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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Stereocontrolled Semi-Syntheses of Elliptone and 12aβ-Hydroxyelliptone
DA Russell, WJS Fong, DG Twigg, HF Sore, DR Spring
– J Nat Prod
(2017)
80,
2751
(doi: 10.1021/acs.jnatprod.7b00527)
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa
AC McVey, P Medarametla, X Chee, S Bartlett, A Poso, DR Spring, T Rahman, M Welch
– Biochemistry
(2017)
56,
5539
(doi: 10.1021/acs.biochem.7b00852)
Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
– Angewandte Chemie
(2017)
129,
13046
(doi: 10.1002/ange.201705611)
Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes
YR Baker, JT Hodgkinson, BI Florea, E Alza, WRJD Galloway, L Grimm, SM Geddis, HS Overkleeft, M Welch, DR Spring
– Chemical Science
(2017)
8,
7403
(doi: 10.1039/c7sc01270e)
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction
DJ Cole, M Janecek, JE Stokes, M Rossmann, JC Faver, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring, DJ Huggins, WL Jorgensen
– Chem Commun (Camb)
(2017)
53,
9372
(doi: 10.1039/c7cc05379g)
Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
– Angewandte Chemie International Edition
(2017)
56,
12866
(doi: 10.1002/anie.201705611)
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
– Bioorg Med Chem
(2017)
25,
3471
(doi: 10.1016/j.bmc.2017.04.037)
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
JJ Ciardiello, WRJD Galloway, CJ O'Connor, HF Sore, JE Stokes, Y Wu, DR Spring
– Tetrahedron
(2017)
72,
3567
(doi: 10.1016/j.tet.2015.10.061)
Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes.
A Guarnieri-Ibáñez, F Medina, C Besnard, SL Kidd, DR Spring, J Lacour
– Chem Sci
(2017)
8,
5713
(doi: 10.1039/c7sc00964j)
Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1-42).
TH Sum, TJ Sum, S Collins, WRJD Galloway, DG Twigg, F Hollfelder, DR Spring
– Organic & biomolecular chemistry
(2017)
15,
4554
(doi: 10.1039/c7ob00804j)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

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    About the University

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