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Yusuf Hamied Department of Chemistry

 

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

Carboxyl pKa Values and Acid Denaturation of BBL
E Arbely, TJ Rutherford, H Neuweiler, TD Sharpe, N Ferguson, AR Fersht
– Journal of Molecular Biology
(2010)
403,
313
A transient and low-populated protein-folding intermediate at atomic resolution
DM Korzhnev, TL Religa, W Banachewicz, AR Fersht, LE Kay
– Science (New York, N.Y.)
(2010)
329,
1312
Refolding the Engrailed Homeodomain: Structural Basis for the Accumulation of a Folding Intermediate
ME McCully, DAC Beck, AR Fersht, V Daggett
– Biophysical Journal
(2010)
99,
1628
The human peripheral subunit‐binding domain folds rapidly while overcoming repulsive Coulomb forces
E Arbely, H Neuweiler, TD Sharpe, CM Johnson, AR Fersht
– Protein science : a publication of the Protein Society
(2010)
19,
1704
Highest paraoxonase turnover rate found in a bacterial phosphotriesterase variant.
L Briseño-Roa, Z Oliynyk, CM Timperley, AD Griffiths, AR Fersht
– Protein engineering, design & selection : PEDS
(2010)
24,
209
S100 proteins interact with the N-terminal domain of MDM2
J van Dieck, JK Lum, DP Teufel, AR Fersht
– FEBS Lett
(2010)
584,
3269
Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2
S Rajagopalan, A Andreeva, TJ Rutherford, AR Fersht
– Proc Natl Acad Sci U S A
(2010)
107,
8587
Transdisciplinary EU science institute needs funds urgently
JW Vasbinder, B Andersson, WB Arthur, M Boasson, R de Boer, JP Changeux, E Domingo, M Eigen, A Fersht, D Frenkel, M Rees, T Groen, R Huber, T Hunt, J Holland, R May, E Norrby, P Nijkamp, JM Lehn, R Rabbinge, M Scheffer, P Schuster, I Serageldin, J Stuip, J de Vries, W van Vierssen, R Willems
– Nature
(2010)
463,
876
The tumor suppressor p53: from structures to drug discovery.
AC Joerger, AR Fersht
– Cold Spring Harbor perspectives in biology
(2010)
2,
a000919
Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73
J van Dieck, T Brandt, DP Teufel, DB Veprintsev, AC Joerger, AR Fersht
– Oncogene
(2010)
29,
2024
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