skip to content
 

Professor Steve Ley CBE FRS FMedSci

Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)

Publications

Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp 2 )-C(sp 3 ) Cross-Couplings in Flow
F Lima, MA Kabeshov, DN Tran, C Battilocchio, J Sedelmeier, G Sedelmeier, B Schenkel, SV Ley
– Angewandte Chemie
(2016)
128,
14291
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp(2) )-C(sp(3) ) Cross-Couplings in Flow.
F Lima, MA Kabeshov, DN Tran, C Battilocchio, J Sedelmeier, G Sedelmeier, B Schenkel, SV Ley
– Angew Chem Int Ed Engl
(2016)
55,
14085
Combination of Enabling Technologies to Improve and Describe the Stereoselectivity of Wolff-Staudinger Cascade Reaction
B Musio, F Mariani, EP Śliwiński, MA Kabeshov, H Odajima, SV Ley
– Synthesis (Germany)
(2016)
48,
3515
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
S Picaud, K Leonards, J-P Lambert, O Dovey, C Wells, O Fedorov, O Monteiro, T Fujisawa, C-Y Wang, H Lingard, C Tallant, N Nikbin, L Guetzoyan, R Ingham, SV Ley, P Brennan, S Muller, A Samsonova, A-C Gingras, J Schwaller, G Vassiliou, S Knapp, P Filippakopoulos
– Sci Adv
(2016)
2,
e1600760
Continuous Processing and Efficient in Situ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy
B Ahmed-Omer, E Sliwinski, JP Cerroti, SV Ley
– Organic Process Research and Development
(2016)
20,
1603
The Total Synthesis of the Bioactive Natural Product PlantazolicinA and Its Biosynthetic Precursor PlantazolicinB
S Fenner, ZE Wilson, SV Ley
– Chemistry
(2016)
22,
15902
Flow Chemistry in Europe
V Hessel, SV Ley
– Journal of Flow Chemistry
(2016)
6,
135
Taming hazardous chemistry by continuous flow technology
M Movsisyan, EIP Delbeke, JKET Berton, C Battilocchio, SV Ley, CV Stevens
– Chemical Society reviews
(2016)
45,
4892
Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation.
J-S Poh, C García-Ruiz, A Zúñiga, F Meroni, DC Blakemore, DL Browne, SV Ley
– Org Biomol Chem
(2016)
14,
5983
Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.
CL Sutherell, C Tallant, OP Monteiro, C Yapp, JE Fuchs, O Fedorov, P Siejka, S Müller, S Knapp, JD Brenton, PE Brennan, SV Ley
– J Med Chem
(2016)
59,
5095
  • <
  • 2 of 89
  • >

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk