In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Sustainable Flow Oppenauer Oxidation of Secondary Benzylic Alcohols with a Heterogeneous Zirconia Catalyst.
R Chorghade, C Battilocchio, JM Hawkins, SV Ley – Org Lett (2013
Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes
C Watts, F Richards, A Bender, P Bond, O Korb, O Kern, M Riddick, P Owen, R Myers, J Raff, F Gergely, D Jodrell, S Ley – Chemistry and Biology (2013
Scaling up of continuous flow processes with gases using a tube-in-tube reactor: Inline titrations and fanetizole synthesis with ammonia
JC Pastre, DL Browne, M O'Brien, SV Ley – Organic Process Research and Development (2013
Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen
PRD Murray, DL Browne, JC Pastre, C Butters, D Guthrie, SV Ley – Organic Process Research and Development (2013
The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow.
KA Roper, MB Berry, SV Ley – Beilstein J Org Chem (2013
Flow synthesis and biological studies of an analgesic adamantane derivative that inhibits P2X7-evoked glutamate release
C Battilocchio, L Guetzoyan, C Cervetto, L Di Cesare Mannelli, D Frattaroli, IR Baxendale, G Maura, A Rossi, L Sautebin, M Biava, C Ghelardini, M Marcoli, SV Ley – ACS Medicinal Chemistry Letters (2013
Fragment-based hit identification: thinking in 3D.
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, T Chapman, M Drysdale, IH Gilbert, S Hoelder, A Jordan, SV Ley, A Merritt, D Miller, ME Swarbrick, PG Wyatt – Drug Discov Today (2013
A continuous flow solution to achieving efficient aerobic anti-Markovnikov Wacker oxidation
SL Bourne, SV Ley – Advanced Synthesis & Catalysis (2013
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research
IR Baxendale, S Cheung, MO Kitching, SV Ley, JW Shearman – Bioorganic and Medicinal Chemistry (2013
Studies of a diastereoselective electrophilic fluorination reaction employing a cryo-flow reactor
K Nakayama, DL Browne, IR Baxendale, SV Ley – Synlett (2013