Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson’s disease brains
E Fertan, JSH Danial, S Neame, JYL Lam, MW Cotton, M Burke, Z Xia, Y Wu, B Powney, Y Imaizumi, A Quaegebeur, G Meisl, J Staddon, D Klenerman
Cell reports methods
(2026)
The role of N-terminal acetylation on biomolecular condensation
C G Oliveira, MTS Silva, E Kava, T Agarwal, G Cereghetti, E F Vicente, TPJ Knowles, AJ Costa-Filho, LFS Mendes
Commun Chem
(2026)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer
S Chakraborty, J Pramanik, G Alviter-Raymundo, CJ Ward, SK Shaji, Y Yamashita-Kanemaru, FAZ Ali, D Banik, Z Zhang, C Veiga-Villauriz, NZM Homer, J Simpson, S Laforest, S Tong, Q Zhao, J Roy, M Iqbal, AC Morris, MA Chapman, R Roychoudhuri, H Hussein, D Klenerman, K Saeb-Parsy, B Mahata
Signal Transduction and Targeted Therapy
(2026)
11
A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells
W Hong, Z Zhang, A Li, T Sun, Y Wu, DM Vadukul, D Jones, B Li, F Liu, FA Aprile, Y Korchev, J Gorelik, D Klenerman, A Shevchuk
Advanced Science
(2026)
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates.
L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles
Adv Sci (Weinh)
(2026)
A swarm intelligence approach to density function reconstruction from moments using entropy optimization.
P Biswas, SR Elliott
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
Discovery of first-in-class YTHDC1 small molecule inhibitors for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, MJ Rawling, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, A Howarth, S Qamar, L Andraghetti, A Seeber, MG Kharas, S Cohen, M Kulander, T Knowles, S Arora
Cancer Research
(2026)
86
NPM1 Undergoes Salt‐Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk
Y Zhen, Y Tan, Y Tang, T Sneideris, H Ausserwöger, J Wen, TPJ Knowles, S Perrett, G Wei, S Wu
Small (Weinheim an der Bergstrasse, Germany)
(2026)
Introducing Volatile Organic Compound Model Intercomparison Project (VOCMIP)
G Myhre, Ø Hodnebrog, S Krishnan, M Sand, M Sandstad, RB Skeie, L Clarisse, B Franco, DB Millet, KC Wells, A Archibald, HN Bryant, AT Chaudhri, DS Stevenson, D Hauglustaine, M Prather, JC Kaiser, DJL Olivie, M Schulz, O Wild, Y Wang, T Salameh, JE Williams, P Le Sager, F Paulot, K Tsigaridis, HE Plaas
Geoscientific Model Development
(2026)
19
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits.
R Ellingford, SS Harris, M Kehring, RM Rajani, FKW Lam, D Graykowski, D Bӧken, LA Welikovitch, A Khasnavis, R Laban, A Heslegrave, U Yaman, A Mate de Gerando, SA Bond, S Wray, DA Salih, D Dupret, RJ Dolan, D Klenerman, H Zetterberg, BT Hyman, MA Busche
Neuron
(2026)
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers.
H Yuan, Z Yang, C Yuan, S Shankar, A Levin, T Lv, Z Wang, W Sun, J Sitton, P-A Cazade, Y Dan, Y Tang, L Adler-Abramovich, Y Cao, S Rencus-Lazar, D Thompson, D Kurouski, TPJ Knowles, LJW Shimon, G Wei, B Xue, R Yang, E Gazit
Nat Commun
(2026)
Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner.
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
Proc Natl Acad Sci U S A
(2026)
123
Chemical softness as a predictor for reactivity at metal surfaces
AL Gunton, SJ Jenkins
Phys Chem Chem Phys
(2026)
28
Evaluation of UKESM aerosol size and composition using ATom measurements indicates missing marine aerosol formation mechanisms
X-C He, NL Abraham, H Ding, MR Russo, DP Grosvenor, Y Ge, X Wang, AC Jones, P Campuzano-Jost, B Nault, A Kupc, D Blake, JL Jimenez, CJ Williamson, J Weber, AT Archibald, H Gordon
Atmospheric Chemistry and Physics (ACP)
(2026)
26
Organic matter in dust-dominated aerosols over Namibia influenced by biomass burning and marine emissions
A Zherebker, C Baldo, P Formenti, C Giorio
(2026)
Chemical composition differences in gas- and particle-phase organic and DMS-derived oxidation products between a pristine marine environment and a wildfire-influenced marine air mass
F Sari Doré, R Wu, E Matthews, C Wu, T Bannan, H Coe, A Archibald, M Hallquist
(2026)
Reversibility and β-sheet formation are decoupled in tau condensate aging
CM Fischer, IA Edu, T Šneideris, I Baronaite, Z Toprakcioglu, L-T Deck, D Qian, R Scrutton, L Dreyer, J Wen, DE Otzen, S Wu, S Perrett, TPJ Knowles
Proceedings of the National Academy of Sciences
(2026)
123
Determining the key sources of uncertainty in dimethyl sulfide and methanethiol oxidation under tropical, temperate, and polar marine conditions
LSD Jacob, BEH Harvey, C Giorio, AT Archibald
Atmospheric Chemistry and Physics
(2026)
26
Constructing a single-objective oblique plane microscope (OPM) for fast, multi-colour, high-resolution volumetric fluorescence imaging
Z Zhang, W Hong, Y Wu, A Dey, A Shevchuk, D Klenerman
(2026)
Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome.
MC Moncrieffe, P Suresh, J Boyle, Y Cui, B Nawalpuri, B Verstak, YP Zhang, Z Zhang, M Taylor, EH Egelman, N Gay, D Klenerman, C Bryant
Science advances
(2026)
12
Charge-triggered switching mechanism in selenium selector enabling ultralow leakage current
Y Sun, T Gotoh, J Zhao, M Zhang, S Shi, H Zhang, Z Liu, J Shen, R Dronskowski, Z Song, SR Elliott, M Zhu
Nature materials
(2026)
25
Scaling Relations of Multicomponent Phase Coexistence Boundaries
D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles
PRX Life
(2026)
4
Development of Fully Interactive Hydrogen with Methane in UKESM1.0
M Brown
Geoscientific Model Development
(2026)
19
Liquid-liquid phase separation modulates protein pathological aggregation
Y Shen, TP Knowles, DA Weitz, D Vigolo, T Li, D Ilhamsyah
BIOPHYSICAL JOURNAL
(2026)
125