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Recent Publications from the Synthesis Research Interest Group

A surface site interaction point methodology for macromolecules and huge molecular databases.
A Oliver, CA Hunter, R Prohens, JL Rosselló
– Journal of Computational Chemistry
(2017)
38,
419
(Z)-selective Takai olefination of salicylaldehydes
SM Geddis, CE Hagerman, WRJD Galloway, HF Sore, JM Goodman, DR Spring
– Beilstein J Org Chem
(2017)
13,
323
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase
W Xu, YH Lau, G Fischer, YS Tan, A Chattopadhyay, M de la Roche, M Hyvönen, C Verma, DR Spring, LS Itzhaki
– Journal of the American Chemical Society
(2017)
139,
2245
One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N -Tosylhydrazones: Access to 1,2,4-Triazines
L Crespin, L Biancalana, T Morack, DC Blakemore, SV Ley
– Organic Letters
(2017)
19,
1084
Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor
C Battilocchio, SH Lau, JM Hawkins, SV Ley
– Organic Syntheses
94,
34
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines
J-S Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley
– Angewandte Chemie International Edition (English)
(2017)
56,
1864
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines
J-S Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley
– Angewandte Chemie
(2017)
129,
1890
Stereocontrolled semi-syntheses of deguelin and tephrosin
DA Russell, JJ Freudenreich, JJ Ciardiello, HF Sore, DR Spring
– Org Biomol Chem
(2017)
15,
1593
Ion-Pair-Directed meta-Selective C–H Borylation of Aromatic Quaternary Ammonium Salts
MT Mihai, RJ Phipps
– Synlett
(2017)
Palladium-catalyzed enantioselective C-H activation of aliphatic amines using chiral anionic BINOL-phosphoric acid ligands
AP Smalley, JD Cuthbertson, MJ Gaunt
– Journal of the American Chemical Society
(2017)
139,
1412
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring
– Angewandte Chemie
(2016)
129,
539
An Expedient Total Synthesis of Chivosazole F: an Actin-Binding Antimitotic Macrolide from the Myxobacterium Sorangium Cellulosum
S Williams, J Jin, SBJ Kan, M Li, LJ Gibson, I Paterson
– Angew Chem Int Ed Engl
(2017)
56,
645
Solid form and solubility
CA Hunter, R Prohens
– CrystEngComm
(2017)
19,
23
Guest Binding and Catalysis in the Cavity of a Cubic Coordination Cage
MD Ward, CA Hunter, NH Williams
– Chemistry Letters
(2017)
46,
2
Transparency and openness in science
J Sanders, J Blundy, A Donaldson, S Brown, R Ivison, M Padgett, K Padian, K Rittinger, K Rowe, A Stace, E Viding, C Chambers, M Chaplain
– Royal Society Open Science
(2017)
4,
160979
Cobalt-catalysed C–H carbonylative cyclisation of aliphatic amides
P Williamson, A Galván, MJ Gaunt
– Chem. Sci.
(2017)
Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions
HJ Davis, RJ Phipps
– Chem. Sci.
(2017)
8,
864
Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells
C Trigili, I Barasoain, PA Sánchez-Murcia, K Bargsten, M Redondo-Horcajo, A Nogales, NM Gardner, A Meyer, GJ Naylor, E Gómez-Rubio, F Gago, MO Steinmetz, I Paterson, AE Prota, JF Díaz
– ACS Omega
(2016)
1,
1192
Complex peptides made simple
S Bartlett, DR Spring
– Nature Chemistry
(2016)
9,
9
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
SS Mohapatra, ZE Wilson, S Roy, SV Ley
– Tetrahedron
(2017)
73,
1812