In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Flow chemistry syntheses of natural products.
JC Pastre, DL Browne, SV Ley - Chem Soc Rev (
2013)
(DOI:
10.1039/c3cs60246j)
Flow synthesis and biological studies of an analgesic adamantane derivative that inhibits P2X7-evoked glutamate release
C Battilocchio, L Guetzoyan, C Cervetto, L Di Cesare Mannelli, D Frattaroli, IR Baxendale, G Maura, A Rossi, L Sautebin, M Biava, C Ghelardini, M Marcoli, SV Ley - ACS Medicinal Chemistry Letters (
2013)
4, 704
(DOI:
10.1021/ml400079h)
Fragment-based hit identification: thinking in 3D.
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, T Chapman, M Drysdale, IH Gilbert, S Hoelder, A Jordan, SV Ley, A Merritt, D Miller, ME Swarbrick, PG Wyatt - Drug Discov Today (
2013)
(DOI:
10.1016/j.drudis.2013.07.011)
A continuous flow solution to achieving efficient aerobic anti-Markovnikov Wacker oxidation
SL Bourne, SV Ley - Advanced Synthesis & Catalysis (
2013)
355, 1905
(DOI:
10.1002/adsc.201300278)
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research
IR Baxendale, S Cheung, MO Kitching, SV Ley, JW Shearman - Bioorganic and Medicinal Chemistry (
2013)
21, 4378
(DOI:
10.1016/j.bmc.2013.04.075)
Studies of a diastereoselective electrophilic fluorination reaction employing a cryo-flow reactor
K Nakayama, DL Browne, IR Baxendale, SV Ley - Synlett (
2013)
24, 1298
(DOI:
10.1055/s-0033-1338455)
A Machine-assisted flow synthesis of SR48692: A probe for the investigation of neurotensin receptor-1
C Battilocchio, BJ Deadman, N Nikbin, MO Kitching, IR Baxendale, SV Ley - Chemistry (
2013)
19, 7917
(DOI:
10.1002/chem.201300696)
Continuous Cold without Cryogenic Consumables: Development of a Convenient Laboratory Tool for Low-Temperature Flow Processes
DL Browne, BH Harji, SV Ley - Chemical Engineering and Technology (
2013)
36, n/a
(DOI:
10.1002/ceat.201200581)
Camera-enabled techniques for organic synthesis
SV Ley, RJ Ingham, M O'Brien, DL Browne - Beilstein J Org Chem (
2013)
9, 1051
(DOI:
10.3762/bjoc.9.118)
A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia
C Battilocchio, JM Hawkins, SV Ley - Organic Letters (
2013)
15, 2278
(DOI:
10.1021/ol400856g)
