In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.
For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)
Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide.
C Battilocchio, JM Hawkins, SV Ley – Organic Letters (2014
Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids
DM Allwood, DC Blakemore, AD Brown, SV Ley – J Org Chem (2014
Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor.
JA Newby, L Huck, DW Blaylock, PM Witt, SV Ley, DL Browne – Chemistry (2014
Fragment-based hit identification: thinking in 3D.
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, T Chapman, M Drysdale, IH Gilbert, S Hoelder, A Jordan, SV Ley, A Merritt, D Miller, ME Swarbrick, PG Wyatt – Drug Discov Today (2013
Flow chemistry syntheses of natural products
JC Pastre, DL Browne, SV Ley – Chemical Society reviews (2013
Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley – Chemistry & Biology (2013
Sustainable Flow Oppenauer Oxidation of Secondary Benzylic Alcohols with a Heterogeneous Zirconia Catalyst
R Chorghade, C Battilocchio, JM Hawkins, SV Ley – Organic Letters (2013
Scaling up of continuous flow processes with gases using a tube-in-tube reactor: Inline titrations and fanetizole synthesis with ammonia
JC Pastre, DL Browne, M O'Brien, SV Ley – Organic Process Research and Development (2013
Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen
PRD Murray, DL Browne, JC Pastre, C Butters, D Guthrie, SV Ley – Organic Process Research and Development (2013
The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow.
KA Roper, MB Berry, SV Ley – Beilstein journal of organic chemistry (2013