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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Development of an organocatalytic intramolecular cyclopropanation reaction.
N Bremeyer, MWJ Gaunt, SV Ley
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U341
Development of an organic-catalyst mediated cyclopropanation reaction
MJ Gaunt, SV Ley, C Papageorgiou, N Bremeyer
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U361
Development of new methods suitable for natural product synthesis
SV Ley
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U312
Studies toward the total synthesis of 10-hydroxyasimicin.
SV Ley, DJ Dixon, GL Nattrass, E Diez-Martin
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U349
Organic-catalyst-mediated cyclopropanation reaction
CD Papageorgiou, SV Ley, MJ Gaunt
– Angew Chem Int Ed Engl
(2003)
42,
828
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
J-Q Yu, H-C Wu, C Ramarao, JB Spencer, SV Ley
– Chem Commun (Camb)
(2003)
3,
678
A 2,3-butanedione protected chiral glycine equivalent - a new building block for the stereoselective synthesis of enantiopure N-protected alpha-amino acids
DJ Dixon, CI Harding, SV Ley, DMG Tilbrook
– Chemical communications (Cambridge, England)
(2003)
468
Development of new synthetic tools for the preparation of biologically active molecules
SV Ley, IR Baxendale, P Grice
– CHEMICAL PROBES IN BIOLOGY: SCIENCE AT THE INTERFACE OF CHEMISTRY, BIOLOGY AND MEDICINE
(2003)
129,
235
Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis
MJ Gaunt, HF Sneddon, PR Hewitt, P Orsini, DF Hook, SV Ley
– Org Biomol Chem
(2003)
1,
15
Synthesis of (-)-Gloeosporone, a fungal autoinhibitor of spore germination using a pi-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction
SV Ley, E Cleator, J Harter, CJ Hollowood
– Organic & Biomolecular Chemistry
(2003)
1,
3263
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk