Professor of Chemistry & Chemical Biology
Publications
Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli.
– Science
(2024)
383,
421
(doi: 10.1126/science.adk1281)
Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism.
– Nature
(2024)
625,
603
(doi: 10.1038/s41586-023-06897-6)
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
– Nature
(2023)
619,
555
(doi: 10.1038/s41586-023-06268-1)
Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNAPyl pairs
– Nature Chemistry
(2023)
15,
948
(doi: 10.1038/s41557-023-01232-y)
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles
– Nat Chem
(2022)
15,
61
(doi: 10.1038/s41557-022-01082-0)
Refactored genetic codes enable bidirectional genetic isolation
– Science (New York, N.Y.)
(2022)
378,
516
(doi: 10.1126/science.add8943)
RBBP6 activates the pre-mRNA 3' end processing machinery in humans
– Genes Dev
(2022)
36,
210
(doi: 10.1101/gad.349223.121)
Mechanism-based traps enable protease and hydrolase substrate discovery
– Nature
(2022)
602,
701
(doi: 10.1038/s41586-022-04414-9)
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons.
– Proceedings of the National Academy of Sciences of the United States of America
(2022)
119,
e2113845119
(doi: 10.1073/pnas.2113845119)
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites.
– Molecular cell
(2021)
81,
4891
(doi: 10.1016/j.molcel.2021.10.011)
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