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Professor Steve Ley FRS

Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)

Publications

Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide
C Battilocchio, JM Hawkins, SV Ley – Organic Letters (2014) 16, 1060
Fully automated sequence-specific synthesis of α-peptides using flow chemistry
KR Knudsen, M Ladlow, Z Bandpey, SV Ley – Journal of Flow Chemistry (2014) 4, 18
Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor
JA Newby, L Huck, DW Blaylock, PM Witt, SV Ley, DL Browne – Chemistry - A European Journal (2014) 20, 263
Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor.
JA Newby, L Huck, DW Blaylock, PM Witt, SV Ley, DL Browne – Chemistry (2014) 20, 263
Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids
DM Allwood, DC Blakemore, AD Brown, SV Ley – J Org Chem (2014) 79, 131210151213004
Sustainable Flow Oppenauer Oxidation of Secondary Benzylic Alcohols with a Heterogeneous Zirconia Catalyst
R Chorghade, C Battilocchio, JM Hawkins, SV Ley – Organic Letters (2013) 15, 5698
Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley – Chemistry & Biology (2013) 20, 1399
Flow chemistry syntheses of natural products
JC Pastre, DL Browne, SV Ley – Chemical Society reviews (2013) 42, 8849
The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow.
KA Roper, MB Berry, SV Ley – Beilstein journal of organic chemistry (2013) 9, 1781
Fragment-based hit identification: thinking in 3D.
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, T Chapman, M Drysdale, IH Gilbert, S Hoelder, A Jordan, SV Ley, A Merritt, D Miller, ME Swarbrick, PG Wyatt – Drug Discov Today (2013) 18, 1221
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Research Group

Research Interest Group

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk