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Professor Steve Ley CBE FRS FMedSci

Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)

Publications

One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N -Tosylhydrazones: Access to 1,2,4-Triazines
L Crespin, L Biancalana, T Morack, DC Blakemore, SV Ley
– Organic Letters
(2017)
19,
1084
Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor
C Battilocchio, SH Lau, JM Hawkins, SV Ley
– Organic Syntheses
94,
34
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines
J-S Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley
– Angewandte Chemie
(2017)
129,
1890
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines
J-S Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley
– Angewandte Chemie International Edition (English)
(2017)
56,
1864
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
SS Mohapatra, ZE Wilson, S Roy, SV Ley
– Tetrahedron
(2017)
73,
1812
Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform
DE Fitzpatrick, SV Ley
– React. Chem. Eng.
(2016)
1,
629
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp 2 )-C(sp 3 ) Cross-Couplings in Flow
F Lima, MA Kabeshov, DN Tran, C Battilocchio, J Sedelmeier, G Sedelmeier, B Schenkel, SV Ley
– Angewandte Chemie
(2016)
128,
14291
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp(2) )-C(sp(3) ) Cross-Couplings in Flow.
F Lima, MA Kabeshov, DN Tran, C Battilocchio, J Sedelmeier, G Sedelmeier, B Schenkel, SV Ley
– Angew Chem Int Ed Engl
(2016)
55,
14085
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
S Picaud, K Leonards, J-P Lambert, O Dovey, C Wells, O Fedorov, O Monteiro, T Fujisawa, C-Y Wang, H Lingard, C Tallant, N Nikbin, L Guetzoyan, R Ingham, SV Ley, P Brennan, S Muller, A Samsonova, A-C Gingras, J Schwaller, G Vassiliou, S Knapp, P Filippakopoulos
– Sci Adv
(2016)
2,
e1600760
Continuous Processing and Efficient in Situ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy
B Ahmed-Omer, E Sliwinski, JP Cerroti, SV Ley
– Organic Process Research and Development
(2016)
20,
1603
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk