Yusuf Hamied Department of Chemistry

Professor Jason Chin FMedSci FRS

Professor of Chemistry & Chemical Biology

Publications

Escherichia coli with a 57-codon genetic code
WE Robertson, FBH Rehm, M Spinck, RL Schumann, R Tian, W Liu, Y Gu, AA Kleefeldt, CF Day, KC Liu, Y Christova, JF Zürcher, FL Böge, J Birnbaum, L van Bijsterveldt, JW Chin
Science
(2025)
390
(doi: 10.1126/science.ady4368)
Genetic Code-Locking Confers Stable Virus Resistance to a Recoded Organism.
JF Zürcher, A Dickson, T Kappes, AA Kleefeldt, KC Liu, GPC Salmond, JW Chin
Biochemistry
(2025)
64
(doi: 10.1021/acs.biochem.5c00075)
Escherichia coli with a 57-codon genetic code
WE Robertson, FBH Rehm, M Spinck, RL Schumann, R Tian, W Liu, Y Gu, AA Kleefeldt, CF Day, KC Liu, Y Christova, JF Zürcher, FL Böge, J Birnbaum, L van Bijsterveldt, JW Chin
(2025)
(doi: 10.1101/2025.05.02.651837)
Automated orthogonal tRNA generation.
M Spinck, A Guppy, JW Chin
Nat Chem Biol
(2024)
21
(doi: 10.1038/s41589-024-01782-3)
Correction to: Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS (Nature Protocols, (2021), 16, 5, (2345-2380), 10.1038/s41596-020-00464-3)
WE Robertson, LFH Funke, D de la Torre, J Fredens, K Wang, JW Chin
Nat Protoc
(2024)
(doi: 10.1038/s41596-024-01114-8)
Engineering Pyrrolysine Systems for Genetic Code Expansion and Reprogramming
DL Dunkelmann, JW Chin
Chemical reviews
(2024)
124
(doi: 10.1021/acs.chemrev.4c00243)
Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification
J Luo, Y Yu, K Wang, S He, L Wang, F Liang, JW Chin, S Tang
Nature Protocols
(2024)
19
(doi: 10.1038/s41596-024-01006-x)
Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli
R Tian, FBH Rehm, D Czernecki, Y Gu, JF Zürcher, KC Liu, JW Chin
Science (New York, N.Y.)
(2024)
383
(doi: 10.1126/science.adk1281)
Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism.
DL Dunkelmann, C Piedrafita, A Dickson, KC Liu, TS Elliott, M Fiedler, D Bellini, A Zhou, D Cervettini, JW Chin
Nature
(2024)
625
(doi: 10.1038/s41586-023-06897-6)
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
JF Zürcher, AA Kleefeldt, LFH Funke, J Birnbaum, J Fredens, S Grazioli, KC Liu, M Spinck, G Petris, P Murat, FBH Rehm, JE Sale, JW Chin
Nature
(2023)
619
(doi: 10.1038/s41586-023-06268-1)

Research Group

Research Interest Group

Email address

chin@mrc-lmb.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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