Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.
– Chem Commun (Camb)
(2006)
4835
(doi: 10.1039/b612197g)
Sulphuration of Electron-Rich Arenes with Sulphenamides and Aminosulphenyl Chlorides
– Synthetic Communications
(2006)
10,
291
(doi: 10.1080/00397918008062752)
Polymer-supported reagents and scavengers in synthesis
(2006)
3,
791
Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.
– Organic letters
(2006)
8,
5231
(doi: 10.1021/ol061975c)
Stereocontrolled total synthesis of bengazole A: A marine bisoxazole natural product displaying potent antifungal properties
– Angew Chem Int Ed Engl
(2006)
45,
6714
(doi: 10.1002/anie.200602050)
An enantioselective organocatalytic route to chiral 3,6-dihydropyridazines from aldehydes
– Synlett
(2006)
2006,
2548
(doi: 10.1055/s-2006-951486)
ORGN 141-Asymmetric organocatalytic conjugate addition of malonates to enones using a proline tetrazole catalyst
– ABSTR PAP AM CHEM S
(2006)
232,
Enantioselective catalytic intramolecular cyclopropanation using modified cinchona alkaloid organocatalysts
– Angew Chem Int Ed Engl
(2006)
45,
6024
(doi: 10.1002/anie.200602129)
8,9,10,10a-Tetrahydro-6 H -tetrazolo[1,5- a ]pyrrolo[2,1- c ]pyrazines: New Heterocyclic Frameworks Generated by an Ugi-Type Multicomponent Reaction
– Synthesis
(2006)
2006,
3215
(doi: 10.1055/s-2006-950219)
Hydrogenation of aromatic ketones, aldehydes, and epoxides with hydrogen and Pd(0)EnCat (TM) 30NP
– Beilstein J Org Chem
(2006)
2,
15
(doi: 10.1186/1860-5397-2-15)
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