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Department of Chemistry

 
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Publications

Engineered triply orthogonal pyrrolysyl–tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids
DL Dunkelmann, JCW Willis, AT Beattie, JW Chin
– Nat Chem
(2020)
12,
535
Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase-tRNA pairs.
D Cervettini, S Tang, SD Fried, JCW Willis, LFH Funke, LJ Colwell, JW Chin
– Nat Biotechnol
(2020)
38,
989
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.
MR Hodskinson, A Bolner, K Sato, AN Kamimae-Lanning, K Rooijers, M Witte, M Mahesh, J Silhan, M Petek, DM Williams, J Kind, JW Chin, KJ Patel, P Knipscheer
– Nature
(2020)
579,
603
Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly.
K Wang, D de la Torre, WE Robertson, JW Chin
– Science (New York, N.Y.)
(2019)
365,
922
Efficient Phage Display with Multiple Distinct Non‐Canonical Amino Acids Using Orthogonal Ribosome‐Mediated Genetic Code Expansion
B Oller-Salvia, JW Chin
– Angew Chem Int Ed Engl
(2019)
58,
10844
Total synthesis of Escherichia coli with a recoded genome.
J Fredens, K Wang, D de la Torre, LFH Funke, WE Robertson, Y Christova, T Chia, WH Schmied, DL Dunkelmann, V Beránek, C Uttamapinant, AG Llamazares, TS Elliott, JW Chin
– Nature
(2019)
569,
514
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.
N Huguenin-Dezot, DA Alonzo, GW Heberlig, M Mahesh, DP Nguyen, MH Dornan, CN Boddy, TM Schmeing, JW Chin
– Nature
(2019)
565,
112
Controlling orthogonal ribosome subunit interactions enables evolution of new function
WH Schmied, Z Tnimov, C Uttamapinant, CD Rae, SD Fried, JW Chin
– Nature
(2018)
564,
444
Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice
ES Maywood, TS Elliott, AP Patton, TP Krogager, JE Chesham, RJ Ernst, V Beránek, M Brancaccio, JW Chin, MH Hastings
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
201811438
Correction to “Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins”
C Uttamapinant, JD Howe, K Lang, V Beránek, L Davis, M Mahesh, NP Barry, JW Chin
– J Am Chem Soc
(2018)
140,
13986
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Research Group

Research Interest Group

Email address

chin@mrc-lmb.cam.ac.uk