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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Physical Research Interest Group

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts
M Kotowski, DF Heraghty, M Körbel, D Banik, Z Zhang, S Kedia, B Fu, J McColl, B Li, J Clarke, M Fellermeyer, Y Lui, G Bossi, DK Cole, H Chen, E Basiarz, S Sharma, E Petsalaki, CJ Tape, B de Wet, SF Lee, AM Santos, D Klenerman, SJ Davis
(2025)
(DOI: 10.1101/2025.08.29.673015)
Nanoscopic tau aggregates in Parkinson’s disease
F Layburn, D Boeken, Y Zhang, K Halliday, D Rodgers, L Kahanawita, B Patel, A Quaegebeur, CH Williams-Gray, D Klenerman
(2025)
(DOI: 10.1101/2025.08.28.672923)
Direct, high-throughput linking of single cell imaging and gene expression
CK Xu, G Meisl, N Moshkov, K Goda, A Shkarin, MF Schlögel, TPJ Knowles, L Mazutis, J Guck
(2025)
(DOI: 10.1101/2025.09.01.672798)
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi
(2025)
(DOI: 10.1101/2025.08.25.671921)
Evaluation of UKESM aerosol size and composition using ATom measurements indicates missing marine aerosol formation mechanisms
X-C He, NL Abraham, H Ding, MR Russo, DP Grosvenor, Y Ge, X Wang, AC Jones, P Campuzano-Jost, B Nault, A Kupc, D Blake, JL Jimenez, CJ Williamson, KS Carslaw, J Weber, AT Archibald, H Gordon
(2025)
(DOI: 10.5194/egusphere-2025-3700)
Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior
J Wen, Y Tang, T Sneideris, H Ausserwöger, L Hong, TPJ Knowles, S Perrett, G Wei, S Wu
– JACS Au
(2025)
jacsau.5c00625
(DOI: 10.1021/jacsau.5c00625)
α-Synuclein driven cell susceptibility in Parkinson’s disease
JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee
(2025)
(DOI: 10.1101/2025.08.19.670819)
Spatial transmission of the Alzheimer’s amyloid beta peptide by secondary oligomers
T Knowles, Q Peter, C Taylor, U Lapinska, J Wei, T Michaels, P Arosio, S Linse
(2025)
(DOI: 10.21203/rs.3.rs-7035767/v1)
Model Agnostic Conditioning of Boltzmann Generators for Peptide Cyclization
B du Pont, A Abrudan, R Scrutton, V Radenkovic, H Zhao, T Knowles
(2025)
(DOI: 10.1101/2025.08.15.670426)
Current practices in the study of biomolecular condensates: a community comment
S Alberti, P Arosio, RB Best, S Boeynaems, D Cai, R Collepardo-Guevara, GL Dignon, R Dimova, S Elbaum-Garfinkle, NL Fawzi, M Fuxreiter, AS Gladfelter, A Honigmann, A Jain, JA Joseph, TPJ Knowles, K Lasker, EA Lemke, K Lindorff-Larsen, R Lipowsky, J Mittal, S Mukhopadhyay, S Myong, RV Pappu, K Rippe, TA Shelkovnikova, AG Vecchiarelli, S Wegmann, H Zhang, M Zhang, C Zubieta, M Zweckstetter, D Dormann, T Mittag
– Nature Communications
(2025)
16,
7730
(DOI: 10.1038/s41467-025-62055-8)
Quantifying collective interactions in biomolecular phase separation.
H Ausserwöger, E de Csilléry, D Qian, G Krainer, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles
– Nature communications
(2025)
16,
7724
(DOI: 10.1038/s41467-025-62437-y)
Design and Characterisation of a Thin Plate Heat Exchanger for Fouling Studies
J Brown, SM Clarke, G Kawaley, MJ Sargent, MA Turner, DI Wilson
– Heat and Mass Transfer
(2025)
61,
75
(DOI: 10.1007/s00231-025-03592-2)
A Charge-Driven Strategy for Covalent Modification and Modulation of Biomolecular Condensates
Z Chen, L Liu, J Cattin, TPJ Knowles, GJL Bernardes
– Journal of the American Chemical Society
(2025)
147,
28558
(DOI: 10.1021/jacs.5c06625)
Opinion: The role of AerChemMIP in advancing climate and air quality research
PT Griffiths, LJ Wilcox, RJ Allen, V Naik, FM O'Connor, M Prather, A Archibald, F Brown, M Deushi, W Collins, S Fiedler, N Oshima, LT Murray, BH Samset, C Smith, S Turnock, D Watson-Parris, PJ Young
– Atmospheric Chemistry and Physics
(2025)
25,
8289
(DOI: 10.5194/acp-25-8289-2025)
Diffusing protein binders to intrinsically disordered proteins
C Liu, K Wu, H Choi, HL Han, X Zhang, JL Watson, G Ahn, JZ Zhang, S Shijo, LL Good, CM Fischer, AK Bera, A Kang, E Brackenbrough, B Coventry, DR Hick, S Qamar, X Li, J Decarreau, SR Gerben, W Yang, I Goreshnik, D Vafeados, X Wang, M Lamb, A Murray, S Kenny, MS Bauer, AN Hoofnagle, P Zhu, TPJ Knowles, D Baker
– Nature
(2025)
644,
809
(DOI: 10.1038/s41586-025-09248-9)
Mechanistic diversity in the reactive adsorption of chlorine trifluoride on monohydrogenated silicon.
H Thake, SJ Jenkins
– Physical Chemistry, Chemical Physics - PCCP
(2025)
27,
15872
(DOI: 10.1039/d5cp01331c)
Kinetics of seeded protein aggregation: Theory and application.
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
– The Journal of chemical physics
(2025)
163,
045101
(DOI: 10.1063/5.0273677)
Development of Fully Interactive Hydrogen with Methane in UKESM1.0
MAJ Brown, NJ Warwick, NL Abraham, PT Griffiths, ST Rumbold, GA Folberth, FM O'Connor, AT Archibald
(2025)
(DOI: 10.5194/egusphere-2025-2676)
Small-diffusible aggregates, plaques, tangles, and dynamic equilibria: Untangling Alzheimer's disease.
E Fertan, G Meisl, D Klenerman
– Alzheimer S and Dementia
(2025)
21,
e70462
(DOI: 10.1002/alz.70462)
Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules.
A Stevenson, R Staats, AJ Dear, D Voderholzer, JE Dreier, G Meisl, R Guido, TPJ Knowles, C Galvagnion, AK Buell, M Vendruscolo, TCT Michaels
– Proceedings of the National Academy of Sciences of the United States of America
(2025)
122,
e2422427122
(DOI: 10.1073/pnas.2422427122)

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