In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration.
PB Cranwell, M O'Brien, DL Browne, P Koos, A Polyzos, M Peña-López, SV Ley - Org Biomol Chem (
2012)
(DOI:
10.1039/c2ob25407g)
Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.
TM Beale, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers - Bioorganic and Medicinal Chemistry (
2012)
20, 1749
(DOI:
10.1016/j.bmc.2012.01.010)
A-Ring Dihalogenation Increases the Cellular Activity of Combretastatin-Templated Tetrazoles
TM Beale, DM Allwood, A Bender, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers, JW Shearman, J Temple, J Unger, CA Watts, J Xian - ACS Medicinal Chemistry Letters (
2012)
3, 177
(DOI:
10.1021/ml200149g)
The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact
TP Petersen, A Polyzos, M O'Brien, T Ulven, IR Baxendale, SV Ley - ChemSusChem (
2012)
5, 274
(DOI:
10.1002/cssc.201100339)
A total synthesis of millingtonine A.
J Wegner, SV Ley, A Kirschning, AL Hansen, JM Garcia, IR Baxendale - Organic Letters (
2012)
14, 696
(DOI:
10.1021/ol203158p)
Scale-up of flow-assisted synthesis of C 2-symmetric chiral PyBox ligands
C Battilocchio, M Baumann, IR Baxendale, M Biava, MO Kitching, SV Ley, RE Martin, SA Ohnmacht, NDC Tappin - Synthesis (
2012)
44, 635
(DOI:
10.1055/s-0031-1289676)
Scale-Up of Flow-Assisted Synthesis of C 2-Symmetric Chiral PyBox Ligands
C Battilocchio, M Baumann, IR Baxendale, M Biava, MO Kitching, SV Ley, RE Martin, SA Ohnmacht, NDC Tappin - Synthesis (2012)
Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1
TM Beale, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers - Bioorganic and Medicinal Chemistry (2012) 20, 1749
Piecing together the puzzle: understanding a mild, metal free reduction method for the large scale synthesis of hydrazines
DL Browne, IR Baxendale, SV Ley - Tetrahedron (
2011)
67, 10296
(DOI:
10.1016/j.tet.2011.09.146)
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.
KA Roper, H Lange, A Polyzos, MB Berry, IR Baxendale, SV Ley - Beilstein J Org Chem (
2011)
7, 1648
(DOI:
10.3762/bjoc.7.194)
