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Yusuf Hamied Department of Chemistry

 

Professor of Chemistry & Chemical Biology

Publications

Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
JF Zürcher, AA Kleefeldt, LFH Funke, J Birnbaum, J Fredens, S Grazioli, KC Liu, M Spinck, G Petris, P Murat, FBH Rehm, JE Sale, JW Chin
– Nature
(2023)
619,
555
Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNAPyl pairs.
AT Beattie, DL Dunkelmann, JW Chin
– Nature chemistry
(2023)
15,
948
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles.
M Spinck, C Piedrafita, WE Robertson, TS Elliott, D Cervettini, D de la Torre, JW Chin
– Nature chemistry
(2022)
15,
61
Refactored genetic codes enable bidirectional genetic isolation.
JF Zürcher, WE Robertson, T Kappes, G Petris, TS Elliott, GPC Salmond, JW Chin
– Science (New York, N.Y.)
(2022)
378,
516
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans
V Boreikaite, TS Elliott, JW Chin, LA Passmore
– Genes Dev
(2022)
36,
210
Mechanism-based traps enable protease and hydrolase substrate discovery
S Tang, AT Beattie, L Kafkova, G Petris, N Huguenin-Dezot, M Fiedler, M Freeman, JW Chin
– Nature
(2022)
602,
701
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons
NJ Smyllie, J Bagnall, AA Koch, D Niranjan, L Polidarova, JE Chesham, JW Chin, CL Partch, ASI Loudon, MH Hastings
– Proceedings of the National Academy of Sciences
(2022)
119,
e2113845119
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites
F Bürmann, LFH Funke, JW Chin, J Löwe
– Mol Cell
(2021)
81,
4891
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design
DL Dunkelmann, SB Oehm, AT Beattie, JW Chin
– Nat Chem
(2021)
13,
1110
Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase.
L Davis, I Radman, A Goutou, A Tynan, K Baxter, Z Xi, JM O'Shea, JW Chin, S Greiss
– eLife
(2021)
10,
e67075
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Research Group

Research Interest Group

Email address

chin@mrc-lmb.cam.ac.uk