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Yusuf Hamied Department of Chemistry

 
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
– Nat Biomed Eng
(2025)
1
Nano-org, a functional resource for single-molecule localisation microscopy data
S Shirgill, DJ Nieves, JA Pike, MA Ahmed, H Abbott, MHH Baragilly, K Savoye, JD Worboys, KS Hazime, E Bruggeman, A Garcia, DJ Williamson, P Rubin-Delanchy, R Peters, DM Davis, R Henriques, SF Lee, DM Owen
– Nat Commun
(2025)
16,
8674
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, TPJ Knowles, M Vendruscolo
– Communications Chemistry
(2025)
8,
284
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation.
N Quittot, D Sivasankaran, D Boeken, Y Chen, JE Chun, A Wiedmer, V Derosla, MBMS Martins, FA Brooks, G Meisl, M Cotton, DG Arumuganainar, T Connors, A Melloni, M Frosch, D Oakley, L Makowski, M Wanunu, D Klenerman, BT Hyman
– bioRxiv
(2025)
2025.09.24.678227
Highly oxygenated molecules (HOMs) and secondary organic aerosol (SOA) formation from the oxidation of α- and β-phellandrenes by NO3 radicals
S Harb, M Cirtog, S Alage, C Cantrell, M Cazaunau, V Michoud, E Pangui, A Bergé, C Giorio, F Battaglia, B Picquet-Varrault
– Atmospheric Chemistry and Physics
(2025)
25,
11003
Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-positive Assemblies in Motor Neuron Disease
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
– Adv Sci (Weinh)
(2025)
e05484
Optofluidic waveguides for the label-free study of silk protein aggregates
JR Heck, Z Toprakcioglu, TE Naegele, MH Frosz, TPJ Knowles, TG Euser
– ACS Omega
(2025)
10,
46115
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease
E Fertan, S Kedia, G Meisl, MW Cotton, A Quaegebeur, MG Spillantini, D Klenerman
(2025)
T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts
M Kotowski, DF Heraghty, M Körbel, D Banik, Z Zhang, S Kedia, B Fu, J McColl, B Li, J Clarke, M Fellermeyer, Y Lui, G Bossi, DK Cole, H Chen, E Basiarz, S Sharma, E Petsalaki, CJ Tape, B de Wet, SF Lee, AM Santos, D Klenerman, SJ Davis
(2025)
Nanoscopic tau aggregates in Parkinson’s disease
F Layburn, D Boeken, YP Zhang, K Halliday, D Rodgers, L Kahanawita, B Patel, A Quaegebeur, CH Williams-Gray, D Klenerman
(2025)
Direct, high-throughput linking of single cell imaging and gene expression
C Xu, G Meisl, N Moshkov, K Goda, A Shkarin, M Schlögel, TPJ Knowles, L Mazutis, J Guck
(2025)
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
J Evans, M Grant-Peters, J Beckwith, C Toomey, R Popovic, J Breiter, J Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, E Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, R Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, M Horrocks, M Vendruscolo, N Wood, S Lee, M Ryten, S Gandhi
(2025)
Evaluation of UKESM aerosol size and composition using ATom measurements indicates missing marine aerosol formation mechanisms
X-C He, NL Abraham, H Ding, MR Russo, DP Grosvenor, Y Ge, X Wang, AC Jones, P Campuzano-Jost, B Nault, A Kupc, D Blake, JL Jimenez, CJ Williamson, KS Carslaw, J Weber, AT Archibald, H Gordon
(2025)
Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior.
J Wen, Y Tang, T Sneideris, H Ausserwöger, L Hong, TPJ Knowles, S Perrett, G Wei, S Wu
– Jacs Au
(2025)
5,
4268
α-Synuclein driven cell susceptibility in Parkinson’s disease
J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo, S Lee
(2025)
Spatial transmission of the Alzheimer’s amyloid beta peptide by secondary oligomers
T Knowles, Q Peter, C Taylor, U Lapinska, J Wei, T Michaels, P Arosio, S Linse
(2025)
Model Agnostic Conditioning of Boltzmann Generators for Peptide Cyclization
B du Pont, A Abrudan, R Scrutton, V Radenkovic, H Zhao, T Knowles
(2025)
Current practices in the study of biomolecular condensates: a community comment.
S Alberti, P Arosio, RB Best, S Boeynaems, D Cai, R Collepardo-Guevara, GL Dignon, R Dimova, S Elbaum-Garfinkle, NL Fawzi, M Fuxreiter, AS Gladfelter, A Honigmann, A Jain, JA Joseph, TPJ Knowles, K Lasker, EA Lemke, K Lindorff-Larsen, R Lipowsky, J Mittal, S Mukhopadhyay, S Myong, RV Pappu, K Rippe, TA Shelkovnikova, AG Vecchiarelli, S Wegmann, H Zhang, M Zhang, C Zubieta, M Zweckstetter, D Dormann, T Mittag
– Nature communications
(2025)
16,
7730
Quantifying collective interactions in biomolecular phase separation
H Ausserwöger, E de Csilléry, D Qian, G Krainer, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles
– Nature communications
(2025)
16,
7724