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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Continuous Flow Techniques in the Total Synthesis of Jaspine B: Part II.
M Gurský, D Trnovcová, P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza
– J Org Chem
(2025)
acs.joc.5c01799
Straightforward, Scalable, Solution-Phase Synthesis of Peptide Bonds in Flow.
ZE Wilson, E Lopez, NJ Flodén, C Watkins, G Bianchini, SV Ley
– Journal of flow chemistry
(2025)
15,
67
Carbonylative transformations with Pd catalysts supported on bio-degradable urea-based polymer - Part A
M Markovič, P Lopatka, P Koóš, T Soták, A Ház, T Gracza, SV Ley, M Králik
– Catalysis Today
(2024)
441,
114903
Palladium catalysts supported on biodegradable urea-based polymers in synthesis with CO - Part B
M Markovič, P Lopatka, P Koóš, T Soták, A Ház, T Gracza, SV Ley, M Králik
– Catalysis Today
(2024)
440,
114831
Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue
SC Schäfer, AM Voll, A Bracher, SV Ley, F Hausch
– Bioorganic and Medicinal Chemistry Letters
(2024)
104,
129728
Continuous flow synthesis enabling reaction discovery.
AI Alfano, J García-Lacuna, OM Griffiths, SV Ley, M Baumann
– Chemical Science
(2024)
15,
4618
Nitro-sulfinate Reductive Coupling to Access (Hetero)aryl Sulfonamides.
SE Gatarz, OM Griffiths, HA Esteves, W Jiao, P Morse, EL Fisher, DC Blakemore, SV Ley
– The Journal of Organic Chemistry
(2024)
89,
1898
Photoredox-Catalyzed Preparation of Sulfones Using Bis-Piperidine Sulfur Dioxide - An Underutilized Reagent for SO2 Transfer
OM Griffiths, HA Esteves, DC Emmet, SV Ley
– Chemistry
(2024)
30,
e202303976
Automated multistep synthesis of 2-pyrazolines in continuous flow
SV Ley, R Labes, JC Pastre, RJ Ingham, C Battilocchio, HM Marçon, MCFCB Damião, DN Tran
– Reaction Chemistry and Engineering
(2023)
9,
558
The Evolution of Flow Chemistry: An Opinion on Factors Driving Innovation.
SL Bourne, F Amann, SV Ley
– Chimia (Aarau)
(2023)
77,
288
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk