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Recent Publications from the Biological Research Interest Group

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O'Neil, ND Santos, J Silvester, V Wei, J Garcia, F Kabeer, D Lai, P Soriano, J Banáth, DS Chiu, D Yap, DD Le, FB Ye, A Zhang, K Thu, J Soong, S-C Lin, AHC Tsai, T Osako, T Algara, DN Saunders, J Wong, J Xian, MB Bally, JD Brenton, GW Brown, SP Shah, D Cescon, TW Mak, C Caldas, PC Stirling, P Hieter, S Balasubramanian, S Aparicio
– Nat Commun
(2017)
8,
14432
G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.
AB Sahakyan, P Murat, C Mayer, S Balasubramanian
– Nature Structural & Molecular Biology
(2017)
Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania.
F Kawasaki, D Beraldi, RE Hardisty, GR McInroy, P van Delft, S Balasubramanian
– Genome Biol
(2017)
18,
23
A fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1
ME Kavanagh, J Chenge, A Zoufir, KJ McLean, AG Coyne, A Bender, AW Munro, C Abell
Cotranslational folding of spectrin domains via partially structured states.
OB Nilsson, AA Nickson, JJ Hollins, S Wickles, A Steward, R Beckmann, G von Heijne, J Clarke
– Nat Struct Mol Biol
(2017)
2′-O-methyl-5-hydroxymethylcytidine: A second oxidative derivative of 5-methylcytidine in RNA
SM Huber, P van Delft, A Tanpure, EA Miska, S Balasubramanian
– Journal of the American Chemical Society
(2017)
139,
1766
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E1009
Biomimetic Supramolecular Polymer Networks Exhibiting both Toughness and Self-Recovery
J Liu, CSY Tan, Z Yu, Y Lan, C Abell, OA Scherman
– Adv Mater
(2017)
Single genome retrieval of context-dependent variability in mutation rates for human germline
AB Sahakyan, S Balasubramanian
– BMC genomics
(2017)
18,
81
Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides.
F Kawasaki, P Murat, Z Li, T Santner, S Balasubramanian
– Chemical communications (Cambridge, England)
(2017)
53,
1389
Cucurbit[n]uril-Based Microcapsules Self-Assembled within Microfluidic Droplets: A Versatile Approach for Supramolecular Architectures and Materials.
J Liu, Y Lan, Z Yu, CSY Tan, RM Parker, C Abell, OA Scherman
– Accounts of Chemical Research
(2017)
Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop.
AN Borkar, P Vallurupalli, C Camilloni, LE Kay, M Vendruscolo
– Physical chemistry chemical physics : PCCP
(2017)
19,
2797
Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells
PMSD Cal, F Sieglitz, FMF Santos, C Parente Carvalho, A Guerreiro, JB Bertoldo, U Pischel, PMP Gois, GJL Bernardes
– Chemical communications (Cambridge, England)
(2016)
53,
368
The Amyloid Phenomenon and Its Links with Human Disease.
CM Dobson
– Cold Spring Harb Perspect Biol
(2017)
Principles of protein structural ensemble determination.
M Bonomi, GT Heller, C Camilloni, M Vendruscolo
– Current opinion in structural biology
(2017)
42,
106
Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.
L Perdios, AR Lowe, G Saladino, TD Bunney, N Thiyagarajan, Y Alexandrov, C Dunsby, PMW French, JW Chin, FL Gervasio, EW Tate, M Katan
– Scientific reports
(2017)
7,
39841
Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells.
E Jiménez-Moreno, Z Guo, BL Oliveira, IS Albuquerque, A Kitowski, A Guerreiro, O Boutureira, T Rodrigues, G Jiménez-Osés, GJL Bernardes
– Angew Chem Int Ed Engl
(2016)
56,
243
Aqueous interfacial gels assembled from small molecule supramolecular polymers
AS Groombridge, A Palma, RM Parker, C Abell, OA Scherman
– Chem. Sci.
(2016)
8,
1350
Networks of Dynamic Allostery Regulate Enzyme Function
MJ Holliday, C Camilloni, GS Armstrong, M Vendruscolo, EZ Eisenmesser
– Structure (London, England : 1993)
(2016)
25,
276
Characterization of the Folding of a 5<inf>2</inf>-Knotted Protein Using Engineered Single-Tryptophan Variants
H Zhang, SE Jackson
– Biophys J
(2016)
111,
2587