Systems-level organization of extracellular proteostasis
Science
(2026)
391
1332
(doi: 10.1126/science.aed3712)
Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis
ACS Chem Biol
(2026)
acschembio.5c00935
(doi: 10.1021/acschembio.5c00935)
Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras.
Nature chemistry
(2026)
1
(doi: 10.1038/s41557-026-02111-y)
OmniBind: Proteome-Wide Promiscuity Predictions for Early-Stage Drug Screening
(2026)
(doi: 10.64898/2026.03.17.712433)
The α-synuclein proteostasis network and its translational applications in Parkinson’s disease
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
e2513317123
(doi: 10.1073/pnas.2513317123)
Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating
(2026)
(doi: 10.64898/2026.03.10.710759)
FuzDrop: sequence-based prediction of the propensity of proteins for liquid-liquid phase separation and aggregation.
Nature protocols
(2026)
1
(doi: 10.1038/s41596-025-01267-0)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay (vol 147, pg 35942, 2025)
J Am Chem Soc
(2026)
148
12423
(doi: 10.1021/jacs.5c18723)
Toward a unified framework for determining conformational ensembles of disordered proteins.
Nature Methods
(2026)
1
(doi: 10.1038/s41592-026-03003-2)
Rational Design of Nanobodies Targeting LINGO‐1
Applied Research
(2026)
5
ARTN e70071
(doi: 10.1002/appl.70071)
Structural Plausibility Without Binding Specificity: Limits of AI-Based Antibody-Antigen Structure Prediction Confidence Scores
(2026)
(doi: 10.64898/2026.03.02.709004)
Dissecting the Binding Interactions of the Chromatin Remodeler SMARCA4 with G‑Quadruplex DNA
Biochemistry
(2026)
65
670
(doi: 10.1021/acs.biochem.5c00750)
Highly mutagenic continuous evolution in E. coli using a Φ29-based orthogonal replication system.
Nat Biotechnol
(2026)
1
(doi: 10.1038/s41587-025-02944-x)
Structural defects in amyloid-β fibrils drive secondary nucleation
Nature communications
(2026)
17
1933
(doi: 10.1038/s41467-026-69377-1)
Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations.
bioRxiv
(2026)
(doi: 10.64898/2026.02.14.705716)
Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification
Alzheimer's & Dementia
(2026)
22
e71112
(doi: 10.1002/alz.71112)
Disulphide and sequence-encoded conformational priors guide nanobody structure prediction
(2026)
(doi: 10.64898/2026.02.13.705647)
Metadiffusion: inference-time meta-energy biasing of biomolecular diffusion models
(2026)
(doi: 10.64898/2026.02.10.704873)
Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features
Nat Commun
(2026)
17
2591
(doi: 10.1038/s41467-026-69429-6)
Understanding biology with machine learning: compression, intelligibility, and dependency
Artificial Intelligence in the Life Sciences
(2026)
9
100161
(doi: 10.1016/j.ailsci.2026.100161)
A Bifunctional Small Molecule Degrader of the Long Non-Coding RNA MALAT1 Triplex
Chemistry - A European Journal
(2026)
e00025
(doi: 10.1002/chem.202600025)
Molecularly specific solubilization of therapeutic antibodies
(2026)
(doi: 10.64898/2026.01.29.702671)
5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer
Communications medicine
(2026)
6
15
(doi: 10.1038/s43856-025-01278-8)
Microglial Activation and Alpha-Synuclein Oligomers Drive the Early Inflammatory Phase of Parkinson's Disease
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2026)
52