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Professor Steve Ley FRS

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In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)


Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439.
SH Lau, A Galván, RR Merchant, C Battilocchio, JA Souto, MB Berry, SV Ley – Organic letters (2015)
A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds.
JS Poh, DN Tran, C Battilocchio, JM Hawkins, SV Ley – Angew Chem Int Ed Engl (2015) 54, n/a
A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1
LC Alves, AL Desiderá, KT de Oliveira, S Newton, SV Ley, TJ Brocksom – Org Biomol Chem (2015)
Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation
A Hafner, SV Ley – Synlett (2015)
Development of a web-based platform for studying lithiation reactions in silico.
MA Kabeshov, É Sliwiński, DE Fitzpatrick, B Musio, JA Newby, WD Blaylock, SV Ley – Chemical communications (Cambridge, England) (2015) 51, 7172
Organic synthesis: March of the machines
SV Ley, DE Fitzpatrick, RJ Ingham, RM Myers – Angewandte Chemie - International Edition (2015) 54, 3449
Development of a flow method for the hydroboration/oxidation of olefins.
JA Souto, RA Stockman, SV Ley – Org Biomol Chem (2015) 13, 3871
Back pressure regulation of slurry-forming reactions in continuous flow
BJ Deadman, DL Browne, IR Baxendale, SV Ley – Chemical Engineering and Technology (2015) 38, 259
Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds
DN Tran, C Battilocchio, S-B Lou, JM Hawkins, SV Ley – Chem. Sci. (2015) 6, 1120
Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor.
M Brzozowski, M O'Brien, SV Ley, A Polyzos – Accounts of Chemical Research (2015) 48, 349
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Research Group

Research Interest Groups

Telephone number

01223 336398

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