Yusuf Hamied Department of Chemistry

Recent Publications from the Biological Research Interest Group

Understanding Transition Metal Chemistry
S Boss, P Barker, J Field, A Peel
(2026)
(doi: 10.1039/9781837676347)
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
SJ Resnick, S Qamar, P Krishna, V Korobeynikov, H Ausserwoger, A Miller, P Esposito, JA Varela, J Sheng, LH Huang, J Nixon-Abell, S Melore, CW Chung, NF Läubli, S Kapsiani, X Li, J Wang, N Zhang, MM Alam, AS Burguete, TC Swayne, Y Chen, Y-C Liao, NA Shneider, M Vendruscolo, TPJ Knowles, CF Kaminski, FS Ruggeri, GS Kaminski Schierle, P St George-Hyslop, A Chavez
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-65178-0)
Binding Paths: Describing Small Molecule Interactions with Disordered Proteins via Markov State Models
A Louet, G Hummer, M Vendruscolo
(2025)
(doi: 10.1101/2025.11.19.688850)
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding
Y-H Lee, T Saio, M Watabe, M Matsusaki, S Kanemura, Y Lin, T Mannen, T Kuramochi, Y Kamada, K Iuchi, M Tajiri, K Suzuki, Y Li, Y Heo, K Ishii, K Arai, K Ban, M Hashimoto, S Oshita, S Ninagawa, Y Hattori, H Kumeta, A Takeuchi, S Kajimoto, H Abe, E Mori, T Muraoka, T Nakabayashi, S Akashi, T Okiyoneda, M Vendruscolo, K Inaba, M Okumura
Nature cell biology
(2025)
27
(doi: 10.1038/s41556-025-01794-8)
A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery
I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes
Angewandte Chemie International Edition
(2025)
(doi: 10.1002/anie.202513808)
A Cathepsin B-Triggered CO-Releasing Molecule with a Non-Toxic Metal Core for Targeted Tumor Delivery.
I Černauskienė, E Izquierdo-García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes
Angew Chem Int Ed Engl
(2025)
(doi: 10.1002/anie.202513808)
A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery
I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes
Angewandte Chemie
(2025)
(doi: 10.1002/ange.202513808)
Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using Deep Docking
M Brezinova, ZF Brotzakis, RI Horne, V Roy Chowdhury, RC Gregory, Y Bian, A González Díaz, F Gentile, M Vendruscolo
Molecular systems biology
(2025)
(doi: 10.1038/S44320-025-00159-5)
Escherichia coli with a 57-codon genetic code.
WE Robertson, FBH Rehm, M Spinck, RL Schumann, R Tian, W Liu, Y Gu, AA Kleefeldt, CF Day, KC Liu, Y Christova, JF Zürcher, FL Böge, J Birnbaum, L van Bijsterveldt, JW Chin
Science (New York, N.Y.)
(2025)
390
(doi: 10.1126/science.ady4368)
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
(doi: 10.21203/rs.3.rs-7375981/v1)
Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
Nature Biomedical Engineering
(2025)
(doi: 10.1038/s41551-025-01496-4)
Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau
A Santambrogio, S Lövestam, MA Metrick, T Löhr, P Xu, NCT Gallagher, B Ghetti, B Caughey, SHW Scheres, M Vendruscolo
FEBS Letters
(2025)
599
(doi: 10.1002/1873-3468.70141)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, T Knowles, M Vendruscolo
Communications Chemistry
(2025)
8
(doi: 10.1038/S42004-025-01659-Z)
Advances in Proximity-Assisted Bioconjugation.
M Canzano, GJL Bernardes
Accounts of Chemical Research
(2025)
58
(doi: 10.1021/acs.accounts.5c00368)
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
EE Prescott, J Wei, EF Garland, A Urbanek, F Capriglia, WH Molenkamp, DP Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, MO Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, JR Highly, TPJ Knowles, H Mortiboys, S De
(2025)
(doi: 10.1101/2025.09.17.676873)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay
A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
Journal of the American Chemical Society
(2025)
147
(doi: 10.1021/jacs.5c12812)
Tumour-specific STING agonist synthesis via a two-component prodrug system
N-S Hsu, C Tang, RV Mendes, C Labão-Almeida, CV Dos Reis, AR Coelho, MC Marques, M Cabeza Cabrerizo, R Misteli, TPC Rooney, M Hyvönen, F Corzana, R Fior, GJL Bernardes
Nature Chemistry
(2025)
17
(doi: 10.1038/s41557-025-01930-9)
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi
(2025)
(doi: 10.1101/2025.08.25.671921)
Rapid elongation drives the exceptionally fast aggregation of medin, the most common localized human amyloid
M Vendruscolo, VR Chowdhury, R Horne, M Cali, Z Toprakcioglu, S Linse
(2025)
(doi: 10.21203/rs.3.rs-6476074/v1)
α-Synuclein driven cell susceptibility in Parkinson’s disease
JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee
(2025)
(doi: 10.1101/2025.08.19.670819)
[2.2.1]Heterobicyclic Bromovinyl Sulfones for Thiol-Triggered Strategies in Linker Chemistry: Aza- vs Oxa-Norbornadienic Systems
M Carranza, AT Carmona, C Maya, E Gil de Montes, AV Vasco, GJL Bernardes, AJ Moreno-Vargas
Bioconjugate chemistry
(2025)
36
(doi: 10.1021/acs.bioconjchem.5c00371)
An unnatural base pair for the detection of epigenetic cytosine modifications in DNA.
D Schmidl, SM Becker, JM Edgerton, S Balasubramanian
Nature Chemistry
(2025)
17
(doi: 10.1038/s41557-025-01925-6)
Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model
H Zhang, RI Horne, ZF Brotzakis, C Harris, P Liò, M Vendruscolo
(2025)
(doi: 10.1101/2025.08.16.670694)
Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders
MD Overath, ASH Rygaard, CP Jacobsen, V Brasas, O Morell, P Sormanni, TP Jenkins
(2025)
(doi: 10.1101/2025.08.14.670059)
Correction: Modifying recombinant purple acid phosphatase using computational design
A Venkatramani, M Ali, O Predeina, JC Molloy, P Sormanni, EAH Hall
Eur Biophys J
(2025)
(doi: 10.1007/s00249-025-01792-6)
Yusuf Hamied Department of Chemistry
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T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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