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Department of Chemistry

 
Portrait of jc482

Publications

Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly.
K Wang, D de la Torre, WE Robertson, JW Chin
– Science
(2019)
365,
922
Efficient Phage Display with Multiple Distinct Non-Canonical Amino Acids Using Orthogonal Ribosome-Mediated Genetic Code Expansion.
B Oller-Salvia, JW Chin
– Angew Chem Int Ed Engl
(2019)
58,
10844
Total synthesis of Escherichia coli with a recoded genome.
J Fredens, K Wang, D de la Torre, LFH Funke, WE Robertson, Y Christova, T Chia, WH Schmied, DL Dunkelmann, V Beránek, C Uttamapinant, AG Llamazares, TS Elliott, JW Chin
– Nature
(2019)
569,
514
The Genetic Code is Read by an Idiosyncratic and Highly-Connected Decoding Network
SD Fried, TS Elliott, M Wagner, T Carell, JW Chin
– Biophysical Journal
(2019)
116,
360A
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid
N Huguenin-Dezot, DA Alonzo, GW Heberlig, M Mahesh, DP Nguyen, MH Dornan, CN Boddy, TM Schmeing, JW Chin
– Nature
(2019)
565,
112
Controlling orthogonal ribosome subunit interactions enables evolution of new function
WH Schmied, Z Tnimov, C Uttamapinant, CD Rae, SD Fried, JW Chin
– Nature
(2018)
564,
444
Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice.
ES Maywood, TS Elliott, AP Patton, TP Krogager, JE Chesham, RJ Ernst, V Beránek, M Brancaccio, JW Chin, MH Hastings
– Proc Natl Acad Sci U S A
(2018)
115,
E12388
Correction to: Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins (Journal of the American Chemical Society (2015): 137: (4602-4605): DOI: 10.1021/ja512838z)
C Uttamapinant, JD Howe, K Lang, V Beránek, L Davis, M Mahesh, NP Barry, JW Chin
– J Am Chem Soc
(2018)
140,
13986
An Evolved Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase/tRNA Pair Is Highly Active and Orthogonal in Mammalian Cells
V Beránek, JCW Willis, JW Chin
– Biochemistry
(2019)
58,
387
A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation
M Baumdick, M Gelléri, C Uttamapinant, V Beránek, JW Chin, PIH Bastiaens
– Nat Commun
(2018)
9,
3847
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Research Group

Research Interest Group

Email address

chin@mrc-lmb.cam.ac.uk