Professor David Spring | Page 19 | Yusuf Hamied Department of Chemistry

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Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.

A Chattopadhyay, CJ O'Connor, F Zhang, C Galvagnion, WRJD Galloway, YS Tan, JE Stokes, T Rahman, C Verma, DR Spring, LS Itzhaki

– Scientific reports

(2016)

6,

23732

(doi: 10.1038/srep23732)

Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology

S Collins, S Bartlett, F Nie, HF Sore, DR Spring

– Synthesis

(2016)

48,

1457

(doi: 10.1055/s-0035-1561414)

Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling

Y Wu, LB Olsen, YH Lau, CH Jensen, M Rossmann, YR Baker, HF Sore, S Collins, DR Spring

– ChemBioChem

(2016)

17,

689

(doi: 10.1002/cbic.201500648)

Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu

TJ Sum, TH Sum, WRJD Galloway, DR Spring

– Synlett

(2016)

27,

1725

(doi: 10.1055/s-0035-1561851)

Structure of the Stapled Peptide Bound to Mdm2

YH Lau, Y Wu, M Rossmann, P de Andrade, YS Tan, GJ McKenzie, AR Venkitaraman, M Hyvonen, DR Spring

(2016)

(doi: 10.2210/pdb5afg/pdb)

A new <i>Pseudomonas</i> quinolone signal (PQS) binding partner: MexG.

JT Hodgkinson, J Gross, YR Baker, DR Spring, M Welch

– Chem Sci

(2016)

7,

2553

(doi: 10.1039/c5sc04197j)

Divergent synthesis of six biologically active 4-quinolone natural products isolated from Pseudonocardia sp CL38489

S Geddis, D Spring

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2016)

252,

(link to publication)

NEW ADVANCES IN DIVERSITY-ORIENTED SYNTHESIS

WRJD Galloway, JE Stokes, DR Spring

(2016)

79

(link to publication)

Synthesis of diverse semi-saturated bicyclic heteroaromatics

H Stewart, D Spring, T Moss

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2016)

252,

(link to publication)

Targeting transcription factor HNF1β in ovarian cancer using stapled peptides

M Wiedmann, D Spring, J Brenton

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2016)

251,

(link to publication)