Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Organic‐Catalyst‐Mediated Cyclopropanation Reaction
Angewandte Chemie International Edition
(2003)
42
828
(doi: 10.1002/anie.200390222)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: Efficient and chemoselective reduction of aryl ketones
Chem Commun (Camb)
(2003)
3
678
(doi: 10.1039/b300074p)
Reductive decomplexation of π-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-1,7-diols
Organic & Biomolecular Chemistry
(2003)
1
3197
(doi: 10.1039/b306861g)
Total synthesis of the phytotoxic agent herbarumin II using butane diacetals of glycolic acid as building blocks
Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
Synthesis of Enantiomers ofButane-1,2-diacetal-Protected Glyceraldehyde and of ( R , R )-Butane-1,2-diacetal-ProtectedGlycolic Acid
Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
Chemical communications (Cambridge, England)
(2003)
678
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
Chemtracts
(2003)
16
443
COPPER(I)-CATALYZED PREPARATION OF (E)-3-IODOPROP-2-ENOIC ACID
Organic Syntheses
(2003)
80
129
(doi: 10.15227/orgsyn.080.0129)
Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis
Org. Biomol. Chem.
(2003)
1
15
(doi: 10.1039/b208982c)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
Chemical Communications
(2003)
3
468
(doi: 10.1039/b210673f)
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