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Yusuf Hamied Department of Chemistry

 

Professor of Chemistry & Chemical Biology

Publications

Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli.
R Tian, FBH Rehm, D Czernecki, Y Gu, JF Zürcher, KC Liu, JW Chin
– Science
(2024)
383,
421
Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism
DL Dunkelmann, C Piedrafita, A Dickson, KC Liu, TS Elliott, M Fiedler, D Bellini, A Zhou, D Cervettini, JW Chin
– Nature
(2024)
625,
603
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
JF Zürcher, AA Kleefeldt, LFH Funke, J Birnbaum, J Fredens, S Grazioli, KC Liu, M Spinck, G Petris, P Murat, FBH Rehm, JE Sale, JW Chin
– Nature
(2023)
619,
555
Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNAPyl pairs.
AT Beattie, DL Dunkelmann, JW Chin
– Nat Chem
(2023)
15,
948
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles.
M Spinck, C Piedrafita, WE Robertson, TS Elliott, D Cervettini, D de la Torre, JW Chin
– Nature Chemistry
(2022)
15,
61
Refactored genetic codes enable bidirectional genetic isolation
JF Zürcher, WE Robertson, T Kappes, G Petris, TS Elliott, GPC Salmond, JW Chin
– Science
(2022)
378,
516
RBBP6 activates the pre-mRNA 3' end processing machinery in humans
V Boreikaite, TS Elliott, JW Chin, LA Passmore
– Genes and Development
(2022)
36,
210
Mechanism-based traps enable protease and hydrolase substrate discovery.
S Tang, AT Beattie, L Kafkova, G Petris, N Huguenin-Dezot, M Fiedler, M Freeman, JW Chin
– Nature
(2022)
602,
701
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons
NJ Smyllie, J Bagnall, AA Koch, D Niranjan, L Polidarova, JE Chesham, JW Chin, CL Partch, ASI Loudon, MH Hastings
– Proceedings of the National Academy of Sciences
(2022)
119,
e2113845119
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites.
F Bürmann, LFH Funke, JW Chin, J Löwe
– Molecular Cell
(2021)
81,
4891
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Research Group

Research Interest Group

Email address

chin@mrc-lmb.cam.ac.uk