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Professor Steve Ley FRS

Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)

Publications

Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride
C Schotten, C Schotten, D Plaza, S Manzini, SP Nolan, SV Ley, DL Browne, A Lapkin – ACS Sustainable Chemistry & Engineering (2015) 3, 1453
Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation
A Hafner, SV Ley – Synlett (2015) 26, 1470
Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439.
SH Lau, A Galván, RR Merchant, C Battilocchio, JA Souto, MB Berry, SV Ley – Organic Letters (2015) 17, 3218
A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds
JS Poh, DN Tran, C Battilocchio, JM Hawkins, SV Ley – Angewandte Chemie - International Edition (2015) 54, 7920
A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds.
JS Poh, DN Tran, C Battilocchio, JM Hawkins, SV Ley – Angew Chem Int Ed Engl (2015) 54, 7920
A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1
LDEC Alves, AL Desiderá, KT de Oliveira, S Newton, SV Ley, TJ Brocksom – Org Biomol Chem (2015) 13, 7633
Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation
A Hafner, SV Ley – Synlett (2015) 26, 1470
Development of a web-based platform for studying lithiation reactions in silico.
MA Kabeshov, É Sliwiński, DE Fitzpatrick, B Musio, JA Newby, WD Blaylock, SV Ley – Chemical communications (Cambridge, England) (2015) 51, 7172
Organic synthesis: March of the machines
SV Ley, DE Fitzpatrick, RJ Ingham, RM Myers – Angewandte Chemie - International Edition (2015) 54, 3449
Development of a flow method for the hydroboration/oxidation of olefins.
JA Souto, RA Stockman, SV Ley – Org Biomol Chem (2015) 13, 3871
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk