skip to content

Department of Chemistry

 

Publications

Efficient development of stable and highly functionalised peptides targeting the CK2 alpha/CK2 beta protein-protein interaction
J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O' Donovan, CS Verma, M Hyvönen, DR Spring
– Chemical Science
(2019)
10,
5056
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
J Charoenpattarapreeda, YS Tan, J Iegre, SJ Walsh, E Fowler, RS Eapen, Y Wu, HF Sore, CS Verma, L Itzhaki, DR Spring
– Chemical communications (Cambridge, England)
(2019)
55,
7914
Two-component stapling of biologically active and conformationally constrained peptides: past, present and future
J Iegre, JS Gaynord, NS Robertson, HF Sore, M Hyvönen, DR Spring
– Advanced Therapeutics
(2018)
1,
1800052
Novel non-ATP competitive small molecules targeting the CK2 α/β interface
P Brear, A North, J Iegre, K Hadje Georgiou, A Lubin, L Carro, W Green, HF Sore, M Hyvönen, DR Spring
– Bioorg Med Chem
(2018)
26,
3016
Stapled peptides as a new technology to investigate protein-protein interactions in human platelets
J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ME Lopes-Pires, R Jha, YH Lau, HF Sore, C Verma, DH O' Donovan, N Pugh, DR Spring
– Chemical science
(2018)
9,
4638
Second-generation CK2 alpha inhibitors targeting the alpha D pocket
J Iegre, P Brear, C De Fusco, M Yoshida, SL Mitchell, M Rossmann, L Carro, HF Sore, M Hyvönen, DR Spring
– Chemical Science
(2018)
9,
3041
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
– Bioorg Med Chem
(2017)
25,
3471
Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data.
J Iegre, MA Hayes, RA Thompson, L Weidolf, EM Isin
– Drug Metab Dispos
(2016)
44,
732
Binding Mode and Induced Fit Predictions for Prospective Computational Drug Design
C Grebner, J Iegre, J Ulander, K Edman, A Hogner, C Tyrchan
– Journal of Chemical Information and Modeling
(2016)
56,
774
Salicylketoximes That Target Glucose Transporter1 Restrict Energy Supply to Lung Cancer Cells
C Granchi, Y Qian, HY Lee, I Paterni, C Pasero, J Iegre, KE Carlson, T Tuccinardi, X Chen, JA Katzenellenbogen, PJ Hergenrother, F Minutolo
– ChemMedChem
(2015)
10,
1892
  • 1 of 2
  • >

Research Group

Email address

ji243@cam.ac.uk