University Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1
Nucleic Acids Res
(2020)
48
5318
(doi: 10.1093/NAR/GKAA285)
Surface electrostatics govern the emulsion stability of biomolecular condensates
(2020)
2020.04.20.047910
(doi: 10.1101/2020.04.20.047910)
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
7216
(doi: 10.1073/pnas.1910044117)
Phosphorylation of Intrinsically Disordered Regions within the Genome
BIOPHYSICAL JOURNAL
(2020)
118
296A
Oligonucleotides can act as superscaffolds that enhance liquid-liquid phase separation of intracellular mixtures
(2020)
2020.01.24.916858
(doi: 10.1101/2020.01.24.916858)
Breakdown of the law of rectilinear diameter and related surprises in the liquid-vapor coexistence in systems of patchy particles
The Journal of chemical physics
(2019)
150
224510
(doi: 10.1063/1.5098551)
Chromatin Structure Regulation by an Epigenetic Switch Tuning the Flexibility of the H1 C-Terminal Domain
Biophysical Journal
(2019)
116
70A
(doi: 10.1016/j.bpj.2018.11.420)
Chromatin unfolding by epigenetic modifications explained by dramatic impairment of internucleosome interactions: A multiscale computational study
J Am Chem Soc
(2015)
137
10205
(doi: 10.1021/jacs.5b04086)
Forced unraveling of chromatin fibers with nonuniform linker DNA lengths.
Journal of Physics: Condensed Matter
(2015)
27
064113
Energy Landscapes, Folding Mechanisms, and Kinetics of RNA Tetra loop Hairpins
J Am Chem Soc
(2014)
136
18052
(doi: 10.1021/ja5100756)
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