Rethinking neurodegeneration through a co-proteinopathy lens.
YP Zhang, S Kedia, D Klenerman
Trends Neurosci
(2025)
PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning.
SAH Jansen, LSA Dreyer, J van Basten, Y Yao, DE Otzen, TFA de Greef, TPJ Knowles, EW Meijer, NA Erkamp
ACS Nano
(2025)
19
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
Advanced Science
(2025)
Tuning the morphology of aerosolised cellulose nanocrystal particulates via controlled aggregation
D Warnes, W Xu, JH Lim, RM Parker, B Frka-Petesic, R Freshwater, C Honorato-Rios, Y Ogawa, C Giorio, S Vignolini
Carbohydrate Polymers
(2025)
373
Supplementary material to "Determining the key sources of uncertainty in dimethyl sulfide and methanethiol oxidation under tropical, temperate, and polar marine conditions"
LSD Jacob, BEH Harvey, C Giorio, AT Archibald
(2025)
Determining the key sources of uncertainty in dimethyl sulfide and methanethiol oxidation under tropical, temperate, and polar marine conditions
LSD Jacob, BEH Harvey, C Giorio, AT Archibald
(2025)
Tau catalyzes amyloid-β aggregation in a fold-dependent manner
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
(2025)
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
Beyond prion‐like spreading in neurodegenerative disease
G Meisl, JB Rowe, D Klenerman
Alzheimer's & Dementia
(2025)
21
Multi-state Protein Design with DynamicMPNN
A Abrudan, SP Ojeda, CK Joshi, M Greenig, F Engelberger, A Khmelinskaia, J Meiler, M Vendruscolo, TPJ Knowles
(2025)
Oxidative stress generated DNA damage by 6PPD and other tyre additives in A549 human lung epithelial cells
S Hyman, R Bilić, A Jensen, S Saladin, Y Tsybrii, O Nosko, D Topping, A Boies, C Giorio, M Roursgaard, P Møller
Scientific reports
(2025)
15
Formation and composition of organic aerosols from the uptake of glyoxal on natural mineral dust aerosols: a laboratory study
F Battaglia, P Formenti, C Giorio, M Cazaunau, E Pangui, A Bergé, A Gratien, DL Pereira, T Bertin, JF de Brito, MN Romanias, V Michoud, C Baldo, S Chevaillier, G Noyalet, P Decorse, B Picquet-Varrault, J-F Doussin
Atmospheric Chemistry and Physics
(2025)
25
Size of biomolecular condensates dictates fate in liquid–solid phase transitions through amorphous–amyloid competition
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
(2025)
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
Nature Biomedical Engineering
(2025)
Nano-org, a functional resource for single-molecule localisation microscopy data
S Shirgill, DJ Nieves, JA Pike, MA Ahmed, H Abbott, MHH Baragilly, K Savoye, JD Worboys, KS Hazime, E Bruggeman, A Garcia, DJ Williamson, P Rubin-Delanchy, R Peters, DM Davis, R Henriques, SF Lee, DM Owen
Nat Commun
(2025)
16
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates.
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, T Knowles, M Vendruscolo
Communications chemistry
(2025)
8
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
N Quittot, D Sivasankaran, D Boeken, Y Chen, JE Chun, A Wiedmer, V Derosla, MBMS Martins, FA Brooks, G Meisl, M Cotton, DG Arumuganainar, T Connors, A Melloni, M Frosch, D Oakley, L Makowski, M Wanunu, D Klenerman, BT Hyman
bioRxiv
(2025)
Optofluidic waveguides for the label-free study of silk protein aggregates
JR Heck, Z Toprakcioglu, TE Naegele, MH Frosz, TPJ Knowles, TG Euser
ACS Omega
(2025)
10
Highly oxygenated molecules (HOMs) and secondary organic aerosol (SOA) formation from the oxidation of α- and β-phellandrenes by NO3 radicals
S Harb, M Cirtog, S Alage, C Cantrell, M Cazaunau, V Michoud, E Pangui, A Bergé, C Giorio, F Battaglia, B Picquet-Varrault
Atmospheric Chemistry and Physics
(2025)
25
Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
(2025)
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
EE Prescott, J Wei, EF Garland, A Urbanek, F Capriglia, WH Molenkamp, DP Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, MO Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, JR Highly, TPJ Knowles, H Mortiboys, S De
(2025)
Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease
E Fertan, S Kedia, G Meisl, MW Cotton, A Quaegebeur, MG Spillantini, D Klenerman
(2025)
Transcript Identification Using Arrayed Hydrogels With TrapFISH (Adv. Mater. Technol. 18/2025)
DB Morse, Z Toprakcioglu, A Denduluri‐Marthi, JD Brenton, CJ Thomas, TPJ Knowles
Advanced Materials Technologies
(2025)
10