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Recent Publications from the Biological Research Interest Group

Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling.
WD Lambert, SL Scinto, O Dmitrenko, SJ Boyd, R Magboo, RA Mehl, JW Chin, JM Fox, S Wallace
– Org Biomol Chem
(2017)
15,
6640
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide.
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, M Vendruscolo
– Journal of molecular biology
(2017)
Silk micrococoons for protein stabilisation and molecular encapsulation
U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles
– Nature Communications
(2017)
8,
15902
The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases.
N Cremades, CM Dobson
– Neurobiology of disease
(2017)
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease
R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E5703
Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
201700239
Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species
M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
– BMC biology
(2017)
15,
57
Inverse electron demand Diels-Alder reactions in chemical biology.
BL Oliveira, Z Guo, GJL Bernardes
– Chemical Society reviews
(2017)
46,
4895
Ultrasensitive Measurement of Ca<sup>2+</sup> Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angew Chem Int Ed Engl
(2017)
56,
7750
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.
R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E5703
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Sci Adv
(2017)
3,
e1700488
Direct Conversion of an Enzyme from Native-like to Amyloid-like Aggregates within Inclusion Bodies
F Elia, F Cantini, F Chiti, CM Dobson, F Bemporad
– Biophys J
(2017)
112,
2540
Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis
JA Gramespacher, AJ Stevens, DP Nguyen, JW Chin, TW Muir
– Journal of the American Chemical Society
(2017)
139,
8074
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.
A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, A Carnerup, CM Dobson, M Vendruscolo, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
6444
The Amyloid Phenomenon and Its Links with Human Disease
CM Dobson
– COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2017)
9,
ARTN a023648
Biosynthesis and genetic encoding of phosphothreonine through parallel setection and deep sequencing
MS Zhang, SF Brunner, N Huguenin-Dezot, AD Liang, WH Schmied, DT Rogerson, JW Chin
– Nature methods
(2017)
14,
729
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays
PO Nikiforov, M Blaszczyk, S Surade, HI Boshoff, A Sajid, V Delorme, N Deboosere, P Brodin, AR Baulard, CE Barry, TL Blundell, C Abell
– ACS Chem Biol
(2017)
12,
1390
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
F Chiti, CM Dobson
– Annual Review of Biochemistry
(2017)
86,
27
Structural basis of synaptic vesicle assembly promoted by alpha-synuclein (vol 7, 12563, 2016)
G Fusco, T Pape, AD Stephens, P Mahou, AR Costa, CF Kaminski, GSK Schierle, M Vendruscolo, G Veglia, CM Dobson, A De Simone
– Nature Communications
(2017)
8,
15667
Frontispiece: Site-Selective Modification of Proteins with Oxetanes
O Boutureira, N Martínez-Sáez, KM Brindle, AA Neves, F Corzana, GJL Bernardes
– Chemistry - A European Journal
(2017)
23,