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Professor Steve Ley FRS

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In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)


Back pressure regulation of slurry-forming reactions in continuous flow
BJ Deadman, DL Browne, IR Baxendale, SV Ley – Chemical Engineering and Technology (2015) 38, 259
Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds
DN Tran, C Battilocchio, S-B Lou, JM Hawkins, SV Ley – Chem. Sci. (2015) 6, 1120
Flow Chemistry: Intelligent Processing of Gas–Liquid Transformations Using a Tube-in-Tube Reactor
M Brzozowski, M O'Brien, SV Ley, A Polyzos – Accounts of Chemical Research (2015) 48, 349
Cyclopropanation using flow-generated diazo compounds.
NM Roda, DN Tran, C Battilocchio, R Labes, RJ Ingham, JM Hawkins, SV Ley – Org Biomol Chem (2015) 13, 2550
Organic Synthesis: March of the Machines.
SV Ley, DE Fitzpatrick, RJ Ingham, RM Myers – Angew Chem Int Ed Engl (2015) 54, n/a
Back Pressure Regulation of Slurry-Forming Reactions in Continuous Flow
BJ Deadman, DL Browne, IR Baxendale, SV Ley – Chemical Engineering and Technology (2015) 38, 259
Total syntheses of linear polythiazole/oxazole plantazolicin a and its biosynthetic precursor plantazolicin b.
ZE Wilson, S Fenner, SV Ley – Angew Chem Int Ed Engl (2015) 54, 1284
Process intensification for the continuous flow hydrogenation of ethyl nicotinate
T Ouchi, C Battilocchio, JM Hawkins, SV Ley – Organic Process Research and Development (2014) 18, 1560
A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences
RJ Ingham, C Battilocchio, DE Fitzpatrick, E Sliwinski, JM Hawkins, SV Ley – Angew Chem Int Ed Engl (2015) 54, 144
The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions
S Glöckner, DN Tran, RJ Ingham, S Fenner, ZE Wilson, C Battilocchio, SV Ley – Org Biomol Chem (2015) 13, 207
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01223 336398

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