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Recent Publications from the Synthesis Research Interest Group

Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.
DJ Cole, M Janecek, JE Stokes, M Rossmann, JC Faver, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring, DJ Huggins, WL Jorgensen
– Chemical communications (Cambridge, England)
(2017)
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
– Bioorganic & medicinal chemistry
(2017)
25,
3471
Enantioselective Copper-Catalyzed Arylation-driven Semi-Pinacol Rearrangement of Allylic Alcohols with Diaryliodonium Salts
DH Lukamto, MJ Gaunt
– Journal of the American Chemical Society
(2017)
Enantioselective Copper-Catalyzed Arylation-Driven Semipinacol Rearrangement of Tertiary Allylic Alcohols with Diaryliodonium Salts.
DH Lukamto, MJ Gaunt
– Journal of the American Chemical Society
(2017)
139,
9160
Unveiling the role of boroxines in metal-free carbon–carbon homologations using diazo compounds and boronic acids
C Bomio, MA Kabeshov, AR Lit, S-H Lau, J Ehlert, C Battilocchio, SV Ley
– Chem. Sci.
(2017)
Cocrystals of spironolactone and griseofulvin based on an in silico screening method
T Grecu, R Prohens, JF McCabe, EJ Carrington, JS Wright, L Brammer, CA Hunter
– CrystEngComm
(2017)
19,
3592
Flow synthesis of cyclobutanones \textit{via} [2 + 2] cycloaddition of keteneiminium salts and ethylene gas
C Battilocchio, G Iannucci, S Wang, E Godineau, A Krieger, A De Mesmaeker, SV Ley
– Reaction Chemistry & Engineering
(2017)
2,
295
Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid beta (1-42)
TH Sum, TJ Sum, S Collins, WRJD Galloway, DG Twigg, F Hollfelder, DR Spring
– Org Biomol Chem
(2017)
15,
4554
Development and Application of Synthetic Affinity Ligands for the Purification of Ferritin-Based Influenza Antigens.
SI Jacob, B Khogeer, N Bampos, T Sheppard, R Schwartz, CR Lowe
– Bioconjugate Chemistry
(2017)
28,
1931
Controlled membrane translocation provides a mechanism for signal transduction and amplification
MJ Langton, F Keymeulen, M Ciaccia, NH Williams, CA Hunter
– Nature Chemistry
(2016)
9,
426
Enhanced Chelate Cooperativity in Polar Solvents.
S Henkel, MC Misuraca, Y Ding, M Guitet, CA Hunter
– Journal of the American Chemical Society
(2017)
139,
6675
H-Bond Acceptor Parameters for Anions.
SJ Pike, JJ Hutchinson, CA Hunter
– Journal of the American Chemical Society
(2017)
139,
6700
H-Bond Self-Assembly: Folding versus Duplex Formation
D Núñez-Villanueva, G Iadevaia, AE Stross, MA Jinks, JA Swain, CA Hunter
– Journal of the American Chemical Society
(2017)
139,
6654
Recognition-Controlled Membrane Translocation for Signal Transduction across Lipid Bilayers.
MJ Langton, NH Williams, CA Hunter
– Journal of the American Chemical Society
(2017)
139,
6461
Selective C<inf>70</inf> encapsulation by a robust octameric nanospheroid held together by 48 cooperative hydrogen bonds
G Markiewicz, A Jenczak, M Kołodziejski, JJ Holstein, JKM Sanders, AR Stefankiewicz
– Nature Communications
(2017)
8,
15109
Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.
JJ Field, PT Northcote, I Paterson, K-H Altmann, JF Díaz, JH Miller
– International journal of molecular sciences
(2017)
18,
971
Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium( ii ) catalyst
TTL Kwan, O Boutureira, EC Frye, SJ Walsh, MK Gupta, S Wallace, Y Wu, F Zhang, HF Sore, WRJD Galloway, JW Chin, M Welch, GJL Bernardes, DR Spring
– Chem. Sci.
(2017)
8,
3871
Reviewers in 2016
JKM Sanders
– Royal Society open science
(2017)
4,
170299
A possible extension to the RInChI as a means of providing machine readable process data
PM Jacob, T Lan, JM Goodman, AA Lapkin
– Journal of Cheminformatics
(2017)
9,
ARTN 23
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
SS Mohapatra, ZE Wilson, S Roy, SV Ley
– Tetrahedron
(2017)
73,
1812