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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Development of new methods suitable for natural product synthesis
SV Ley
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U312
Studies toward the total synthesis of 10-hydroxyasimicin.
SV Ley, DJ Dixon, GL Nattrass, E Diez-Martin
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U349
Development of an organocatalytic intramolecular cyclopropanation reaction.
N Bremeyer, MWJ Gaunt, SV Ley
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U341
Organic-catalyst-mediated cyclopropanation reaction
CD Papageorgiou, SV Ley, MJ Gaunt
– Angewandte Chemie (International ed. in English)
(2003)
42,
828
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
J-Q Yu, H-C Wu, C Ramarao, JB Spencer, SV Ley
– Chemical Communications
(2003)
3,
678
A 2,3-butanedione protected chiral glycine equivalent - a new building block for the stereoselective synthesis of enantiopure N-protected alpha-amino acids
DJ Dixon, CI Harding, SV Ley, DMG Tilbrook
– Chemical Communications
(2003)
468
Total synthesis of the phytotoxic agent herbarumin II using butane diacetals of glycolic acid as building blocks
E Diez, DJ Dixon, SV Ley, A Polara, F Rodriguez
– Synlett
(2003)
1186
Supported Reagents and Scavengers in Multi-Step Organic Synthesis
IR Baxendale, SV Ley
(2003)
53
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
JQ Yu, HC Wu, C Ramarao, JB Spencer, SV Ley
– Chemical communications (Cambridge, England)
(2003)
678
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
EP Balskus, SV Ley
– Chemtracts
(2003)
16,
443
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk