Yusuf Hamied Department of Chemistry

Recent Publications from the Biological Research Interest Group

Understanding Transition Metal Chemistry
S Boss, P Barker, J Field, A Peel
(2026)
(doi: 10.1039/9781837676347)
Plasmodium thiamine pyrophosphokinase is essential for sporozoite formation and activation of an antiplasmodial thiamine analogue
I Fathoni, ÜY Kina, AHY Chan, J Lee, TCS Ho, M Rauch, P Martin, EA Meissner, T Stach, FJ Leeper, M Rug, K Matuschewski, KJ Saliba
Proceedings of the National Academy of Sciences
(2026)
123
(doi: 10.1073/pnas.2534594123)
Multimerization of a rationally designed nanobody for enhanced avidity toward Aβ42 oligomers.
M Nowinska, E Suh, C Mogilevsky, M Vendruscolo
Protein Sci
(2026)
35
(doi: 10.1002/pro.70754)
Correction to “Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression”
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, B Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, C Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes
ACS Central Science
(2026)
(doi: 10.1021/acscentsci.6c01291)
Structure–Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers
S Errico, A Bigi, G Fani, M Ambrosino, E Galmiche, F Bemporad, M Vendruscolo, B Mannini, F Chiti
Journal of Medicinal Chemistry
(2026)
69
(doi: 10.1021/acs.jmedchem.6c01682)
Perceptions on Accessible Mentorship and Barriers to Subspecialty Training: A Comparison Study in URiM and Non-URiM Pediatric Cardiology Trainees
OM Cox, P Yalavarthi, A Duimstra, R Lowery, S Yu, CS Goldberg, CA Gilliam, S Balasubramanian, AD McCormick
Pediatric Cardiology
(2026)
(doi: 10.1007/s00246-026-04385-y)
Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissue
A Röntgen, G Fusco, J Breiter, JS Beckwith, J Lachica, CE Toomey, J Singh, O Klementieva, S Gandhi, S Lee, A De Simone, Z Toprakcioglu, M Vendruscolo
(2026)
(doi: 10.64898/2026.07.05.736591)
Complex coacervation reshapes the aggregation landscape of tau
Z Han, P Xu, Y Ou, D Qian, Z Xiao, Y Wu, A Santambrogio, M Vendruscolo, TPJ Knowles
(2026)
(doi: 10.64898/2026.06.27.734011)
Postoperative changes in cervical hemodynamics and cognitive function following cervical lymphatic-venous surgery in Alzheimer's disease
X Zheng, C Tang, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, Q Shi, GJL Bernardes
Journal of Alzheimer's disease : JAD
(2026)
112
(doi: 10.1177/13872877261459037)
Editorial overview: Folding, binding and protein design.
J Christodoulou, M Vendruscolo
Curr Opin Struct Biol
(2026)
99
(doi: 10.1016/j.sbi.2026.103306)
Preserving Native Cellulose–Xylan Architecture Enables Structure–Property Control in Holocellulose Nanofibrils and High-Performance Sustainable Materials
PK Deralia, R Cresswell, Y Yoshimi, T Kuga, A Echevarría-Poza, P Howell, A Dickson, MJ Le Guen, E Wagner, ACS de Alcântara, CGT Batista, N Follain, A Miller, M Vendruscolo, SJ Hill, J Beaugrand, MS Skaf, DJ Cosgrove, SP Brown, JA Elliott, R Dupree, P Dupree
(2026)
(doi: 10.64898/2026.06.07.730583)
Dynamic palladium speciation governs prodrug activation by nanoparticles in vitro and in vivo.
E Latocheski, GMD Forno, JP Agnes, J Konč, A Zanotto-Filho, GJL Bernardes, JB Domingos
Colloids and Surfaces B Biointerfaces
(2026)
267
(doi: 10.1016/j.colsurfb.2026.115902)
In vitro and in vivo inhibition of amyloid β aggregation by a Ru(II)-naphthalene diimide complex.
MA Tiburcio, MP Cali, LMB Pereira, AE Graminha, I Atienza-Navarro, M Vendruscolo, M Garcia-Alloza, RM Carlos
Dalton Transactions
(2026)
55
(doi: 10.1039/d5dt02853a)
Prediction of antibody non-specificity using protein language models and biophysical parameters
LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata
MAbs
(2026)
18
(doi: 10.1080/19420862.2026.2678000)
Effects of PTMs on Tau Protein Aggregation: Insights from HCG and Atomistic MD Simulations
A Louet, J Stuke, L Pietrek, M Vendruscolo, G Hummer
(2026)
(doi: 10.64898/2026.05.22.727278)
Does the sequence of a disordered protein encode small molecule binding paths?
A Louet, G Hummer, M Vendruscolo
(2026)
(doi: 10.64898/2026.05.20.726646)
Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues
G Battistoni, S Torres-Garcia, CY Sia, S Corriero, C Boquetale, E Williams, A Cregeen, K Wasilewska, M Alini, N Hemmer, IMAXT Cancer Grand Challenge Consortium, S Balasubramanian, BC Nicholson, GJ Hannon, D Bressan
Proc Natl Acad Sci U S A
(2026)
123
(doi: 10.1073/pnas.2527896123)
Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments
G Lopes Bernardes
Journal of Experimental Medicine
(2026)
223
(doi: 10.1084/jem.20252133)
Glutathione-responsive fragmentation of heteronorbornadiene-based thiovinyl sulfones in glioma cells
M Carranza, AT Carmona, E Gil de Montes, Y Méndez, I Černauskienė, GJL Bernardes, AJ Moreno-Vargas
Bioconjug Chem
(2026)
37
(doi: 10.1021/acs.bioconjchem.5c00581)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
(doi: 10.64898/2026.04.08.715690)
Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin.
V Roy Chowdhury, RI Horne, MP Cali, Z Toprakcioglu, S Linse, M Vendruscolo
Communications chemistry
(2026)
9
(doi: 10.1038/s42004-026-01950-7)
Microglia as transcriptional pacemakers of neuronal aging heterogeneity across individuals
CM Lim, M Vendruscolo
(2026)
(doi: 10.64898/2026.04.05.716624)
Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2.
A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni
Mabs
(2026)
18
(doi: 10.1080/19420862.2026.2646361)
Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles.
MK Karabova, A Del Ser-Badia, A Hedegaard, SJ Washer, Z Baykam, DP O'Brien, I Vendrell, SS Hester, R Fischer, E Johnson, CE Melia, TRS Matthews-Palmer, R Matadeen, A Santambrogio, MA Metrick, M Vendruscolo, S Keeling, KAX Cheam, WA McEwan, KS Kosik, TA Day, WS James, SA Cowley
Alzheimers Dement
(2026)
22
(doi: 10.1002/alz.71337)
Systems-level organization of extracellular proteostasis
CM Gomes, M Vendruscolo
Science
(2026)
391
(doi: 10.1126/science.aed3712)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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