Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Targeting C-reactive protein for the treatment of cardiovascular disease.

MB Pepys, GM Hirschfield, GA Tennent, JR Gallimore, MC Kahan, V Bellotti, PN Hawkins, RM Myers, MD Smith, A Polara, AJA Cobb, SV Ley, JA Aquilina, CV Robinson, I Sharif, GA Gray, CA Sabin, MC Jenvey, SE Kolstoe, D Thompson, SP Wood

Nature

(2006)

440

1217

(doi: 10.1038/nature04672)

Chemical variation of natural product-like scaffolds: Design and synthesis of spiroketal derivatives

G Zinzalla, L-G Milroy, SV Ley

Organic and Biomolecular Chemistry

(2006)

1977

(doi: 10.1039/b603015g)

An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones

CET Mitchell, SE Brenner, J García-Fortanet, SV Ley

Organic & biomolecular chemistry

(2006)

2039

(doi: 10.1039/b601877g)

A highly enantioselective total synthesis of (+)-goniodiol.

EW Tate, DJ Dixon, SV Ley

Org Biomol Chem

(2006)

1698

(doi: 10.1039/b602805e)

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

IR Baxendale, J Deeley, CM Griffiths-Jones, SV Ley, S Saaby, GK Tranmer

Chemical communications (Cambridge, England)

(2006)

2566

(doi: 10.1039/b600382f)

Practical Synthesis of ( S )-Pyrrolidin-2-yl-1 H -tetrazole, Incorporating Efficient Protecting Group Removal by Flow-Reactor Hydrogenolysis

S Ley, V Franckevičius, K Knudsen, M Ladlow, D Longbottom

Synlett

(2006)

2006

889

(doi: 10.1055/s-2006-939036)

Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives.

KR Knudsen, AF Stepan, P Michel, SV Ley

Organic & Biomolecular Chemistry

(2006)

1471

(doi: 10.1039/b601888b)

Double Conjugate Addition of Dithiols to Propargylic Carbonyl Systems To Generate Protected 1,3-Dicarbonyl Compounds

HF Sneddon, A van den Heuvel, AKH Hirsch, RA Booth, DM Shaw, MJ Gaunt, SV Ley

The Journal of organic chemistry

(2006)

2715

(doi: 10.1021/jo052514s)

Preparation of the neolignan natural product grossamide by a continuous-flow process

S Ley, I Baxendale, C Griffiths-Jones, G Tranmer

Synlett

(2006)

2006

427

(doi: 10.1055/S-2006-926244)

A New Strategy for Oligosaccharide Assembly Exploiting Cyclohexane‐1,2‐diacetal Methodology: An Efficient Synthesis of a High Mannose Type Nonasaccharide

P Grice, SV Ley, J Pietruszka, HMI Osborn, HWM Priepke, SL Warriner

Chemistry A European Journal

(2006)

431

(doi: 10.1002/chem.19970030315)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Group

Research Interest Groups

Telephone number

Email address

College

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge