Research Associate

Publications

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction
J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O' Donovan, CS Verma, M Hyvönen, DR Spring
Chem Sci
(2019)
10
Two‐Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future
J Iegre, JS Gaynord, NS Robertson, HF Sore, M Hyvönen, DR Spring
Advanced Therapeutics
(2018)
1
Novel non-ATP competitive small molecules targeting the CK2 α/β interface
P Brear, AJP North, J Iegre, K Hadje Georgiou, A Lubin, L Carro, W Green, H Sore, M Hyvonen, D Spring
Bioorganic & Medicinal Chemistry
(2018)
26
Stapled peptides as a new technology to investigate protein–protein interactions in human platelets
J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ME Lopes-Pires, R Jha, YH Lau, HF Sore, C Verma, DH O' Donovan, N Pugh, DR Spring
Chem Sci
(2018)
9
Second-generation CK2α inhibitors targeting the αD pocket.
J Iegre, P Brear, C De Fusco, M Yoshida, SL Mitchell, M Rossmann, L Carro, HF Sore, M Hyvönen, DR Spring
Chemical science
(2018)
9
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
Bioorganic & Medicinal Chemistry
(2017)
25
Binding Mode and Induced Fit Predictions for Prospective Computational Drug Design
C Grebner, J Iegre, J Ulander, K Edman, A Hogner, C Tyrchan
Journal of Chemical Information and Modeling
(2016)
56
Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data
J Iegre, MA Hayes, RA Thompson, L Weidolf, EM Isin
Drug Metabolism and Disposition
(2016)
44
Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells.
C Granchi, Y Qian, HY Lee, I Paterni, C Pasero, J Iegre, KE Carlson, T Tuccinardi, X Chen, JA Katzenellenbogen, PJ Hergenrother, F Minutolo
ChemMedChem
(2015)
10
Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells
T Tuccinardi, C Granchi, J Iegre, I Paterni, S Bertini, M Macchia, A Martinelli, Y Qian, X Chen, F Minutolo
Bioorganic & Medicinal Chemistry Letters
(2013)
23

Research Group

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