University Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Structure and Properties of DNA in Apolar Solvents
J Phys Chem B
(2014)
118
8540
(doi: 10.1021/jp503816r)
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure
Nucleic Acids Res
(2014)
42
7553
(doi: 10.1093/nar/gku491)
Chromatin fiber polymorphism triggered by variations of DNA linker lengths.
Proc Natl Acad Sci U S A
(2014)
111
8061
(doi: 10.1073/pnas.1315872111)
Insights into chromatin architecture by mesoscale modeling of oligonucleosomes
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
246
NAFlex: a web server for the study of nucleic acid flexibility.
Nucleic Acids Research
(2013)
41
w47
(doi: 10.1093/nar/gkt378)
Insights into chromatin fibre structure by in vitro and in silico single-molecule stretching experiments
Biochemical Society Transactions
(2013)
41
494
(doi: 10.1042/BST20120349)
Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes
Nucleic acids research
(2012)
40
8803
(doi: 10.1093/nar/gks600)
The effect of linker histone's nucleosome binding affinity on chromatin unfolding mechanisms.
Biophysical Journal
(2011)
101
1670
(doi: 10.1016/j.bpj.2011.07.044)
Bimolecular reaction rates from ring polymer molecular dynamics: application to H + CH4 → H2 + CH3.
The Journal of Chemical Physics
(2011)
134
044131
(doi: 10.1063/1.3533275)
Biomolecular modeling and simulation: a field coming of age
Quarterly Reviews of Biophysics
(2011)
44
191
(doi: 10.1017/S0033583510000284)
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