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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(doi: 10.2210/pdb5dt4/pdb)
Aurora A in complex with ATP and AA35.
M Janecek, M Rossmann, P Sharma, A Emery, G McKenzie, D Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, A Venkitaraman
(2016)
(doi: 10.2210/pdb5dn3/pdb)
Specific inhibition of CK2α from an anchor outside the active site
P Brear, C De Fusco, K Hadje Georgiou, NJ Francis-Newton, CJ Stubbs, HF Sore, AR Venkitaraman, C Abell, DR Spring, M Hyvönen
– Chemical Science
(2016)
7,
6839
(doi: 10.1039/c6sc02335e)
Multiple‐parameter Optimization in Drug Discovery: Example of the 5‐HT1B GPCR
RC Glen, WRJD Galloway, DR Spring, G Liwiki
– Molecular Informatics
(2016)
35,
599
(doi: 10.1002/minf.201600056)
Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells
B Morkunas, B Gal, WRJD Galloway, JT Hodgkinson, BM Ibbeson, YS Tan, M Welch, DR Spring
– Beilstein J Org Chem
(2016)
12,
1228
(doi: 10.3762/bjoc.12.137)
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5
W Xu, G Fischer, M Hyvonen, L Itzhaki
(2016)
(doi: 10.2210/pdb5bxu/pdb)
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3
W Xu, G Fischer, M Hyvonen, L Itzhaki
(2016)
(doi: 10.2210/pdb5bxo/pdb)
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2
M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, JE Stokes, YS Tan, EG Almeida, B Hardwick, AJ Narvaez, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Sci Rep
(2016)
6,
28528
(doi: 10.1038/srep28528)
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence
MM Wiedmann, S Aibara, DR Spring, M Stewart, JD Brenton
– Journal of structural biology
(2016)
195,
273
(doi: 10.1016/j.jsb.2016.06.018)
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
A Chattopadhyay, CJ O'Connor, F Zhang, C Galvagnion, WRJD Galloway, YS Tan, JE Stokes, T Rahman, C Verma, DR Spring, LS Itzhaki
– Sci Rep
(2016)
6,
23732
(doi: 10.1038/srep23732)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

    Study at Cambridge

    About the University

    Research at Cambridge