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Recent Publications from the Biological Research Interest Group

MOAG-4 Promotes the Aggregation of α-Synuclein by Competing with Self-Protective Electrostatic Interactions.
Y Yoshimura, MA Holmberg, P Kukic, CB Andersen, A Mata-Cabana, SF Falsone, M Vendruscolo, EAA Nollen, FAA Mulder
– J Biol Chem
(2017)
Simultaneous quantification of protein order and disorder.
P Sormanni, D Piovesan, GT Heller, M Bonomi, P Kukic, C Camilloni, M Fuxreiter, Z Dosztanyi, RV Pappu, MM Babu, S Longhi, P Tompa, AK Dunker, VN Uversky, SCE Tosatto, M Vendruscolo
– Nat Chem Biol
(2017)
13,
339
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.
O Sin, T de Jong, A Mata-Cabana, M Kudron, MA Zaini, FA Aprile, RI Seinstra, E Stroo, RW Prins, CN Martineau, HH Wang, W Hogewerf, A Steinhof, EE Wanker, M Vendruscolo, CF Calkhoven, V Reinke, V Guryev, EAA Nollen
– Mol Cell
(2017)
65,
1096
Multisite aggregation of p53 and implications for drug rescue.
G Wang, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
Site-Selective Modification of Proteins with Oxetanes.
O Boutureira, N Martínez-Sáez, KM Brindle, AA Neves, F Corzana, GJL Bernardes
– Chemistry
(2017)
G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.
AB Sahakyan, P Murat, C Mayer, S Balasubramanian
– Nature Structural & Molecular Biology
(2017)
24,
243
Cotranslational folding of spectrin domains via partially structured states.
OB Nilsson, AA Nickson, JJ Hollins, S Wickles, A Steward, R Beckmann, G von Heijne, J Clarke
– Nat Struct Mol Biol
(2017)
24,
221
Widespread Proteome Remodeling and Aggregation in Aging C. elegans.
DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo, M Mann, FU Hartl
– Cell
(2017)
168,
944
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades
– Biochemistry
(2017)
56,
1177
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
R Hänsel-Hertsch, MD Antonio, S Balasubramanian
– Nature Reviews Molecular Cell Biology
(2017)
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O'Neil, ND Santos, J Silvester, V Wei, J Garcia, F Kabeer, D Lai, P Soriano, J Banáth, DS Chiu, D Yap, DD Le, FB Ye, A Zhang, K Thu, J Soong, S-C Lin, AHC Tsai, T Osako, T Algara, DN Saunders, J Wong, J Xian, MB Bally, JD Brenton, GW Brown, SP Shah, D Cescon, TW Mak, C Caldas, PC Stirling, P Hieter, S Balasubramanian, S Aparicio
– Nature Communications
(2017)
8,
14432
Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action
JW Ndieyira, J Bailey, SB Patil, M Vögtli, MA Cooper, C Abell, RA McKendry, G Aeppli
– Scientific reports
(2017)
7,
41206
Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.
I Milagre, TM Stubbs, MR King, J Spindel, F Santos, F Krueger, M Bachman, A Segonds-Pichon, S Balasubramanian, SR Andrews, W Dean, W Reik
– Cell Rep
(2017)
18,
1079
Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania.
F Kawasaki, D Beraldi, RE Hardisty, GR McInroy, P van Delft, S Balasubramanian
– Genome Biol
(2017)
18,
23
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
JT Chenge, LV Duyet, S Swami, KJ McLean, ME Kavanagh, AG Coyne, SEJ Rigby, MR Cheesman, HM Girvan, CW Levy, B Rupp, JP von Kries, C Abell, D Leys, AW Munro
– J Biol Chem
(2017)
292,
1310
A fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1
ME Kavanagh, J Chenge, A Zoufir, KJ McLean, AG Coyne, A Bender, AW Munro, C Abell
– Biochemistry
(2017)
2′-O-methyl-5-hydroxymethylcytidine: A second oxidative derivative of 5-methylcytidine in RNA
SM Huber, P van Delft, A Tanpure, EA Miska, S Balasubramanian
– Journal of the American Chemical Society
(2017)
139,
1766
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E1009
Biomimetic Supramolecular Polymer Networks Exhibiting both Toughness and Self-Recovery
J Liu, CSY Tan, Z Yu, Y Lan, C Abell, OA Scherman
– Adv Mater
(2017)
29,
UNSP 1604951
Single genome retrieval of context-dependent variability in mutation rates for human germline
AB Sahakyan, S Balasubramanian
– BMC genomics
(2017)
18,
81