Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total Synthesis of the PhytotoxicAgent Herbarumin II Using Butane Diacetals of Glycolic Acid as BuildingBlocks
Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
Synthesis of Enantiomers ofButane-1,2-diacetal-Protected Glyceraldehyde and of ( R , R )-Butane-1,2-diacetal-ProtectedGlycolic Acid
Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Development of new synthetic tools for the preparation of biologically active molecules
CHEMICAL PROBES IN BIOLOGY: SCIENCE AT THE INTERFACE OF CHEMISTRY, BIOLOGY AND MEDICINE
(2003)
129
235
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
Chemtracts
(2003)
16
443
COPPER(I)-CATALYZED PREPARATION OF (E)-3-IODOPROP-2-ENOIC ACID
Organic Syntheses
(2003)
80
129
(doi: 10.15227/orgsyn.080.0129)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
Chemical communications (Cambridge, England)
(2003)
678
Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis
Org. Biomol. Chem.
(2003)
1
15
(doi: 10.1039/b208982c)
Analytical techniques for small molecule solid phase synthesis.
Current Medicinal Chemistry
(2002)
9
2103
(doi: 10.2174/0929867023368737)
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