Molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation
I Brakti, S Lenton, M Polimeni, H Ausserwöger, R Scrutton, A Henriksen, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, M Groenning, V Foderà
Commun Chem
(2026)
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
Sci Adv
(2026)
12
Dataset of aerosol, ozone, and meteorology observations at the surface coastal site of Henties Bay in Namibia
P Formenti, D Klopper, A Feron, M Cazaunau, S Chevaillier, K Desboeufs, C Di Biagio, C Baldo, C Gaimoz, V Michoud, C Mirande-Bret, S Triquet, F Hemeret, R Valorso, S Broccardo, A Namwoonde, M Hanghome, C Giorio, SJ Piketh
(2026)
Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson's disease brains.
E Fertan, JSH Danial, S Neame, JYL Lam, MW Cotton, M Burke, Z Xia, Y Wu, B Powney, Y Imaizumi, A Quaegebeur, G Meisl, J Staddon, D Klenerman
Cell reports methods
(2026)
The role of N-terminal acetylation on biomolecular condensation
C G Oliveira, MTS Silva, E Kava, T Agarwal, G Cereghetti, E F Vicente, TPJ Knowles, AJ Costa-Filho, LFS Mendes
Communications Chemistry
(2026)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
A Correlative SICM-OPM Platform for Surface and Volumetric Imaging in Live Cells.
W Hong, Z Zhang, A Li, T Sun, Y Wu, DM Vadukul, D Jones, B Li, F Liu, FA Aprile, Y Korchev, J Gorelik, D Klenerman, A Shevchuk
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
(2026)
Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer.
S Chakraborty, J Pramanik, G Alviter-Raymundo, CJ Ward, SK Shaji, Y Yamashita-Kanemaru, FAZ Ali, D Banik, Z Zhang, C Veiga-Villauriz, NZM Homer, J Simpson, S Laforest, S Tong, Q Zhao, J Roy, M Iqbal, AC Morris, MA Chapman, R Roychoudhuri, H Hussein, D Klenerman, K Saeb-Parsy, B Mahata
Signal Transduction and Targeted Therapy
(2026)
11
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates.
L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles
Advanced Science
(2026)
13
A swarm intelligence approach to density function reconstruction from moments using entropy optimization
P Biswas, SR Elliott
Proc Natl Acad Sci U S A
(2026)
123
Discovery of first-in-class YTHDC1 small molecule inhibitors for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, MJ Rawling, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, A Howarth, S Qamar, L Andraghetti, A Seeber, MG Kharas, S Cohen, M Kulander, T Knowles, S Arora
Cancer Research
(2026)
86
NPM1 Undergoes Salt-Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk
Y Zhen, Y Tan, Y Tang, T Sneideris, H Ausserwöger, J Wen, TPJ Knowles, S Perrett, G Wei, S Wu
Small (Weinheim an der Bergstrasse, Germany)
(2026)
Introducing Volatile Organic Compound Model Intercomparison Project (VOCMIP)
G Myhre, Ø Hodnebrog, S Krishnan, M Sand, M Sandstad, RB Skeie, L Clarisse, B Franco, DB Millet, KC Wells, A Archibald, HN Bryant, AT Chaudhri, DS Stevenson, D Hauglustaine, M Prather, JC Kaiser, DJL Olivie, M Schulz, O Wild, Y Wang, T Salameh, JE Williams, P Le Sager, F Paulot, K Tsigaridis, HE Plaas
Geoscientific Model Development
(2026)
19
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits.
R Ellingford, SS Harris, M Kehring, RM Rajani, FKW Lam, D Graykowski, D BÓ§ken, LA Welikovitch, A Khasnavis, R Laban, A Heslegrave, U Yaman, A Mate de Gerando, SA Bond, S Wray, DA Salih, D Dupret, RJ Dolan, D Klenerman, H Zetterberg, BT Hyman, MA Busche
Neuron
(2026)
Reversible peptide self-assembly enables sustained drug delivery with tuneable pharmacokinetics
TW Herling, J Wei, S Genapathy, C Rivera, M Persson, P Gennemark, D Workman, D Lundberg, E Bernard, H Bolt, MY Arteta, S Will, A Bak, D Hornigold, TPJ Knowles, ALG dos Santos
(2026)
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers
H Yuan, Z Yang, C Yuan, S Shankar, A Levin, T Lv, Z Wang, W Sun, J Sitton, P-A Cazade, Y Dan, Y Tang, L Adler-Abramovich, Y Cao, S Rencus-Lazar, D Thompson, D Kurouski, TPJ Knowles, LJW Shimon, G Wei, B Xue, R Yang, E Gazit
Nature Communications
(2026)
Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner.
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
Proceedings of the National Academy of Sciences
(2026)
123
Chemical softness as a predictor for reactivity at metal surfaces.
AL Gunton, SJ Jenkins
Phys Chem Chem Phys
(2026)
28
Evaluation of UKESM aerosol size and composition using ATom measurements indicates missing marine aerosol formation mechanisms
X-C He, NL Abraham, H Ding, MR Russo, DP Grosvenor, Y Ge, X Wang, AC Jones, P Campuzano-Jost, B Nault, A Kupc, D Blake, JL Jimenez, CJ Williamson, J Weber, AT Archibald, H Gordon
Atmospheric Chemistry and Physics (ACP)
(2026)
26
Chemical composition differences in gas- and particle-phase organic and DMS-derived oxidation products between a pristine marine environment and a wildfire-influenced marine air mass
F Sari Doré, R Wu, E Matthews, C Wu, T Bannan, H Coe, A Archibald, M Hallquist
(2026)
Organic matter in dust-dominated aerosols over Namibia influenced by biomass burning and marine emissions
A Zherebker, C Baldo, P Formenti, C Giorio
(2026)
Reversibility and β-sheet formation are decoupled in tau condensate aging
CM Fischer, IA Edu, T Šneideris, I Baronaite, Z Toprakcioglu, L-T Deck, D Qian, R Scrutton, L Dreyer, J Wen, DE Otzen, S Wu, S Perrett, TPJ Knowles
Proceedings of the National Academy of Sciences
(2026)
123
Determining the key sources of uncertainty in dimethyl sulfide and methanethiol oxidation under tropical, temperate, and polar marine conditions
LSD Jacob, BEH Harvey, C Giorio, AT Archibald
Atmospheric Chemistry and Physics (ACP)
(2026)
26
Constructing a single-objective oblique plane microscope (OPM) for fast, multi-colour, high-resolution volumetric fluorescence imaging
Z Zhang, W Hong, Y Wu, A Dey, A Shevchuk, D Klenerman
(2026)
Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome
MC Moncrieffe, P Suresh, J Boyle, Y Cui, B Nawalpuri, B Verstak, YP Zhang, Z Zhang, M Taylor, EH Egelman, N Gay, D Klenerman, C Bryant
Science Advances
(2026)
12