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Professor Steve Ley CBE FRS FMedSci

Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)

Publications

Taming hazardous chemistry by continuous flow technology.
M Movsisyan, EIP Delbeke, JKET Berton, C Battilocchio, SV Ley, CV Stevens
– Chemical Society reviews
(2016)
Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation.
J-S Poh, C García-Ruiz, A Zúñiga, F Meroni, DC Blakemore, DL Browne, SV Ley
– Org Biomol Chem
(2016)
14,
5983
Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.
CL Sutherell, C Tallant, OP Monteiro, C Yapp, JE Fuchs, O Fedorov, P Siejka, S Müller, S Knapp, JD Brenton, PE Brennan, SV Ley
– J Med Chem
(2016)
59,
5095
Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
T Ouchi, RJ Mutton, V Rojas, DE Fitzpatrick, DG Cork, C Battilocchio, SV Ley
– ACS Sustainable Chemistry and Engineering
(2016)
4,
1912
Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
T Ouchi, RJ Mutton, V Rojas, DE Fitzpatrick, DG Cork, C Battilocchio, SV Ley
– ACS Sustainable Chemistry & Engineering
(2016)
4,
1912
Iterative reactions of transient boronic acids enable sequential C-C bond formation.
C Battilocchio, F Feist, A Hafner, M Simon, DN Tran, DM Allwood, DC Blakemore, SV Ley
– Nature Chemistry
(2016)
8,
360
Enabling Technologies for the Future of Chemical Synthesis.
DE Fitzpatrick, C Battilocchio, SV Ley
– ACS central science
(2016)
2,
131
Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry.
D Lücke, T Dalton, SV Ley, ZE Wilson
– Chemistry
(2016)
22,
4206
A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
J-S Poh, DL Browne, SV Ley
– React. Chem. Eng.
(2016)
1,
101
A Novel Internet-Based Reaction Monitoring, Control and Autonomous Self-Optimization Platform for Chemical Synthesis
DE Fitzpatrick, C Battilocchio, SV Ley
– Organic Process Research and Development
(2016)
20,
386
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk