-Protected Glyceraldehyde and of (R,R)-Butane-1,2-diacetal-ProtectedGlycolic Acid
– Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors (vol 1, pg 2419, 2003)
– ORGANIC & BIOMOLECULAR CHEMISTRY
(2003)
1,
2807
(doi: 10.1039/b305713e)
Reductive decomplexation of pi-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-1,7-diols
– Organic & Biomolecular Chemistry
(2003)
1,
3197
(doi: 10.1039/b306861g)
Development of new synthetic tools for the preparation of biologically active molecules
– CHEMICAL PROBES IN BIOLOGY: SCIENCE AT THE INTERFACE OF CHEMISTRY, BIOLOGY AND MEDICINE
(2003)
129,
235
Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis
– Organic & Biomolecular Chemistry
(2003)
1,
15
(doi: 10.1039/b208982c)
A rapid stereocontrolled synthesis of the 3 a -hydroxy-pyrrolo[2,3- b ]indole skeleton, a building block for 10 b -hydroxy-pyrazino[1′,2′:1,5]pyrrolo[2,3- b ]indole-1,4-diones
– Organic & Biomolecular Chemistry
(2003)
1,
3492
(doi: 10.1039/b308288a)
Copper(I)-catalyzed preparation of (E)-3-iodoprop-2-enoic acid: [(2-propenoic acid, 3-iodo-, (2E)-)]
– Organic Syntheses
(2003)
80,
129
(doi: 10.15227/orgsyn.080.0129)
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